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Displaying results 961 - 970 of 10000 in total
  1. Target

    Cholesterol 24-hydroxylase

    go.drugbank.com/bio_entities/BE0010886
    TargetEnzymeHumans

    Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697

    Polypeptides: Cholesterol 24-hydroxylaseSynonyms: Cholesterol 24-monooxygenase
  2. Drug

    Azelaic acid

    go.drugbank.com/drugs/DB00548
    ApprovedInvestigational

    Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. … It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.

    Mixtures: 2% Salicylic Acid FACIAL CLEANSER, Azelaic Acid 15% / Niacinamide 4%Synonyms: n-nonanedioic acid
  3. Drug

    Semaglutide

    go.drugbank.com/drugs/DB13928
    ApprovedInvestigational

    [A186053] In June 2021, semaglutide was approved by the FDA for chronic weight management in adults with general obesity or overweight who have at least one weight-related condition, marking semaglutide … Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.

    Categories: Drugs Used in DiabetesProducts: WEGOVY® 0.5-1.0 MG/DOSIS (1.34 MG/ML), Wegovy® 2.4 mg/0.75 mL (2.4 mg/dose) Solution for injection in pre-filled pen
  4. Drug

    Tolvaptan

    go.drugbank.com/drugs/DB06212
    ApprovedInvestigational

    FDA approved on May 19, 2009.

    Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: SAMSCA 30 MG TABLET, 10 ADET, SAMSCA 15 MG TABLET, 10 ADET
  5. Pathway

    Acylcarnitine (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoylcarnitine

    smpdb.ca/view/SMP0123550
    Metabolic

    membrane to once again form (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoyl-CoA and L-carnitine. (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl] … (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoylcarnitine is an acylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
  6. Drug

    Daunorubicin

    go.drugbank.com/drugs/DB00694
    ApprovedInvestigational

    A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione
  7. Drug

    Gadopentetic acid

    go.drugbank.com/drugs/DB00789
    ApprovedInvestigational

    (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) … A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs.

    Categories: Compounds used in a research, industrial, or household settingProducts: MAGNEVIST FLAKON, 10 ML, EMARAY IV ENJEKSIYONLUK COZELTI ICEREN FLAKON 10 ML
  8. Drug

    Diatrizoate

    go.drugbank.com/drugs/DB00271
    ApprovedVet approved

    As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.

    Mixtures: UROGRAFIN %76 IV ENJEKSIYON VE INFUZYON ICIN COZELTI, 100 ML, UROGRAFIN %76 IV ENJEKSIYON VE INFUZYON ICIN COZELTI, 50 MLCategories: Compounds used in a research, industrial, or household setting
  9. Drug

    Tretinoin

    go.drugbank.com/drugs/DB00755
    ApprovedInvestigationalNutraceutical

    [A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. … [A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism.

    Mixtures: Acnatac 10 mg/g + 0,25 mg/g Gel, CLİNDATRE 12 MG/G + 0,25 MG/G JEL, 30 GRAMCategories: Retinoids for Topical Use in Acne, Cytochrome P-450 Substrates
  10. Drug

    Burosumab

    go.drugbank.com/drugs/DB14012
    ApprovedInvestigational

    Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic … It causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346].

    Categories: Fibroblast Growth Factor-23 Blocking AntibodiesProducts: CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML, CRYSVITA 10 MG SOLUTION FOR INJECTION