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Displaying drugs 1176 - 1200 of 15670 in total

Trypsin

Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals. When converted from its zymogen trypsinogen, trypsin is available as an active peptide hydrolase (EC 3.4.21.4) form to cleave peptide chains, mainly at the carboxyl side of the amino acids lysine or arginine....
Approved
Vet approved
Matched Description: … Trypsin is a serine protease that plays an essential role in protein hydrolysis and absorption in mammals ... Trypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety ... of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Danaparoid

Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and DB09301 , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity that works by inhibiting...
Approved
Withdrawn
Matched Description: … of a mixture of glycosaminoglycans [A32565]. ... The use of Orgaran™ was discontinued in the United States however it is available in several other countries ... shortage in drug substance by the manufacturer. …

Mifamurtide

Mifamurtide is an immunomodulator with antitumor activity via activation of macrophages and monocytes. Also called L-MTP-PE, mifamurtide may be a liposomal form of of the active ingredient MTP-PE, which is a synthetic, less pyrogenic, and longer-acting derivative of muramyl dipeptide (MDP). MDP is a motif present in all gram-positive and...
Approved
Experimental
Matched Iupac: … -1-oxohexan-3-yl]oxy}propanamido]propanamido]butanamido]propanamido]ethyl phosphono}oxy)-3-(hexadecanoyloxy ... sodium (2R)-1-({2-[(2S)-2-[(4R)-4-carbamoyl-4-[(2S)-2-[(2R)-2-{[(2R,3R,4R,5R)-2-acetamido-4,5,6-trihydroxy ... )propan-2-yl hexadecanoate hydrate …
Matched Description: … MDP is a motif present in all gram-positive and gram-negative bacterial walls that is recognized by different ... Mifamurtide is marketed in Europe as Mepact for intravenous infusion. ... In a large, randomized, open-label, multicenter, phase III trial, the treatment of mifamurtide in conjunction …

Palovarotene

Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million individuals, is an exceptionally rare genetic disorder. FOP is caused by a gain-of-function mutation in the ACVR1/ALK2 gene which results in progressive heterotopic ossification, a process wherein connective tissues (e.g. skeletal muscle, ligaments, tendons) are replaced...
Approved
Investigational
Matched Iupac: … 4-[(1E)-2-{5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl}ethenyl] …
Matched Description: … Fibrodysplasia Ossificans Progressiva (FOP), with an estimated worldwide prevalence of one in 2 million ... [A244920] Palovarotene was approved for use in Canada in January 2022 for the management of heterotopic ... interest in novel treatments for this disease. …

Magnesium hydroxide

Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially...
Approved
Investigational
Matched Iupac: … magnesium(2+) dihydroxide …
Matched Description: … It can also be used topically as a deodorant or for the relief of canker sores (aphthous ulcers). ... Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable ... magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used commercially as a …
Matched Mixtures name: … NOAX 3 ... One-A-day Advance Men's ... Maalox oral suspension in sachet …
Matched Categories: … Drugs for Acid Related Disorders …

Koeleria macrantha pollen

Koeleria macrantha pollen is the pollen of the Koeleria macrantha plant. Koeleria macrantha pollen is mainly used in allergenic testing.
Approved
Matched Description: … Koeleria macrantha pollen is mainly used in allergenic testing. …

Sodium aurothiomalate

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in...
Approved
Investigational
Matched Iupac: … disodium 2-(auriosulfanyl)butanedioate …
Matched Description: … Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects ... Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold ... It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence …

Methylparaben

Methylparaben is used in allergenic testing.
Approved
Matched Description: … Methylparaben is used in allergenic testing. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Grepafloxacin

Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States.
Approved
Investigational
Withdrawn
Matched Iupac: … 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid …
Matched Description: … , and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. ... Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram …
Matched Salts cas: … 161967-81-3 …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Meprednisone

Approved
Investigational
Matched Iupac: … (1S,2R,10S,11S,13S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵ …
Matched Categories: … Corticosteroids for Systemic Use ... Corticosteroids for Systemic Use, Plain …

