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Displaying results 961 - 970 of 10000 in total
  1. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Plays a role in the vascular response to injury (By similarity)

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1
  2. Target

    Inositol polyphosphate-4-phosphatase type I A

    go.drugbank.com/bio_entities/BE0018619
    EnzymeHumans

    Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15716355, PubMed:20463662). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). ...

    Polypeptides: Inositol polyphosphate-4-phosphatase type I A
  3. Target

    Vascular endothelial growth factor A, long form

    go.drugbank.com/bio_entities/BE0000163
    TargetHumans

    Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (By similarity)

    Polypeptides: Vascular endothelial growth factor A, long form
  4. Target

    3-hydroxy-3-methylglutaryl-coenzyme A reductase

    go.drugbank.com/bio_entities/BE0001856
    TargetPseudomonas mevalonii

    P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.

    Polypeptides: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
  5. Target

    V-type proton ATPase catalytic subunit A

    go.drugbank.com/bio_entities/BE0009200
    TargetPlasmodium falciparum (isolate 3D7)

    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates

    Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit A
  6. Drug

    Dimenhydrinate

    go.drugbank.com/drugs/DB00985
    ApprovedInvestigational

    [L32980,L32985,L32995] Dimenhydrinate is a combination of [Diphenhydramine] and [8-chlorotheophylline] in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline. … [A33889] When used in large doses, dimenhydrinate has been shown to cause a "high" characterized by hallucinations, excitement, incoordination, and disorientation.

    Synonyms: 8-chloro-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1), N,N-dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinateInternational brands: Vomex A
  7. Drug

    Pegfilgrastim

    go.drugbank.com/drugs/DB00019
    ApprovedInvestigational

    [L9974] NIOPEG (pegfilgrastim), a biosimilar of NEULASTA®, was approved by Health Canada in April 2024 for the prevention of febrile neutropenia in patients with non-myeloid malignancies receiving myelosuppressive … [A29,A187607] Due to a longer half-life and slower elimination rate than filgrastim, pegfilgrastim requires less frequent dosing than filgrastim; however, pegfilgrastim has a comparable pharmacological

    Categories: Compounds used in a research, industrial, or household setting, Complex MixturesSynonyms: 吉新芬, PEG-G-CSF
  8. Drug

    Pralidoxime

    go.drugbank.com/drugs/DB00733
    ApprovedInvestigationalVet approved

    Pralidoxime is an antidote to organophosphate pesticides and chemicals. … If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase

    Categories: Compounds used in a research, industrial, or household settingSynonyms: 2-PAM
  9. Drug

    Bortezomib

    go.drugbank.com/drugs/DB00188
    ApprovedInvestigational

    Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
  10. Drug

    Citrus bioflavonoids

    go.drugbank.com/drugs/DB14586
    Approved

    Mixtures: Nutriforte Non-Acidic Vitamin C 1000 mg with Bioflavonoids, NATURERICH ESTER-C COMPLEX TABLETSCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring