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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingThe FSH receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down stream
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortIntracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingThe LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortAcetylsalicylic acid
go.drugbank.com/drugs/DB00945ApprovedInvestigationalVet approvedAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. … Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations
Synonyms: 2-Acetoxybenzoic acid, o-acetoxybenzoic acidInternational brands: St. Joseph Aspirin for AdultsMuscular Gq Protien Cascade
smpdb.ca/view/SMP0126980PhysiologicalG proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...
Drugs: CalciumEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortCinacalcet
go.drugbank.com/drugs/DB01012ApprovedInvestigationalCinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. … It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: (R)-α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine, N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amineMethazolamide
go.drugbank.com/drugs/DB00703ApprovedA carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Categories: Heterocyclic Compounds, 1-RingDobutamine
go.drugbank.com/drugs/DB00841ApprovedInvestigationalA beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Mixtures: DOCARIP® 1 MG/MLCategories: Adrenergic alpha-1 Receptor Agonists, Adrenergic beta-1 Receptor AgonistsErgotamine
go.drugbank.com/drugs/DB00696ApprovedA vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Mixtures: FENCAFEN®TABLETAS, MIGRADOL® TABLETACategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsP2 Purinoceptors
go.drugbank.com/bio_entities/BE0009827TargetThe affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP … G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues.
Polypeptides: S-geranylgeranyl-glutathione receptor P2RY8gamma-Glutamyltransferase Deficiency
smpdb.ca/view/SMP0000183DiseaseGamma-Glutamyltransferase Deficiency is an autosomal recessive disorder caused by a mutation in the GGT1 gene which codes for gamma-glutamyltranspeptidase 1. A deficiency in this enzyme results in accumulation of L-cysteine, gamma-glutam...
Enzymes: Glutathione S-transferase omega-2