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Displaying results 971 - 980 of 10000 in total
  1. Drug

    Loteprednol etabonate

    go.drugbank.com/drugs/DB14596
    Approved

    As a nasal spray, it can be used for the treatment and management of seasonal allergic rhinitis. … Most prescription LE products, however, tend to be indicated for the treatment of post-operative inflammation and pain following ocular surgery [FDA Label].

    Mixtures: TOBRALOT 5 MG+3 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, LOTEMICIN®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  2. Target

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

    go.drugbank.com/bio_entities/BE0011403
    TargetHumans

    Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate … Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well (PubMed:12846830).

    Synonyms: Alkaline phosphodiesterase I, Phosphodiesterase I beta
  3. Drug

    Desloratadine

    go.drugbank.com/drugs/DB00967
    ApprovedInvestigational

    Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. … It is the active descarboethoxy metabolite of loratidine (a second generation histamine).

    Mixtures: NEUMOLEX® NF, BUCOXOL ® GRIP MAX CAPSULAS DURAS CON CONTENIDO LIQUIDOCategories: Histamine H1 Antagonists, Non-Sedating, P-glycoprotein inhibitors
  4. Drug

    Respiratory syncytial virus vaccine, adjuvanted

    go.drugbank.com/drugs/DB17762
    ApprovedInvestigational

    Arexvy (respiratory syncytial virus vaccine, adjuvanted) is an adjuvanted vaccine developed by GlaxoSmithKline Biologicals. … [L46352] It was also later approved by Health Canada on August 4, 2023,[L47666] and the EMA in March 2025.[L52380]

    Synonyms: RECOMBINANT RESPIRATORY SYNCYTIAL VIRUS PRE-FUSION F PROTEIN, RESPIRATORY SYNCYTIAL VIRUS PREFUSION F PROTEIN (RSVPREF3)
  5. Drug

    Levomenthol

    go.drugbank.com/drugs/DB00825
    ApprovedInvestigational

    Menthol mediates anesthetic properties and anti-irritating properties locally, thus it is widely used to relieve minor throat irritations. … Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.

    Mixtures: CHAP ICE (R) MEDICATED, Ken- Ku Oil Cap Pancor MasCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  6. Drug

    Haloperidol

    go.drugbank.com/drugs/DB00502
    ApprovedInvestigational

    Dopamine-antagonizing medications such as haloperidol are though to improve psychotic symptoms and states that are caused by an over-production of dopamine, such as schizophrenia, which is theorized to … the least amount of side effects within this class, but demonstrates a stronger disposition for causing extrapyramidal symptoms (EPS).

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
  7. Drug

    Topiramate

    go.drugbank.com/drugs/DB00273
    ApprovedInvestigational

    Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. … [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.[A188330]

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InducersSynonyms: 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamate, 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
  8. Target

    Intron-associated endonuclease 1

    go.drugbank.com/bio_entities/BE0002953
    TargetEnterobacteria phage T4

    This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.

    Synonyms: I-TevI
  9. Target

    Synapsin-1

    go.drugbank.com/bio_entities/BE0004488
    TargetHumans

    Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed:21441247,...

    Synonyms: Synapsin I
  10. Target

    Copine-1

    go.drugbank.com/bio_entities/BE0009002
    TargetHumans

    Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calc...

    Synonyms: Copine I