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Displaying results 941 - 950 of 10000 in total
  1. Drug

    Olmesartan

    go.drugbank.com/drugs/DB00275
    ApprovedInvestigational

    angiotensin I to angiotensin II through inhibition of the ACE enzyme. … [A175330] It was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.[A175345, L12882]

    Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acidMixtures: OPENVAS CO, ALMETEC-CO
  2. Indication

    Acute Non-Lymphocytic Leukemia

    go.drugbank.com/conditions/DBCOND0038781
    Drugs: Tioguanine
    Synonyms: Acute myeloid leukemia, no ICD-O subtype (morphologic abnormality), Acute myeloid leukemia, no International Classification of Diseases for Oncology subtype
  3. Indication

    Cutaneous Melanoma

    go.drugbank.com/conditions/DBCOND0040978
    Drugs: Ipilimumab
    Synonyms: Malignant melanoma, no ICD-O subtype, Malignant melanoma, no International Classification of Diseases for Oncology subtype
  4. Indication

    Melanoma

    go.drugbank.com/conditions/DBCOND0020306
    Drugs: Dabrafenib · Nivolumab · Peginterferon alfa-2b · Trametinib
    Synonyms: Malignant melanoma, no ICD-O subtype, Malignant melanoma, no International Classification of Diseases for Oncology subtype
  5. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    [L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways … Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesInternational brands: Risperidal M-Tab
  6. Drug

    Maleic acid

    go.drugbank.com/drugs/DB04299
    Investigational

    Synonyms: cis-but-2-enedioic acid, (Z)-2-butenedioic acid
  7. Drug

    Acarbose

    go.drugbank.com/drugs/DB00284
    ApprovedInvestigational

    Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. … [L31668] This class of antidiabetic therapy is not widely used due to their relatively modest impact on A1c, their requirement for thrice-daily dosing, and the potential for significant gastrointestinal

    Categories: Drugs Used in DiabetesProducts: GLUCOBAY® 50MG TABLETAS, GLUCOBAY® 100MG TABLETAS
  8. Target

    Proteasome subunit beta type-2

    go.drugbank.com/bio_entities/BE0002349
    TargetHumans

    This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex) … 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no

    Synonyms: Macropain subunit C7-I, Proteasome component C7-I
  9. Target

    Transcobalamin-1

    go.drugbank.com/bio_entities/BE0000238
    TargetTransporterCarrierHumans

    Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach

    Synonyms: TC I, Transcobalamin I
  10. Target

    Calcitonin gene-related peptide 1

    go.drugbank.com/bio_entities/BE0001103
    TargetHumans

    CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

    Synonyms: CGRP-I, Calcitonin gene-related peptide I