Search
Bortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigationalBortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and
Synonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acidCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigationalIt is considered a Step 2 option on the World Health Organization's pain ladder and has about 1/10th of the potency of [morphine]. … Tramadol differs from other traditional opioid medications in that it doesn't just act as a μ-opioid agonist, but also affects monoamines by modulating the effects of neurotransmitters involved in the
Mixtures: DOR-2®, AUROMYOTRAM-P ® TABLETASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBetaxolol
go.drugbank.com/drugs/DB00195ApprovedInvestigationalA cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
Synonyms: 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol, 1-(isopropylamino)-3-[p-(cyclopropylmethoxyethyl)phenoxy]-2-propanolCategories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor AntagonistsTroglitazone
go.drugbank.com/drugs/DB00197ApprovedWithdrawnTroglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesDofetilide
go.drugbank.com/drugs/DB00204ApprovedInvestigationalDofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation
Synonyms: beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidideCategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesTrospium
go.drugbank.com/drugs/DB00209ApprovedInvestigationalTrospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: SPASMEX 5, TROSBIO® 30 MGRemikiren
go.drugbank.com/drugs/DB00212ExperimentalRemikiren is an orally active, high specificity renin inhibitor.
Categories: Heterocyclic Compounds, 1-RingEletriptan
go.drugbank.com/drugs/DB00216ApprovedInvestigationalEletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: RELPAX 40 MG FILM TABLET, 2 ADET, RELPAX 40 MG FILM TABLET, 4 ADETOxyphenonium
go.drugbank.com/drugs/DB00219ApprovedA quaternary ammonium anticholinergic agent with peripheral side effects similar to those of atropine.
International brands: A-SpasmIndinavir
go.drugbank.com/drugs/DB00224ApprovedInvestigationalA potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Synonyms: (1(1S,2R),5(S))-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-D-erythro-pentonamideCategories: P-glycoprotein inducers, P-glycoprotein inhibitors