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Ponatinib
go.drugbank.com/drugs/DB08901ApprovedInvestigationalPonatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Categories: Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexProducts: ICLUSIG TABLET 15 MG, ICLUSIG® 15 MG TABLETAS RECUBIERTASClofazimine
go.drugbank.com/drugs/DB00845ApprovedInvestigationalWithdrawntreatments such as [rifampicin] and [isoniazid]. … Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy.
Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: CLOFZIMIN® 100 MG, Fazim 50 mg CapsuleChlorpropamide
go.drugbank.com/drugs/DB00672ApprovedWithdrawnDue to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. … Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: ANTI-D TABLET 250 mg, ORBİN 250 MG TABLET, 100 ADETGuanfacine
go.drugbank.com/drugs/DB01018ApprovedInvestigationalGuanfacine, or BS 100-141,[A189838,A189841] is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension[L11274] but is now indicated as an extended release
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Ag-guanfacine XR, GUAGO 1 MG UZATILMIŞ SALIMLI TABLET, 7 ADETGentian violet cation
go.drugbank.com/drugs/DB00406ApprovedA dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.
Mixtures: Kerr 100 Triple Dye Dispos-AProducts: VIOJEN 10 ML SOLUSYON, De LA Cruz Gentian VioletZofenopril
go.drugbank.com/drugs/DB13166ApprovedInvestigationalZofenopril is employed as both a cardioprotective and anti-hypertensive agent. It is an angiotensin-converting enzyme (ACE) inhibitor.
Mixtures: Zofenil plus 30 mg/12,5 mg Filmtabletten, ZOPROTEC PLUS 30 MG/12.5 MG FILM KAPLI TABLET, 28 ADETProducts: Zofenil 15 mg Filmtabletten, BIFRIL 15 MG (FILM-COATED TABLETS)Varenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalA full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … The FDA said it is keeping the black box in place at least until the results of the trial are announced.
Mixtures: CHAMPIX 0,5 MG 1 MG FILM KAPLI TABLET, 11 VE 14 ADET, CHAMPIX 0,5 MG 1 MG FILM KAPLI TABLET, 11 VE 14 ADETProducts: CHAMPIX 1.0 MG TABLETAS RECUBIERTAS, CHAMPIX 1 MG FILM KAPLI TABLET, 28 ADETSulindac
go.drugbank.com/drugs/DB00605ApprovedInvestigationalSulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. … This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted
Products: Sulindac-150 Tab 150mg, CLINORIL 200 MG TABLETASRibavirin
go.drugbank.com/drugs/DB00811ApprovedInvestigationalAddition of weight-based ribavirin to Technivie therapy increased sustained virologic response after 12 weeks of daily therapy (SVR12) from 90% to 97% in patients with HCV genotype 1a and 90.9% to 100% … The potential use of ribavirin as a treatment for acute myeloid leukemia is currently under investigation.
Mixtures: Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules)Synonyms: 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamideAbrocitinib
go.drugbank.com/drugs/DB14973ApprovedInvestigational[A244549] Abrocitinib was approved by the European Commission on December 10, 2021, for the treatment of moderate-to-severe atopic dermatitis (AD) in adults who are candidates for systemic therapy. … Abrocitinib is an oral small-molecule inhibitor of Janus kinase 1 (JAK1).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: CIBINQO® 50 MG, CİBİNQO 100 MG FİLM KAPLI TABLET, 28 ADET