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Displaying results 911 - 920 of 10000 in total
  1. Target

    2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

    go.drugbank.com/bio_entities/BE0000518
    TargetHumans

    Pyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
  2. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 5

    go.drugbank.com/bio_entities/BE0003730
    TargetHumans

    Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11
  3. Drug

    Tigecycline

    go.drugbank.com/drugs/DB00560
    ApprovedInvestigational

    Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.

    Synonyms: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamideProducts: TIGECLIN ® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE., TIGEVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE
  4. Target

    Potassium voltage-gated channel subfamily A member 1

    go.drugbank.com/bio_entities/BE0000781
    TargetHumans

    Regulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception … In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).

    Polypeptides: Potassium voltage-gated channel subfamily A member 1
  5. Target

    HLA class I histocompatibility antigen, A alpha chain

    go.drugbank.com/bio_entities/BE0003483
    TargetHumans

    In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive

    Polypeptides: HLA class I histocompatibility antigen, A alpha chainSynonyms: HLA-A, MHC class I antigen A*3
  6. Target

    Potassium voltage-gated channel subfamily A member 7

    go.drugbank.com/bio_entities/BE0004719
    TargetHumans

    Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with

    Polypeptides: Potassium voltage-gated channel subfamily A member 7
  7. Target

    C-type lectin domain family 14 member A

    go.drugbank.com/bio_entities/BE0005467
    TargetHumans

    Polypeptides: C-type lectin domain family 14 member A
  8. Target

    Nuclear receptor subfamily 4 group A member 3

    go.drugbank.com/bio_entities/BE0008998
    TargetHumans

    During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). … Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part

    Polypeptides: Nuclear receptor subfamily 4 group A member 3
  9. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a … Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4
  10. Target

    C-type lectin domain family 10 member A

    go.drugbank.com/bio_entities/BE0016623
    TargetHumans

    Acts as a signaling receptor at the interface of APC-T cell interactions. … Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens

    Polypeptides: C-type lectin domain family 10 member A