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Abiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalAbiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis … [L54773,L54768] As abiraterone has poor oral bioavailability and is susceptible to hydrolysis by esterases, abiraterone acetate was developed as an orally bioavailable prodrug with enhanced stability
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-ol, 17-(3-Pyridyl)androsta-5,16-dien-3beta-olHydrogen peroxide
go.drugbank.com/drugs/DB11091ApprovedInvestigationalVet approvedHydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. … It is used in industrial and cosmetic applications as a bleaching agent.
Mixtures: Defense AG Disinfectant, Defense AG DisinfectantCategories: Compounds used in a research, industrial, or household settingVecuronium
go.drugbank.com/drugs/DB01339ApprovedInvestigationalA non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. … Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or
Categories: P-glycoprotein substratesProducts: BROMURO DE VECURONIO 4 MG/VIAL POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE, BROCURIX 10 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLEPegfilgrastim
go.drugbank.com/drugs/DB00019ApprovedInvestigationalPegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. … [A29,A187607] Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim; however, pegfilgrastim has a comparable pharmacological
Synonyms: 吉新芬, PEG-G-CSFCategories: Compounds used in a research, industrial, or household settingConditions where a reduction of gastric acid secretion is required
go.drugbank.com/conditions/DBCOND0117234Drugs: PantoprazoleSynonyms: Conditions where a reduction of gastric acid secretion is requiredPexastimogene devacirepvec
go.drugbank.com/drugs/DB15069InvestigationalPexastimogene devacirepvec is under investigation in clinical trial NCT00429312 (A Study of Recombinant Vaccinia Virus to Treat Malignant Melanoma).
Synonyms: Pexa-VecPleckstrin homology domain-containing family A member 4
go.drugbank.com/bio_entities/BE0001278TargetHumansBinds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides
Polypeptides: Pleckstrin homology domain-containing family A member 4Synonyms: PH domain-containing family A member 4Pleckstrin homology domain-containing family A member 1
go.drugbank.com/bio_entities/BE0003262TargetHumansBinds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane
Polypeptides: Pleckstrin homology domain-containing family A member 1Synonyms: PH domain-containing family A member 1Potassium voltage-gated channel subfamily A member 4
go.drugbank.com/bio_entities/BE0004502TargetHumansLikewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368) … Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).
Polypeptides: Potassium voltage-gated channel subfamily A member 4A disintegrin and metalloproteinase with thrombospondin motifs 4
go.drugbank.com/bio_entities/BE0004687EnzymeTargetHumansCould be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4