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Displaying results 981 - 990 of 1640 in total
  1. Target

    Nuclear receptor subfamily 1 group D member 2

    go.drugbank.com/bio_entities/BE0009348
    TargetHumans

    Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. … Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced

    Polypeptides: Nuclear receptor subfamily 1 group D member 2Synonyms: Rev-erb alpha-related receptor, Orphan nuclear hormone receptor BD73
  2. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic ...

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4
  3. Target

    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

    go.drugbank.com/bio_entities/BE0020703
    TargetHumans

    Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232).

    Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  4. Drug

    Plasma protein fraction (human)

    go.drugbank.com/drugs/DB13968
    ApprovedInvestigational

    The plasma protein fraction human (PPFh) is defined as a sterile solution of proteins composed mainly of albumin and globulin derived from human plasma. It is already reviewed under the category of biologics by the FDA where the processi...

    Mixtures: UMAN SERUM
  5. Drug

    Salicylamide

    go.drugbank.com/drugs/DB08797
    Approved

    Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedies

  6. Drug

    Methylene blue

    go.drugbank.com/drugs/DB09241
    ApprovedInvestigational

    Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Afr...

    Mixtures: Uta, Uta
  7. Drug

    Lucanthone

    go.drugbank.com/drugs/DB04967
    Investigational

    One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.

  8. Drug

    Vecuronium

    go.drugbank.com/drugs/DB01339
    ApprovedInvestigational

    Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or

  9. Drug

    Crotalus scutulatus antivenin

    go.drugbank.com/drugs/DB13891
    Approved

    Specimens with type A venom, which cause a different pattern of injury than other rattlesnakes, have been reported in southern California, Nevada, Utah, Arizona, Texas, and New Mexico [L2856].

  10. Drug

    Afizagabar

    go.drugbank.com/drugs/DB21439
    Investigational

    Afizagabar is under investigation in clinical trial NCT02877615 (Efficacy and Safety Trial With S 44819 After Recent Ischemic Cerebral Event).

    Categories: GABA-A Receptor Antagonists