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Free fatty acid receptor 4
go.drugbank.com/bio_entities/BE0003399TargetHumansConsequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (By similarity). … Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (By similarity). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (By similarity).
Polypeptides: Free fatty acid receptor 4Synonyms: Omega-3 fatty acid receptor 1Fatty acid-binding protein, intestinal
go.drugbank.com/bio_entities/BE0003591CarrierTargetHumansFABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. … Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids.
Polypeptides: Fatty acid-binding protein, intestinalSynonyms: Fatty acid-binding protein 2, Intestinal-type fatty acid-binding proteinIleal sodium/bile acid cotransporter
go.drugbank.com/bio_entities/BE0003643TransporterTargetHumansWorks collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling … Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990).
Polypeptides: Ileal sodium/bile acid cotransporterSynonyms: Ileal Na(+)/bile acid cotransporter, Apical sodium-dependent bile acid transporterAlpha-1-acid glycoprotein 2
go.drugbank.com/bio_entities/BE0003663TargetHumansAlso binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction
Polypeptides: Alpha-1-acid glycoprotein 2Free fatty acid receptor 2
go.drugbank.com/bio_entities/BE0010131TargetHumansIn addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence … In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers.
Polypeptides: Free fatty acid receptor 2Cellular retinoic acid-binding protein 1
go.drugbank.com/bio_entities/BE0000508CarrierTransporterTargetHumansCytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors
Polypeptides: Cellular retinoic acid-binding protein 1Synonyms: Cellular retinoic acid-binding protein IProton-coupled amino acid transporter 1
go.drugbank.com/bio_entities/BE0000536TargetTransporterHumansElectrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA (PubMed:12527723, PubMed: … May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis (By similarity).
Polypeptides: Proton-coupled amino acid transporter 1Synonyms: Proton/amino acid transporter 1Retinoic acid receptor responder protein 1
go.drugbank.com/bio_entities/BE0000653TargetHumansInhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle
Polypeptides: Retinoic acid receptor responder protein 1Cellular retinoic acid-binding protein 2
go.drugbank.com/bio_entities/BE0000782CarrierTransporterHumansTransports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors
Polypeptides: Cellular retinoic acid-binding protein 2Synonyms: Cellular retinoic acid-binding protein IINicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
go.drugbank.com/bio_entities/BE0001832TargetHumansCan also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. … Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury (PubMed:16118205, PubMed:17402747).
Polypeptides: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3