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GDNF family receptor alpha-1
go.drugbank.com/bio_entities/BE0013583TargetHumansGDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977)
Polypeptides: GDNF family receptor alpha-1Synonyms: GDNF receptor alpha-1, TGF-beta-related neurotrophic factor receptor 1Corticotropin-releasing hormone receptor 2
go.drugbank.com/bio_entities/BE0014244TargetHumansG protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579 … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (PubMed:32004470, PubMed:36335102
Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: Corticotropin-releasing factor receptor 2Interleukin-10 receptor subunit alpha
go.drugbank.com/bio_entities/BE0014391TargetHumansCell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Polypeptides: Interleukin-10 receptor subunit alphaSynonyms: IL-10 receptor subunit alpha, Interleukin-10 receptor subunit 1G protein-coupled receptor 68
go.drugbank.com/bio_entities/BE0014724TargetHumansThe receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed
Polypeptides: G protein-coupled receptor 68Synonyms: G protein-coupled receptor 12A, Ovarian cancer G protein-coupled receptor 1G protein-coupled receptor 84
go.drugbank.com/bio_entities/BE0020007TargetHumansIn immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses … G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14.
Polypeptides: G protein-coupled receptor 84Synonyms: Inflammation-related G protein-coupled receptor EX33Aluminum zirconium trichlorohydrex gly
go.drugbank.com/drugs/DB11116ApprovedWithdrawnAluminum zirconium trichlorohydrex gly is a common active ingredient in deodorant and antiperspirant products for the over-the-counter use.
Sonidegib
go.drugbank.com/drugs/DB09143ApprovedInvestigationalSonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma.
Categories: Smoothened Receptor AntagonistsStem bromelain
go.drugbank.com/drugs/DB12249ApprovedThe primary therapeutic use for which stem bromelain is currently and formally indicated is as a burn wound eschar debridement agent that has been approved by the EMA since 2012 and marketed under the brand name Nexobrid [FDA Label]. Bro...
Oxcarbazepine
go.drugbank.com/drugs/DB00776ApprovedInvestigational[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood … [A186011] Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing
Trospium
go.drugbank.com/drugs/DB00209ApprovedInvestigational[L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.