Terbutaline

Terbutaline was first synthesized in 1966 and described in the literature in the late 1960s and early 1970s. It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients.[A230333,L32093,L32098] Terbutaline was granted FDA approval on 25 March 1974.
Approved
Matched Iupac: … 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol …
Matched Description: … [A230328] It is a selective beta-2 adrenergic agonist used as a bronchodilator in asthmatic patients. ... Terbutaline was first synthesized in 1966[A230333] and described in the literature in the late 1960s …
Matched Categories: … Adrenergics for Systemic Use ... Adrenergic beta-2 Receptor Agonists ... Drugs for Obstructive Airway Diseases ... Selective Beta 2-adrenergic Agonists …

Ivosidenib

Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivosidenib was granted accelerated approval by the FDA...
Approved
Investigational
Matched Iupac: … (2S)-2-(2-chlorophenyl)-2-{1-[(2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidin-2-yl]-N-(5-fluoropyridin-3 …
Matched Description: … a positive opinion of ivosidenib and recommended it be granted marketing authorization for the treatment ... Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. ... [L48781] In February 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Valdecoxib

Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Approved
Investigational
Withdrawn
Matched Iupac: … 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide …
Matched Description: … ., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke …
Matched Categories: … COX-2 Inhibitors ... Selective Cyclooxygenase 2 Inhibitors (NSAIDs) …

American chestnut

American chestnut allergenic extract is used in allergenic testing.
Approved
Matched Description: … American chestnut allergenic extract is used in allergenic testing. …

Amaranthus retroflexus whole

Amaranthus retroflexus whole allergenic extract is used in allergenic testing.
Approved
Matched Description: … Amaranthus retroflexus whole allergenic extract is used in allergenic testing. …

Tyrothricin

Tyrothricin is an antibiotic peptide complex produced and extracted from the aerobic Gram-positive bacillus Brevibacillus parabrevis [L4019, L4021, A32851] which was previously categorized as Bacillus brevis and Bacillus aneurinolyticus . This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely of the six predominant tyrocidines, TrcA/A1,...
Approved
Matched Description: … does demonstrate systemic toxicity [L4019, L4021, L4022], although certain formulations that are safe for ... This complex is a mixture comprised of 60% tyrocidine cationic cyclic decapeptides (consisting largely ... /C1, and other more minor contributors) and 40% neutral linear gramicidins (where valine-gramicidin A …
Matched Categories: … Antibiotics for Topical Use …

Boric acid

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes . It...
Approved
Matched Description: … Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical ... in pharmaceutical products, cosmetics, lotions, soaps, mouthwash, toothpaste, astringents, and eyewashes ... Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Sodium borate

Approved
Experimental

Distearyldimonium

Approved
Experimental
Matched Salts cas: … 107-64-2 …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Buclizine

Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects , belonging to the piperazine derivative family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957. Following this, it was touted to be effective as an appetite stimulant in children when administered...
Approved
Matched Description: … [A178102] In addition to the above conditions, buclizine has been studied in the treatment of migraine ... in the syrup form, however, this indication has not been validated. ... attacks and in the treatment of nausea and vomiting during pregnancy. …
Matched Categories: … Antihistamines for Systemic Use …

Influenza virus type B

Approved

Arbutamine

Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Approved
Matched Iupac: … 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol …
Matched Description: … Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated ... to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in ... diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately …
Matched Salts cas: … 125251-66-3 …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Adrenergic beta-2 Receptor Agonists ... Adrenergic beta-3 Receptor Agonists …

Tezacaftor

Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Iupac: … 1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)-N-{1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan ... -2-yl)-1H-indol-5-yl}cyclopropane-1-carboxamide …
Matched Description: … the gene for the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, an ion channel ... Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class ... [A20298,A20299] As a result, CF patients produce thick, sticky mucus that clogs the ducts of organs where …
Matched Categories: … Heterocyclic Compounds, 2-Ring …

Neisseria meningitidis group y capsular oligosaccharide diphtheria crm197 protein conjugate antigen

Neisseria meningitidis group y capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a vaccine.
Approved
Matched Description: … Neisseria meningitidis group y capsular oligosaccharide diphtheria crm197 protein conjugate antigen is a …

Streptococcus pneumoniae type 15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen

Streptococcus pneumoniae type 15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 15B individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides...
Approved
Matched Description: … The saccharides in the vaccine are prepared from purified polysaccharides that are chemically activated ... Streptococcus pneumoniae type 15B capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a ... antigens of *Streptococcus pneumoniae* serotype 15B individually conjugated to the CRM197 protein, a …
Displaying drugs 1176 - 1200 of 15670 in total