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Prazosin
go.drugbank.com/drugs/DB00457ApprovedInvestigationalPrazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. … Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.[A176618, A176621, A176624]
Categories: prazosin and diuretics, Alpha-Adrenoreceptor Antagonists and DiureticsProducts: Nu-prazo Tab 5mg, MINIPRESS TABLET 5MGPotassium Iodide
go.drugbank.com/drugs/DB06715ApprovedInvestigationalSSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy. … Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis
Mixtures: Natalvirt Ca, Prenatal Vitamin-mineral Supplement Folic 5mgCategories: Cough and Cold PreparationsTixocortol
go.drugbank.com/drugs/DB09091ApprovedWithdrawnIt is a synthetic steroid with topical anti-inflammatory properties without the systemic glucocorticoid and mineralocorticoid activities and toxicity.[L1078] … Tixocortol is a 21-thiol derivative of hydrocortisone classified as a class A corticosteroid.
Categories: Alimentary Tract and Metabolism, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: Rectovalone 250mg/100mlZolpidem
go.drugbank.com/drugs/DB00425ApprovedInvestigationalIn addition, zolpidem improves sleep quality in patients suffering from chronic insomnia and can show mild muscle relaxant properties [L5584]. … Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia.
Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedativesSynonyms: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2-a)pyridine-3-acetamideRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnRofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. … Rofecoxib has a half-life of 17 hours and its mean oral bioavailability at therapeutically recommended doses of 125, 25, and 50 mg is approximately 93%.
Categories: Antiinflammatory and Antirheumatic Products, Antiinflammatory and Antirheumatic Products, Non-SteroidsProducts: DIEX 50MG TABLETAS, Vioxx Tab 25mgEfmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalVIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … Other drug products with similar structure and function to Efmoroctocog alfa include [DB13999], which is produced by recombinant DNA technology and is identical in sequence to endogenously produced Factor
Products: ELOCTATE® 250 UI, ELOCTATE® 1000 UIGlycopyrronium
go.drugbank.com/drugs/DB00986ApprovedInvestigationalVet approved[A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers. … gastric secretions;[L33120] as well as reducing cardiac inhibitory reflexes;[L33120] and reducing bronchoconstriction in COPD.
Mixtures: Ultibro Breezhaler 110/50mcg Inhalation Powder Hard Capsule, Xoterna Breezhaler 110/50mcg Inhalation Powder Hard CapsuleCategories: Alimentary Tract and Metabolism, formoterol and glycopyrronium bromideMetabolism and Physiological Effects of Hippuric Acid
smpdb.ca/view/SMP0123209MetabolicIt can reduce blood clotting and, in the kidney, inhibit organic acid secretion. It is associated with phenylketonuria, propionic acidemia, and tyrosinemia I (genetic metabolic disorders). … After ingestion and absorption in the gut, benzoic acid is transported into the hepatic liver cell from blood where it undergoes two metabolic reactions.
Metabolism and Physiological Effects of Phenyl glucuronide
smpdb.ca/view/SMP0123227MetabolicPhenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells. … Ultimately phenol undergoes a reaction in a liver hepatocyte through a glucuronosyltransferase enzyme to form Phenyl glucuronide.
Metabolism and Physiological Effects of Indoxyl glucuronide
smpdb.ca/view/SMP0123239MetabolicIndoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells. … Indoxyl glucuronide is shown to cause a reduction in Erythropoetin production which ultimately results in renal anemia.