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Displaying all 3 results
  1. Pathway

    HIF-1 (Hypoxia) Signaling

    smpdb.ca/view/SMP0546631
    Signaling

    Key HIF targets include vascular endothelial growth factor (VEGF) for angiogenesis, erythropoietin (EPO) for red blood cell production, glucose transporters (GLUT1/3) and glycolytic enzymes (e.g., HK2, … Hypoxia triggers stabilization of hypoxia‑inducible factors (HIFs), oxygen‑sensitive transcription factors that orchestrate adaptive responses by inducing genes involved in angiogenesis, erythropoiesis

    Drugs: Aspartic acid · ATP · Proline · Sapropterin · Calcium · Magnesium cation +3 more
    Enzymes: Erythropoietin
  2. Pathway

    Metabolism and Physiological Effects of Putrescine

    smpdb.ca/view/SMP0123276
    Metabolic

    While putrescine is important for interactions and processes involving, DNA, RNA and proteins, at high levels it is also a protein bound uremic toxin found in the body that can inhibit erythropoietin production

    Drugs: Arginine · Ornithine · Putrescine · Urea
  3. Pathway

    Ruxolitinib Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126971
    Drug action

    JAKs have diverse functions: JAK1 and JAK3 promote lymphocyte differentiation, survival, and function, while JAK2 promotes signal transduction of erythropoietin and thrombopoietin. … JAKs play a pivotal role in intracellular signalling pathways of various cytokines and growth factors essential to hematopoiesis, such as interleukin, erythropoietin, and thrombopoietin.

    Drugs: Ruxolitinib