Displaying drugs 826 - 850 of 11761 in total
Thiopental
A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not...
Approved
Vet approved
Matched Description: … A barbiturate that is administered intravenously for the induction of general anesthesia or for the production …
Matched Categories: … Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index …
Matched Categories: … Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index …
Deferasirox
Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …
Tetradecyl hydrogen sulfate (ester)
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins .
Sodium tetradecyl sulfate has been widely used since the 1950s, and in...
Approved
Matched Description: … 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035]. ... sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a ... surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a …
Tildrakizumab
Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows promise in the evolution of treatment strategy in chronic plaque psoriasis .
The Food and Drug Administration (FDA) approved ILUMYA (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy...
Approved
Investigational
Matched Description: … A study was performed on the pharmacokinetics of this drug on various ethnicities. ... Tildrakizumab is a high-affinity, humanized, IgG1 κ antibody targeting interleukin 23 p19 that shows ... The approved recommended dosage of ILUMYA is a subcutaneous injection of 100 mg at Weeks 0, 4, and every …
Corydalis ambigua tuber
Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Matched Description: … Corydalis ambigua tuber is a plant/plant extract used in some OTC (over-the-counter) products. …
Moxonidine
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown...
Approved
Investigational
Matched Description: … Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild …
Chlorpropamide
Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class...
Approved
Investigational
Mitapivat
Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Description: … Mitapivat is a novel, first-in-class pyruvate kinase activator. ... It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival ... first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a …
Belzutifan
Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers. The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. Initially considered to be undruggable,...
Approved
Investigational
Matched Description: … HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a ... [L36105] Initially considered to be undruggable, a binding pocket was eventually discovered in the HIF ... to the initial development of belzutifan (at the time called PT2977), which was further developed by a …
Terbutaline
Terbutaline was first synthesized in 1966 and described in the literature in the late 1960s and early 1970s. It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098]
Terbutaline was granted FDA approval on 25 March 1974.
Approved
Matched Description: … [A230328] It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients. …
Reslizumab
Reslizumab is a humanized interleukin-5 (IL-5) antagonist monoclonal antibody (IgG4 kappa) that is produced by recombinant DNA technology in murine myeloma non-secreting 0 (NS0) cells. IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment, activation, and survival of eosinophils [FDA Label]. Elevated levels of eosinophils...
Approved
Investigational
Matched Description: … Reslizumab is a humanized interleukin-5 (IL-5) antagonist monoclonal antibody (IgG4 kappa) that is produced ... IL-5 is a pro-inflammatory cytokine that is responsible for the growth and differentiation, recruitment ... Asthma is a chronic respiratory disease that causes inflammation in the lungs with asthma attacks that …
Fruquintinib
Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Description: … The first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody. ... Therefore, the advent of fruquintinib, a new generation of VEGFR inhibitors with a high kinome selectivity ... Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis …
Rozanolixizumab
Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange. It is investigated for use in autoimmune and alloimmune diseases with pathologic IgG, particularly generalized myasthenia...
Approved
Investigational
Matched Description: … Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody ... [A260192] As a result, the main clinical manifestation of myasthenia gravis is easily fatigable or persistent …
Levamlodipine
Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlodipine and levamlodipine may be used interchangeably as both...
Approved
Investigational
Matched Description: … Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], ... [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine …
Varicella zoster vaccine (live/attenuated)
Live attenuated zoster vaccine is available as two products: Zostavax for the prevention of shingles in immunocompetent people over the age of 50, and Varivax for the prevention of chickenpox in individuals 12 months of age and older. While the two vaccines contain the same immunological components and provide protection...
Approved
Matched Description: … persistant severe nerve pain that develops as a result of chronic pain from shingles lesions. ... the same immunological components and provide protection against the same virus, Zostavax contains a ... Since October 2017, however, it has been replaced as first line therapy by Shingrix ([DB13924]), a more …
Testolactone
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Approved
Investigational
Matched Description: … An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer …
Solenopsis richteri
Solenopsis richteri allergenic extract is used in allergenic testing. It is extracted from the black imported fire ant which is native to South Amercia. The species has also been introduced in North Amercia. When stung, the bites are characterized by sterile pustules that are surrounded by reddened swelling along with...
Approved
Human vaccinia virus immune globulin
Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine who possess high titers of anti-vaccinia virus antibody [FDA Label, A33814]. The IgG fraction is purified by the anion-exchange column chromatography...
Approved
Matched Description: … Human vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG ... , which contain no preservatives - unlike prior intramuscular compounds which contained thiomersal, a ... Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human …
Elranatamab
Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs), an anti-BCMA mAb and an anti-CD3 mAb, each of which contributes one heavy chain and one light chain to drug structure. The resulting 4-chain bispecific...
Approved
Investigational
Matched Description: … Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager. ... It is a humanized immunoglobulin 2-alanine kappa antibody derived from two monoclonal antibodies (mAbs …
Benzatropine
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. The generation of...
Approved
Matched Description: … It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the ... dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. ... Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor …
Difenoxin
Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R)...
Approved
Illicit
Matched Description: … Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. ... Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. ... Motofen(R) is a brand mixture which combines atropine sulfate and difenoxin hydrochloride. …
Faricimab
Retinal vascular diseases (RVDs) such as diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO) are typically caused by retinal ischemia and subsequent neovascularization (NV).[A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of retinal NV, and many currently approved RVD therapies...
Approved
Investigational
Matched Description: … [A225985, A225990, A225995] Vascular endothelial growth factor A (VEGF-A) is a well-known mediator of ... and many currently approved RVD therapies such as [aflibercept] and [ranibizumab] solely target VEGF-A. ... IgG1-derived bispecific antibody capable of simultaneously binding to and depleting VEGF-A …
Rumex acetosella pollen
Rumex acetosella pollen is the pollen of the Rumex acetosella plant. Rumex acetosella pollen is mainly used in allergenic testing.
Approved
Rumex altissimus pollen
Rumex altissimus pollen is the pollen of the Rumex altissimus plant. Rumex altissimus pollen is mainly used in allergenic testing.
Approved
Ceftobiprole
Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially as the prodrug ceftobiprole medocaril. Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of Staphylcoccus aureus (methicillin-resistant Staphylococcus aureus; MRSA).
The EMA's Committee for Medicinal Products for Human Use (CHMP)...
Approved
Investigational
Matched Description: … Ceftobiprole is a fifth-generation semisynthetic cephalosporin antibacterial which is available commercially ... Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative ... The EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a negative opinion of ceftobiprole …
Displaying drugs 826 - 850 of 11761 in total