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Displaying results 871 - 880 of 10000 in total
  1. Target

    Transcription factor RelB

    go.drugbank.com/bio_entities/BE0013795
    TargetHumans

    In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which … The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity

    Synonyms: I-Rel
  2. Drug

    Dapagliflozin

    go.drugbank.com/drugs/DB06292
    ApprovedInvestigational

    [A261601] Dapagliflozin was originally approved by the FDA on Jan 08, 2014, to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise. … [A261596] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria

    Mixtures: XIGLIF-M, PLEMTUM-MCategories: Drugs Used in Diabetes, P-glycoprotein substrates
  3. Drug

    Caffeine

    go.drugbank.com/drugs/DB00201
    ApprovedInvestigational

    [A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans. … [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.

    Synonyms: 1-methyltheobromine, 7-methyltheophyllineInternational brands: No-Doz, Wake-Up
  4. Drug

    Arbutamine

    go.drugbank.com/drugs/DB01102
    Approved

    Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in … diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .

    Categories: Compounds used in a research, industrial, or household setting, Adrenergic beta-1 Receptor Agonists
  5. Drug

    Lisinopril

    go.drugbank.com/drugs/DB00722
    ApprovedInvestigational

    Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction. … [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.

    Mixtures: Nu-lisinopril/hctz, Nu-lisinopril/hctzCategories: Compounds used in a research, industrial, or household setting, Agents Acting on the Renin-Angiotensin System
  6. Drug

    Linezolid

    go.drugbank.com/drugs/DB00601
    ApprovedInvestigational

    Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. … [L32965] Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically, it binds to the 23S ribosomal RNA of the 50S subunit[A11227,A199050

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
  7. Drug

    Ceftriaxone

    go.drugbank.com/drugs/DB01212
    ApprovedInvestigational

    Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S.aureus. … [A215582] It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges[A215582], eyes[A215647], and inner ear[A215627].

    Mixtures: CEF-3 INJECTION IM (1G), CEF-3 INJECTION IM (1G)Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-Ring
  8. Indication

    Haemangioma

    go.drugbank.com/conditions/DBCOND0017266
    Drugs: Propranolol · Triamcinolone
    Synonyms: Hemangioma, no ICD-O subtype, Hemangioma, no International Classification of Diseases for Oncology subtype
  9. Drug

    Simvastatin

    go.drugbank.com/drugs/DB00641
    ApprovedInvestigational

    were found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while simvastatin has been found to have an average decrease in LDL-C of ~35%. … It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the

    Mixtures: TIAZOMET S®, TIAZOMET S®Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  10. Drug

    Vitamin D

    go.drugbank.com/drugs/DB11094
    ApprovedInvestigationalNutraceuticalVet approved

    Since vitamin D can be endogenously synthesized in adequate amounts by most mammals exposed to sufficient quantities of sunlight, vitamin D functions like a hormone on vitamin D receptors to regulate calcium … Vitamin D3 and D2 require hydroxylation in order to become biologically active in the human body.

    Synonyms: Vitamin D NOS, D VitaminMixtures: Super Daily No 2, Multi Plex I - Tab