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Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen
go.drugbank.com/drugs/DB16709Approved[L35505] It was developed as an alternative to autografting - the process by which a patient's own skin is harvested and grafted onto the burn site - which has the disadvantage of creating a new wound … The product does not remain permanently engrafted, instead being replaced by the patient's own cells over time, which can reduce or even eliminate the need for autografting.
Phenazopyridine
go.drugbank.com/drugs/DB01438ApprovedInvestigationalIngestion of phenazopyridine is found to change the appearance of the urine by imparting an orange or red color, as it is considered an azo dye.[L7829] … Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during
Synonyms: 2,6-Diamino-3-phenylazopyridine, 2,6-Diamino-3-(phenylazo)pyridineCategories: Heterocyclic Compounds, 1-RingEstetrol
go.drugbank.com/drugs/DB12235ApprovedInvestigational[L33184] Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but can be synthesized from a plant source and used for contraception. … The combination of drospirenone and estetrol offers a new choice with a favourable safety profile for women seeking contraceptive therapy.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCitric acid
go.drugbank.com/drugs/DB04272ApprovedInvestigationalNutraceuticalVet approvedA key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. … Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.
Synonyms: 3-carboxy-3-hydroxypentane-1,5-dioic acid, 2-Hydroxytricarballylic acidMixtures: Sal de Uvas Picot, Sal de Uvas PicotL-Glutamine
go.drugbank.com/drugs/DB00130ApprovedInvestigationalNutraceuticalIt is the principal carrier of nitrogen in the body and is an important energy source for many cells. … A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia.
Synonyms: L-Glutaminsäure-5-amid, L-glutamic acid γ-amideInternational brands: L-Glutamine PowerSevabertinib
go.drugbank.com/drugs/DB21667ApprovedInvestigational[L54638] Sevabertinib functions as a reversible kinase inhibitor of human epidermal growth factor receptor 2 (HER2), also exhibiting activity against epidermal growth factor receptor (EGFR). … Sevabertinib is a kinase inhibitor indicated for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain
Categories: MATE 2-K Inhibitors, MATE 1 InhibitorsAME-527
go.drugbank.com/drugs/DB05879ExperimentalAME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. … AME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding properties.
Mepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalMepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma and marketed under the brand name Nucala by GlaxoSmithKline. … Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote fibrosis, all of which contribute to the multifactorial symptomatology of hypereosinophilic diseases
Categories: Interleukin-5 AntagonistProducts: NUCALA® 100MG/ML SOLUCION INYECTABLE, Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (1 adet)Glimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalThe main effect of SUs is thought to be effective when residual pancreatic β-cells are present,[A177715] as they work by stimulating the release of insulin from the pancreatic beta cells and they are also … 2 diabetes mellitus.
Mixtures: METGLITAL LEX 850/4 MG TABLETAS DE LIBERACIÓN PROLONGADA, METGLITAL LEX 850/4 MG TABLETAS DE LIBERACIÓN PROLONGADACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesPrednisolone acetate
go.drugbank.com/drugs/DB15566ApprovedInvestigationalVet approvedPrednisolone acetate is a [prednisolone] molecule bound to an acetate functional group by an ester bond.[L9449] Prednisolone acetate was granted FDA approval in 1955.[L9449]
Mixtures: PREFOX-T®, CONJUNTIN-S® LIQUIFILM® SUSPENSION OFTALMICA ESTERILCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates