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Displaying results 881 - 890 of 10000 in total
  1. Target

    A-type voltage-gated potassium channel KCND2

    go.drugbank.com/bio_entities/BE0003603
    TargetHumans

    In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. … Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity).

    Polypeptides: A-type voltage-gated potassium channel KCND2Function: A-type (transient outward) potassium channel activity
  2. Target

    A-type voltage-gated potassium channel KCND3

    go.drugbank.com/bio_entities/BE0003604
    TargetHumans

    In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). … Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed

    Polypeptides: A-type voltage-gated potassium channel KCND3Function: A-type (transient outward) potassium channel activity
  3. Target

    A-type voltage-gated potassium channel KCND1

    go.drugbank.com/bio_entities/BE0004726
    TargetHumans

    Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative … Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons.

    Polypeptides: A-type voltage-gated potassium channel KCND1Function: A-type (transient outward) potassium channel activity
  4. Target

    cAMP-dependent protein kinase (Protein kinase A)

    go.drugbank.com/bio_entities/BE0010127
    TargetHumans

    Phosphorylates a large number of substrates in the cytoplasm and the nucleus … Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131)

  5. Drug

    Hydrogen peroxide

    go.drugbank.com/drugs/DB11091
    ApprovedInvestigationalVet approved

    Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. … It is used in industrial and cosmetic applications as a bleaching agent.

    Mixtures: Prevention Wound and Burn, Defense AG DisinfectantCategories: Compounds used in a research, industrial, or household setting
  6. Target

    V-type proton ATPase catalytic subunit A

    go.drugbank.com/bio_entities/BE0003569
    TargetHumans

    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates … May play a role in neurite development and synaptic connectivity (PubMed:29668857)

    Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit A
  7. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Plays a role in the vascular response to injury (By similarity)

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1
  8. Target

    Inositol polyphosphate-4-phosphatase type I A

    go.drugbank.com/bio_entities/BE0018619
    EnzymeHumans

    Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). ...

    Polypeptides: Inositol polyphosphate-4-phosphatase type I A
  9. Drug

    Carmustine

    go.drugbank.com/drugs/DB00262
    ApprovedInvestigational

    A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: N,N'-Bis(2-chloroethyl)-N-nitrosourea
  10. Target

    Vascular endothelial growth factor A, long form

    go.drugbank.com/bio_entities/BE0000163
    TargetHumans

    Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)

    Polypeptides: Vascular endothelial growth factor A, long form