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Codeine
go.drugbank.com/drugs/DB00318ApprovedIllicitInvestigationalCodeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory … The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities.
Mixtures: Zodryl AC 25, Zodryl DEC 25Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalAminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.
Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household settingProducts: AMINOFILINA 250 MG / 10 ML SOLUCION INYECTABLE, อมิโนฟิลลีน 1 1/2 เกรนAstemizole
go.drugbank.com/drugs/DB00637ApprovedWithdrawnAstemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. … It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleClobetasone
go.drugbank.com/drugs/DB13158ApprovedClobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: EUMOVATE % 0,05 KREM, 25 GR, EUMOVATE % 0,05 MERHEM, 25 GRQuinidine
go.drugbank.com/drugs/DB00908ApprovedQuinidine is a D-isomer of [quinine] present in the bark of the Cinchona tree and similar plant species. … This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication.
Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household settingSynonyms: (S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol, 6-methoxy-α-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanolVilazodone
go.drugbank.com/drugs/DB06684ApprovedInvestigationalVilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. … Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Categories: Serotonin 5-HT1 Receptor Agonists, Heterocyclic Compounds, 2-RingProducts: ZİLADONE 20 MG FİLM KAPLI TABLET, 30 ADET, ZİLADONE 10 MG FİLM KAPLI TABLET, 30 ADETLevamlodipine
go.drugbank.com/drugs/DB09237ApprovedInvestigationalLevamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. … [A188940] Levamlodipine was granted FDA approval on 19 December 2019.[L10833]
Mixtures: VOLTRAMOS 5 MG/160 MG FILM KAPLI TABLET, 28 ADET, ALENCAL VALS 5/320 MG TABLETAS RECUBIERTASCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSecukinumab
go.drugbank.com/drugs/DB09029ApprovedInvestigational[A249840] Following its first global approval in Japan in December 2014, secukinumab was approved by the European Commission on January 15, 2015, and by the FDA a few days after (January 21, 2015). … Secukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque
Products: VERXANT 150 MG/1 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 2 ADET, Verxant 300 mg / 2 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 adetSuvorexant
go.drugbank.com/drugs/DB09034ApprovedInvestigationalSuvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: BELSOMRA® 15 MG, BELSOMRA® 20 MGLactic acid
go.drugbank.com/drugs/DB04398ApprovedInvestigationalVet approvedLactic acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120] … A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation.
Mixtures: EXTRANEAL PERITONEAL DIALYSIS SOLUTION 75 g/l, Dextrose and Electrolyte No. 75Synonyms: 2-Hydroxypropanoic acid, 2-Hydroxypropionic acid