Displaying drugs 3676 - 3700 of 11857 in total
Siltuximab
Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). Its use is indicated for the treatment...
Approved
Investigational
Matched Description: … Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese ... It is administered as a 1 hour intravenous infusion every 3 weeks. ... MCD is a rare blood disorder caused by dysregulated IL-6 production, proliferation of lymphocytes, and …
Fosnetupitant
In April 2018, the U.S. Food and Drug Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a fixed antiemetic combination of fosnetupitant, 235mg, and palonosetron, 0.25mg) as an alternative treatment option for patients experiencing chemotherapy-induced nausea and vomiting . Fosnetupitant is the pro-drug form...
Approved
Matched Description: … Generally, 25% to 30% of patients with a diagnosis of cancer receive chemotherapy as a treatment modality ... Administration (FDA) and the Swiss company Helsinn approved the intravenous formulation of AKYNZEO® (NEPA, a …
Gemifloxacin
Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are...
Approved
Investigational
Matched Description: … Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment …
Anisotropine methylbromide
Anisotropine methylbromide is a quaternary ammonium compound. Its use as treatment adjunct in peptic ulcer has been replaced by the use of more effective agents. Depending on the dose, anisotropine methylbromide may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary...
Approved
Matched Description: … Anisotropine methylbromide is a quaternary ammonium compound. ... activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a …
Ambrosia chamissonis pollen
Ambrosia chamissonis pollen is the pollen of the Ambrosia chamissonis plant. Ambrosia chamissonis pollen is mainly used in allergenic testing.
Approved
Medicago sativa pollen
Medicago sativa pollen is the pollen of the Medicago sativa plant. Medicago sativa pollen is mainly used in allergenic testing.
Approved
Omalizumab
Omalizumab is a recombinant DNA-derived humanized monoclonal antibody directed against human immunoglobulin E (IgE). IgE promotes the release of inflammatory mediators from mast cells and basophils during allergic and inflammatory reactions. By binding to IgE and neutralizing it, omalizumab reduces free IgE levels and prevents IgE from binding to its...
Approved
Investigational
Matched Description: … Omalizumab is a recombinant DNA-derived humanized monoclonal antibody directed against human immunoglobulin ... [L50482] It is used to treat a range of immune and inflammatory conditions, including allergies, urticaria …
Oxtriphylline
Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all...
Approved
Matched Description: … Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor …
Alnus incana subsp. rugosa pollen
Alnus incana subsp. rugosa pollen is the pollen of the Alnus incana subsp. rugosa plant. Alnus incana subsp. rugosa pollen is mainly used in allergenic testing.
Approved
Fraxinus pennsylvanica pollen
Fraxinus pennsylvanica pollen is the pollen of the Fraxinus pennsylvanica plant. Fraxinus pennsylvanica pollen is mainly used in allergenic testing.
Approved
Trametinib
Trametinib is an orally bioavailable mitogen-activated extracellular signal-regulated kinase 1 (MEK1) and MEK2 inhibitor.[A258298,A258293] It was first approved by the FDA in May 2013 for the treatment of melanoma. It was later approved by Health Canada on July 18, 2013 and by the European Commission on June 30, 2014. Trametinib...
Approved
Matched Description: … [L45583] Trametinib is currently approved to treat a variety of cancers with BRAF mutations, such as ... non-small cell lung cancer and thyroid cancer, as monotherapy or in combination with [dabrafenib], a …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Neomycin
Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of Streptomyces fradiae. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as framycetin, is the most active component of the complex and neomycin C is the isomer...
Approved
Vet approved
Matched Description: … [L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C. ... [A175042,A191529] Neomycin A, or [neamine], is a moiety that conjoins two molecules of neomycin B and ... Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products …
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …
Matched Categories: … Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …
Liraglutide
Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid...
Approved
Matched Description: … a GLP-1 receptor agonist. ... [A6932] Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer ... Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as …
Moxifloxacin
Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Approved
Investigational
Matched Description: … Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. …
Casuarina equisetifolia pollen
Casuarina equisetifolia pollen is the pollen of the Casuarina equisetifolia plant. Casuarina equisetifolia pollen is mainly used in allergenic testing.
Approved
Arrhenatherum elatius pollen
Arrhenatherum elatius pollen is the pollen of the Arrhenatherum elatius plant. Arrhenatherum elatius pollen is mainly used in allergenic testing.
Approved
Artemisia dracunculus pollen
Artemisia dracunculus pollen is the pollen of the Artemisia dracunculus plant. Artemisia dracunculus pollen is mainly used in allergenic testing.
Approved
Streptozocin
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Approved
Investigational
Elexacaftor
Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It received FDA approval in October 2019 in combination with tezacaftor and ivacaftor as the combination product TrikaftaTM. Elexacaftor is considered a next-generation CFTR corrector as it possesses both a different structure...
Approved
Investigational
Matched Description: … [L9395] Elexacaftor is considered a next-generation CFTR corrector as it possesses both a different structure ... Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis ... A187361] While dual corrector/potentiator combination therapy has proven useful in the treatment of a …
Cycrimine
Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Approved
Matched Description: … Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment …
Gemtuzumab ozogamicin
Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody [FDA Label]. The antibody is specifically...
Approved
Investigational
Matched Description: … Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin ... derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ... lower dosing regimen and a different schedule in combination with chemotherapy or on its own [L941]. …
Displaying drugs 3676 - 3700 of 11857 in total