Search
Warfarin Action Pathway
smpdb.ca/view/SMP0000268Drug actionWarfarin is a drug part of the anticoagulant drug class, used to dissolve or break down blood clots. Warfarin inhibits vitamin K epoxide reductase complex subunit 1. … vitamin K epoxide reductase complex subunit 1 to become reduced vitamin K (phylloquinone), and then back to vitamin K1 2,3-epoxide continually through vitamin K-dependent gamma-carboxylase, but as warfarin
Warfarin Action Pathway (New)
smpdb.ca/view/SMP0124982Drug actionWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. … Warfarin is a [vitamin K] antagonist which acts to inhibit the production of vitamin K by inhibiting vitamin K epoxide reductase.
Apoptotic DNA Fragmentation and Tissue Homeostasis
smpdb.ca/view/SMP0063772SignalingApoptotic endonucleases degrade chromosomal DNA during programmed cell death. ICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. EndoG resides in mito...
Drugs: ZincEnzymes: High mobility group protein B1, High mobility group protein B2Cisplatin Action Pathway
smpdb.ca/view/SMP0124477Drug actionCisplatin is a chemotherapeutic alkylating agent that causes intrastand crosslinks that is more difficult to repair than regular DNA. Cisplatin diffuses into the cell either through the membrane or through metal transporter like CTR1. In...
Enzymes: High affinity copper uptake protein 1Physostigmine Action Pathway
smpdb.ca/view/SMP0125085Drug actionPhysostigmine is a cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. It is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is u...
Enzymes: High affinity choline transporter 1Trihexyphenidyl Action Pathway
smpdb.ca/view/SMP0126395Drug actionTrihexyphenidyl is an antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS). Trihexyphenidyl is a non-select...
Enzymes: High affinity choline transporter 1Physostigmine Action Pathway (new)
smpdb.ca/view/SMP0126616Drug actionPhysostigmine is a cholinesterase inhibitor used to treat glaucoma, once administered it is rapidly absorbed and can travel across membranes even the blood-brain barrier. Physostigmine acts on the acetylcholinesterase enzyme and inhibits...
Enzymes: High affinity choline transporter 1Tacrine Action Pathway (new)
smpdb.ca/view/SMP0126621Drug actionTacrine an anticholinesterase drug used primarily in the treatment of Alzheimer's disease, the drug also counters the effects of muscle relaxants, respiratory stimulants and other central nervous disorders. Its mechanism of action is not...
Enzymes: High affinity choline transporter 1Donepezil Action Pathway
smpdb.ca/view/SMP0126613Drug actionDonepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with mem...
Enzymes: High affinity choline transporter 1Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionGalantamine is a cholinesterase inhibitor used in the treatment of Alzheimer's disease, specifically to mitigate symptoms of mild to moderate dementia. These symptoms of cognitive loss are due to acetylcholine deficiency, galantamine inh...
Enzymes: High affinity choline transporter 1