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Displaying results 971 - 980 of 10000 in total

Drug
Benserazide
go.drugbank.com/drugs/DB12783
ApprovedInvestigational
When levodopa is used by itself as a therapy for treating Parkinson's disease, its ubiquitous metabolism into dopamine is responsible for a resultant increase in the levels of circulating dopamine in the … This can result in a number of side effects like nausea, vomiting, or even cardiac arrhythmias that may diminish patient adherence [F2, L2553].
Mixtures: MADOPAR®, MADOPAR®Categories: Aromatic L-amino Acid Decarboxylase Inhibitors
Drug
Pegvaliase
go.drugbank.com/drugs/DB12839
ApprovedInvestigational
to 3690 µmol/L [A33286]. … The presence of a PEG moiety in pegvaliase-pqpz allows a reduced immune response and improved pharmacodynamic stability [A33284].
Drug
Reproterol
go.drugbank.com/drugs/DB12846
Investigational
Reproterol has been used in trials studying the treatment of Asthma, Exercise-Induced.
Synonyms: 7-(3-((2-(3,5-Dihydroxyphenyl)-2-hydroxyethyl)amino)propyl)theophyllineCategories: Heterocyclic Compounds, 2-Ring, Selective Beta 2-adrenergic Agonists
Drug
Quizartinib
go.drugbank.com/drugs/DB12874
ApprovedInvestigational
maintenance monotherapy resulted in a 22% reduction in the risk of death. … [A260641] Additionally, quizartinib also demonstrates inhibitory activity toward FLT3 with internal tandem duplication (ITD), although with a 10-fold lower affinity compared to wild-type FLT3.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
Drug
RO-4987655
go.drugbank.com/drugs/DB12933
Investigational
RO4987655 has been used in trials studying the treatment of Neoplasms.
Categories: Heterocyclic Compounds, 1-Ring
Drug
Pyronaridine
go.drugbank.com/drugs/DB12975
Investigational
Pyronaridine has been investigated for the treatment of Malaria.
Categories: Heterocyclic Compounds, 2-Ring
Drug
Biapenem
go.drugbank.com/drugs/DB13028
Investigational
It is a carbapenem antibiotic with a methyl group on the 1-beta position, which gives it stability against degradation by dehydropeptidase I.[A275008]
Categories: Heterocyclic Compounds, 2-Ring
Drug
Tramazoline
go.drugbank.com/drugs/DB13064
Investigational
Tramazoline is under investigation in clinical trial NCT01601509 (Nasal Tramazoline and Dexamethazone in Obstructive Sleep Apnea (OSA) Patients Tramazoline and).
Categories: Heterocyclic Compounds, 1-Ring
Drug
Macimorelin
go.drugbank.com/drugs/DB13074
Approved
The diagnosis of AGHD requires biochemical confirmation with at least 1 GH stimulation test [A31481]. … Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
Drug
Zidebactam
go.drugbank.com/drugs/DB13090
Approved
Zidebactam is a diazabicyclooctane that acts both as a beta-lactamase inhibitor and as an antibacterial in its own right, selectively binding penicillin-binding protein 2. … [L63350] It is available only in fixed combination with [cefepime], which binds PBP3 and PBP1a/b.
Categories: Heterocyclic Compounds, 1-Ring