Cystic fibrosis transmembrane conductance regulator

BE0001195ProteinHumansCFTR

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). It is acted on by 34 drugs in DrugBank.

Gene name
CFTR
UniProtKB entry
P13569Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,480 residues · 168,140 Da
Also known as
ABCC7 · ATP-binding cassette sub-family C member 7 · cAMP-dependent chloride channel · CFTR · Channel conductance-controlling ATPase

Resolves to

Protein
UniProtP13569UniProt nameCFTR_HUMAN
Gene
HGNCHGNC:1884NCBI Gene1080GenBank180332GeneCardsCFTR
Pharmacology
IUPHAR/GtoPdb707KEGGhsa:1080
Structure
PDB1XMIPDB1XMJPDB2BBO
Drugs

What you can answer from here — as of September 07, 2019

34DrugsApproved to experimental, with action, bond type and pharmacological action
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57Clinical trialsTrials of drugs acting on it, by phase and status
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24GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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161+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cystic fibrosis transmembrane conductance regulator, how selective are they, and which programs against it are still in active trials?

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