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Displaying results 941 - 950 of 10000 in total

Drug
Poloxamer 188
go.drugbank.com/drugs/DB11333
Approved
P188 was originally approved by the FDA in the 1960s as a therapeutic agent to reduce viscosity in the blood before transfusions, however it is no longer available in any approved products [A27217]. … The ability of P188 in attenuating membrane damage and cell injury has been demonstrated in a variety of _in vivo_ and _in vitro_ models [A27218].
Categories: Compounds used in a research, industrial, or household setting
Drug
Gliquidone
go.drugbank.com/drugs/DB01251
Approved
It is an ATP-dependent K+ (KATP) channel blocker.
Categories: Drugs Used in Diabetes
Drug
Fomepizole
go.drugbank.com/drugs/DB01213
ApprovedVet approved
Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. … Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Categories: Compounds used in a research, industrial, or household setting
Drug
Zinc chloride
go.drugbank.com/drugs/DB14533
Approved
Zinc chloride is a solution of ions indicated for use in total parenteral nutrition to maintain zinc levels and prevent deficiency syndromes.
Mixtures: Addamel N, ADDAMEL NCategories: Compounds used in a research, industrial, or household setting
Drug
Voclosporin
go.drugbank.com/drugs/DB11693
ApprovedInvestigational
Within 10 years of being diagnosed with SLE, 5-20% of those suffering from LN develop end-stage kidney disease, a fatal condition. … LN is a significant cause of renal failure, morbidity, and death in patients with SLE.
Drug
Influenza A virus A/Singapore/INFIMH-16-0019/2016 IVR-186 (H3N2) antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB14587
ApprovedInvestigational
Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals. … In contrast, live vaccines are produced from "wild-type" or disease-causing viruses that have been attenuated, or weakened, through various laboratory techniques.
Mixtures: Efluelda Tetra Injektionssuspension in einer Fertigspritze, SKYCellflu Trivalent Solution for Injection in Prefilled Syringe 0.25ml
Drug
Rosiglitazone
go.drugbank.com/drugs/DB00412
ApprovedInvestigational
Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. … Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and inhibitor (IκB) levels increase in patients on rosiglitazone.
Categories: Drugs Used in Diabetes
Drug
Methenamine
go.drugbank.com/drugs/DB06799
ApprovedInvestigationalVet approved
In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Mixtures: UR N-C Urinary Antiseptic, All-In-One UTI Emergency Kit
Drug
Iomeprol
go.drugbank.com/drugs/DB11705
ApprovedInvestigational
[A265090,A265095] Iomeprol first appeared in the market in 1994 [A265095] and is currently used in various diagnostic processes involving x-ray imaging and computed tomography (CT) scans.[L52260]
Synonyms: N,N'-BIS(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODO-5-(N-METHYLGLYCOLAMIDO)ISOPHTHALAMIDE, 1,3-BENZENEDICARBOXAMIDE, N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-((HYDROXYACETYL)METHYLAMINO)-2,4,6-TRIIODO-Categories: Compounds used in a research, industrial, or household setting
Drug
Patisiran
go.drugbank.com/drugs/DB14582
Approved
Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220]. … The approval for Onpattro was granted to Alnylam Pharmaceuticals, Inc. in August of 2018. Onpattro has been granted Fast Track, Priority Review and Breakthrough Therapy, and Orphan Drug designations.
Categories: Compounds used in a research, industrial, or household setting