Displaying drugs 10826 - 10850 of 11900 in total
mRNA-3745
mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs encoding human glucose 6-phosphatase (G6Pase).
Investigational
Matched Description: … mRNA-3745 is a lipid nanoparticle (LNP) encapsulated with nucleoside-modified, codon-optimized mRNAs …
Emodepside
Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively new class of anthelmintic.
Investigational
Vet approved
Matched Description: … Emodepside is an anthelmintic drug that is effective against a number of gastrointestinal nematodes, ... is licensed for use in cats and belongs to the class of drugs known as the octadepsipeptides, a relatively …
Isaralgagene civaparvovec
Isaralgagene civaparvovec, formerly known as ST-920, is liver-tropic rAAV 2/6 vector carrying the cDNA for human alpha-galactosidase A (α-Gal A) enzyme. It is developed by Sangamo Therapeutics and investigated in Fabry Disease.
Investigational
Matched Description: … (α-Gal A) enzyme. ... formerly known as ST-920, is liver-tropic rAAV 2/6 vector carrying the cDNA for human alpha-galactosidase A …
KW-7158
KW-7158 is a tricyclic compound with a non-cholingergic mechanism of action for the treatment of "urinary urgency," "frequent urination" and "urinary incontinence" associated with bladder overactivity (involuntary abnormal contraction of the bladder). The therapeutic effects of KW-7158 in overactive bladder may be due to the activation of A-type K(+) channels...
Investigational
Matched Description: … KW-7158 is a tricyclic compound with a non-cholingergic mechanism of action for the treatment of "urinary ... The therapeutic effects of KW-7158 in overactive bladder may be due to the activation of A-type K(+) …
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
IDD-3
IDD-3 is a therapeutic specific immunostimulant developed by IDM Pharma in partnership with sanofi-aventis. It consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. It includes Dendritophages that are dendritic cells, a type of specialized immune cells derived from the patient's own white blood cells.
Investigational
Matched Description: … IDD-3 is a therapeutic specific immunostimulant developed by IDM Pharma in partnership with sanofi-aventis ... It includes Dendritophages that are dendritic cells, a type of specialized immune cells derived from …
Thienylfentanyl
Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the Federal Analog Act scheduled drugs based on structural similarity rather than scheduling drugs individually. Thienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted for phenethyl bromide.
Illicit
Matched Description: … Thienylfentanyl is a fentanyl analog analgesic that was sold on the black market in the 1980s until the ... Thienylfentanyl has a similar synthesis pathway to fentanyl except 2-(2-bromoethyl)thiophene is substituted …
OTL-201
OTL-201 is an investigational hematopoietic stem cell (HSC) gene therapy being developed by Orchard Therapeutics for the treatment of mucopolysaccharidosis type IIIA (MPS-IIIA). It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase (SGSH) gene into autologous CD34+ hematopoietic stem cells.
Investigational
Matched Description: … It consists of a lentiviral vector to insert a functional copy of the human N-Sulfoglucosamine Sulfohydrolase …
Thioproperazine
Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and...
Experimental
Matched Description: … Thioproperazine is a potent neuroleptic with antipsychotic properties. ... Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight …
V1003
V1003 is an intranasal formulation of buprenorphine, an opiate analgesic, for the management of post-operative pain in hospital and home settings. Buprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a convenient alternative to other treatments, allowing patients to manage their post-operative pain both prior...
Investigational
Matched Description: … Buprenorphine is a well-known analgesic and the intranasal formulation has the potential to provide a …
DG051
DG051 is a novel small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), the protein made by one of the genes in the leukotriene pathway that has been shown to link to risk of heart attack. DG051 is designed to decrease risk of heart attack by decreasing the production of leukotriene B4...
Investigational
Matched Description: … DG051 is a novel small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), the protein made by one ... by decreasing the production of leukotriene B4 (LTB4), an end product of the leukotriene pathway and a …
3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole
3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole is a solid. This compound belongs to the phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. 3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole is known to target genome polyprotein.
Experimental
Matched Description: … 3-Methyl-5-(7-{4-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]phenoxy}heptyl)-1,2-oxazole is a solid. ... These are aromatic compounds containing an ether group substituted with a benzene ring. 3-Methyl-5-(7 …
Guvacine
Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that...
Experimental
Matched Description: … Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). ... Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant …
BacTRL-spike
BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled Trial (NCT04334980) to...
Investigational
Matched Description: … BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum ... As of June, 2020, the company is pursuing a Phase 1, Randomized, Observer-Blind, Placebo-Controlled …
FAV-201
FAV-201 is a patient-specific immunotherapy for the treatment of T-cell lymphoma.
Investigational
Matched Description: … FAV-201 is a patient-specific immunotherapy for the treatment of T-cell lymphoma. …
Lexatumumab
Lexatumumab is a fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibody (mAb).
Investigational
Matched Description: … Lexatumumab is a fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibody (mAb). …
Perifosine
Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.
Investigational
Matched Description: … Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase …
Teclozan
Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections.
Experimental
Matched Description: … Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections. …
SCH-58500
SCH-58500 is a recombinant replication-deficient adenovirus vector carrying the human p53 gene.
Investigational
Matched Description: … SCH-58500 is a recombinant replication-deficient adenovirus vector carrying the human p53 gene. …
MDX-1097
MDX-1097 is a chimeric monoclonal antibody directed against the kappa myeloma antigen (KMA).
Investigational
Matched Description: … MDX-1097 is a chimeric monoclonal antibody directed against the kappa myeloma antigen (KMA). …
PT886
PT886 is a bispecific antibody against Claudin 18.2 and cluster of differentiation 47 (CD47)
Investigational
Matched Description: … PT886 is a bispecific antibody against Claudin 18.2 and cluster of differentiation 47 (CD47) …
Glisoxepide
Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide,...
Investigational
Saredutant
Saredutant (SR 48968) is a neurokinin-2 antagonist drug being developed as an antidepressant and anxiolytic by Sanofi-Aventis.
Investigational
Matched Description: … Saredutant (SR 48968) is a neurokinin-2 antagonist drug being developed as an antidepressant and anxiolytic …
XR5944
XR5944 is a DNA bis-intercalating anticancer drug. It has both intercalating and antineoplastic activities.
Investigational
Matched Description: … XR5944 is a DNA bis-intercalating anticancer drug. …
Ularitide
Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is involved in regulating blood pressure and the excretion of water and sodium from the kidneys. Urodilatin is produced in the kidney and excreted into the urine, and thus exists in low levels naturally in the...
Investigational
Matched Description: … Ularitide is a synthetic form of urodilatin, a naturally occurring human natriuretic peptide that is ... Ularitide is currently in Phase 2 development as a potential treatment for patients with acute decompensated …
Displaying drugs 10826 - 10850 of 11900 in total