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Displaying results 881 - 890 of 3387 in total
  1. Target

    C-C chemokine receptor type 3

    go.drugbank.com/bio_entities/BE0013339
    TargetHumans

    May also act as a possible functional receptor for NARS1 (PubMed:30171954) … G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed:28994588).

    Polypeptides: C-C chemokine receptor type 3Synonyms: Eosinophil eotaxin receptor
  2. Target

    C-C chemokine receptor type 8

    go.drugbank.com/bio_entities/BE0013343
    TargetHumans

    G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis.

    Polypeptides: C-C chemokine receptor type 8Synonyms: Chemokine receptor-like 1, CC chemokine receptor CHEMR1
  3. Target

    Oncostatin-M-specific receptor subunit beta

    go.drugbank.com/bio_entities/BE0018846
    TargetHumans

    Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer … In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15627637)

    Polypeptides: Oncostatin-M-specific receptor subunit betaSynonyms: IL-31 receptor subunit beta, Interleukin-31 receptor subunit beta
  4. Target

    Taste receptor type 2 member 4

    go.drugbank.com/bio_entities/BE0020472
    TargetHumans

    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

    Polypeptides: Taste receptor type 2 member 4Function: bitter taste receptor activity
  5. Target

    Short transient receptor potential channel 6

    go.drugbank.com/bio_entities/BE0020965
    TargetHumans

    Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol

    Polypeptides: Short transient receptor potential channel 6Synonyms: Transient receptor protein 6
  6. Target

    Neuropeptide Y receptor type 4-2

    go.drugbank.com/bio_entities/BE0024014
    TargetHumans

    G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP.

    Polypeptides: Neuropeptide Y receptor type 4-2Function: pancreatic polypeptide receptor activity
  7. Target

    T cell receptor gamma variable 9

    go.drugbank.com/bio_entities/BE0025222
    TargetHumans

    V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor gamma variable 9
  8. Drug

    Edoxaban

    go.drugbank.com/drugs/DB09075
    ApprovedInvestigational

    is indicated to reduce the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF) and for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE

    Categories: P-glycoprotein substrates
  9. Drug

    AP5346

    go.drugbank.com/drugs/DB04992
    Investigational

    AP5346 is designed to target a diaminocyclohexane platinum (Pt) moiety to tumors through pH-sensitive linkage to a 25 kDa hydroxypropylmethacrylamide polymer.

  10. Target

    Vascular endothelial growth factor receptor 3

    go.drugbank.com/bio_entities/BE0000023
    TargetHumans

    The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. … Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular

    Polypeptides: Vascular endothelial growth factor receptor 3Synonyms: Tyrosine-protein kinase receptor FLT4