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Displaying results 1 - 10 of 460 in total
  1. Target

    Melanoma antigen preferentially expressed in tumors

    go.drugbank.com/bio_entities/BE0010493
    TargetHumans

    In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin

    Polypeptides: Melanoma antigen preferentially expressed in tumors
  2. Target

    Membrane protein involved in aromatic hydrocarbon degradation

    go.drugbank.com/bio_entities/BE0003979
    TargetPseudomonas putida (strain F1 / ATCC 700007)

    Polypeptides: Membrane protein involved in aromatic hydrocarbon degradation
  3. Target

    5-oxoprolinase

    go.drugbank.com/bio_entities/BE0002268
    TargetEnzymeHumans

    Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate

    Polypeptides: 5-oxoprolinaseSynonyms: 5-OPase, 5-oxo-L-prolinase
  4. Target

    Cadherin-5

    go.drugbank.com/bio_entities/BE0003403
    TargetHumans

    Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity). … They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602).

    Polypeptides: Cadherin-5
  5. Target

    Frizzled-5

    go.drugbank.com/bio_entities/BE0014104
    TargetHumans

    Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (PubMed:26908622) … Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity).

    Polypeptides: Frizzled-5Synonyms: Fz-5
  6. Target

    5'-nucleotidase

    go.drugbank.com/bio_entities/BE0001096
    TargetEnzymeHumans

    Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:344...

    Polypeptides: 5'-nucleotidaseSynonyms: 5'-NT, 5'-deoxynucleotidase
  7. Target

    Interleukin-5

    go.drugbank.com/bio_entities/BE0001208
    TargetHumans

    Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276).

    Polypeptides: Interleukin-5Synonyms: IL-5
  8. Target

    Kallikrein-5

    go.drugbank.com/bio_entities/BE0010708
    TargetHumans

    May be involved in desquamation

    Polypeptides: Kallikrein-5
  9. Target

    Retinol dehydrogenase 5

    go.drugbank.com/bio_entities/BE0000570
    TargetEnzymeHumans

    Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). … Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:10588954, PubMed:11675386, PubMed:9115228, PubMed:9931293).

    Polypeptides: Retinol dehydrogenase 5Synonyms: Short chain dehydrogenase/reductase family 9C member 5
  10. Target

    Peroxiredoxin-5, mitochondrial

    go.drugbank.com/bio_entities/BE0000907
    TargetEnzymeHumans

    Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events

    Polypeptides: Peroxiredoxin-5, mitochondrialSynonyms: Thioredoxin-dependent peroxiredoxin 5