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Displaying all 6 results
  1. Target

    Sodium-driven chloride bicarbonate exchanger

    go.drugbank.com/bio_entities/BE0004683
    TransporterHumans

    Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). … Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange

    Polypeptides: Sodium-driven chloride bicarbonate exchangerFunction: sodium,bicarbonate
  2. Target

    Electroneutral sodium bicarbonate exchanger 1

    go.drugbank.com/bio_entities/BE0004680
    TransporterTargetHumans

    Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). … Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)

    Polypeptides: Electroneutral sodium bicarbonate exchanger 1Function: bicarbonate transmembrane transporter activity
  3. Target

    Pendrin

    go.drugbank.com/bio_entities/BE0009874
    TransporterHumans

    Sodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:11932316, PubMed:12107249, PubMed:16684826, PubMed:24051746). … Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:24051746, PubMed:35601831).

    Synonyms: Sodium-independent chloride/iodide transporterFunction: chloride transmembrane transporter activity
  4. Target

    Cystic fibrosis transmembrane conductance regulator

    go.drugbank.com/bio_entities/BE0001195
    TargetTransporterHumans

    Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810, PubMed:29393851) … May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883).

    Synonyms: cAMP-dependent chloride channel
  5. Target

    Solute carrier organic anion transporter family member 4C1

    go.drugbank.com/bio_entities/BE0003653
    TransporterTargetHumans

    Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604). Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604). … The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:19129463).

  6. Target

    Carbonic anhydrase

    go.drugbank.com/bio_entities/BE0009965
    TargetEnzymeHumans

    May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis (PubMed:15563508). … Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855).