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Oxytocin
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist na...
Carbetocin
go.drugbank.com/drugs/DB01282ApprovedInvestigationalIt is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.
Categories: Oxytocin and AnaloguesSynonyms: 1-butyric acid-2-(3-(p-methoxyphenyl)-L-alanine)oxytocinOxytocin receptor
go.drugbank.com/bio_entities/BE0000844TargetHumansPeripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (PubMed:6278592). … In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (PubMed:22069312, PubMed:35241813, PubMed:35851571).
Polypeptides: Oxytocin receptorFunction: oxytocin receptor activityOxytocin-neurophysin 1 proprotein
go.drugbank.com/bio_entities/BE0000751CarrierHumansPrecursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein
Polypeptides: Oxytocin-neurophysin 1 proproteinSynonyms: pro-oxytocin/neurophysinOxytocin Action Pathway
smpdb.ca/view/SMP0124714Drug actionActivation of the oxytocin receptor on the myometrial cell leading to activation of the Gq signaling cascade. … The concentration of oxytocin receptors on the myometrium increases significantly during pregnancy and reaches a peak in early labor.
Enzymes: Oxytocin receptorAtosiban
go.drugbank.com/drugs/DB09059ApprovedInvestigationalAtosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used intravenously to halt premature labor.
Gemeprost
go.drugbank.com/drugs/DB08964ApprovedWithdrawnGemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mif...
Vasopressin
go.drugbank.com/drugs/DB00067ApprovedInvestigational[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third and eighth amino acids.