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Displaying results 971 - 980 of 10000 in total
  1. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0003724
    TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  2. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008387
    TargetBacillus subtilis (strain 168)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  3. Target

    Inhibin beta A chain

    go.drugbank.com/bio_entities/BE0010139
    TargetHumans

    Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid

    Polypeptides: Inhibin beta A chainSynonyms: Activin beta-A chain
  4. Target

    Human Arylsulfatase A mRNA

    go.drugbank.com/bio_entities/BE0010214
    TargetHumans

  5. Target

    Interleukin-17 receptor A

    go.drugbank.com/bio_entities/BE0018249
    TargetHumans

    Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848) … Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495).

    Polypeptides: Interleukin-17 receptor ASynonyms: IL-17 receptor A
  6. Drug

    (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL

    go.drugbank.com/drugs/DB07707
    Experimental

    Synonyms: (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
  7. Drug

    Haloperidol

    go.drugbank.com/drugs/DB00502
    ApprovedInvestigational

    In addition, they block many receptors other than the primary target (dopamine receptors), such as cholinergic or histaminergic receptors, resulting in a higher incidence of side effects such as sedation … be caused by a hyperdopaminergic state within the limbic system of the brain.

    Synonyms: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-oneInternational brands: Einalon S
  8. Indication

    Chronic Motor and Vocal Tic Disorder

    go.drugbank.com/conditions/DBCOND0082272
    Drugs: Aripiprazole
    Synonyms: Gilles de la Tourette, Gilles de La Tourette's Disease
  9. Drug

    Daunorubicin

    go.drugbank.com/drugs/DB00694
    ApprovedInvestigational

    A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.

    Synonyms: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione, Leukaemomycin CCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  10. Drug

    Vincristine

    go.drugbank.com/drugs/DB00541
    ApprovedInvestigational

    Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).

    Mixtures: MEODEX®, MEODEX®Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, BSEP/ABCB11 Substrates with a Narrow Therapeutic Index