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Sapropterin
go.drugbank.com/drugs/DB00360ApprovedInvestigationalSapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide.
Synonyms: Sapropterin, SapropterinaSalts: Sapropterin dihydrochlorideMetabolism and Physiological Effects of O-Sulfotyrosine
smpdb.ca/view/SMP0126811MetabolicO-Sulfotyrosine belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from a reaction of phenylalanine at ...
Levomilnacipran SNRI - Serotonin Reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126386Drug actionLevomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of major depressive disorder, generalized anxiety disorder, chronic musculoske...
Fluoxetine - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126435Drug actionFluoxetine is a selective serotonin reuptake inhibitor that exerts anti-depressive effects by selectively inhibiting serotonin reuptake in the brain. One metabolite of fluoxetine, norfluoxetine (N- desmethyl fluoxetine) is biologically a...
Duloxetine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126449Drug actionDuloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. It blocks both sodium dependent serotonin and sodium dependent norepinephr...
Tiapride Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126590Drug actionTiapride is a selective D2 and D3 dopamine receptor blocker indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitati...
Milnacipran SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126399Drug actionMilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of fibromyalgia, major depressive disorder, generalized anxiety disorder, chronic musculoskeletal pain and diabetic peripheral neuropat...
Vilazodone mechanism of Action Action Pathway
smpdb.ca/view/SMP0126404Drug actionVilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known ...
Chlorpromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126487Drug actionProchlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...