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Displaying drugs 5376 - 5400 of 5601 in total
RO-6870810 is under investigation in clinical trial NCT02308761 (A Study of RO6870810/TEN-010 in Participants With Acute Myeloid Leukemia and Myelodysplastic Syndrome).
Investigational
Matched Iupac: … (6),4,7,10,12-pentaen-9-yl]-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide ... 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0^{2,6}]trideca-2
Elenbecestat is under investigation in clinical trial NCT02956486 (A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Subjects With Early Alzheimer's Disease).
Investigational
Matched Iupac: … N-{3-[(4aS,5R,7aS)-2-amino-5-methyl-4H,4aH,5H,7H,7aH-furo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl}-5 ... -(difluoromethyl)pyrazine-2-carboxamide …
Investigational
Matched Iupac: … 2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoic acid …
Halofuginone is a low molecular weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progression and metastasis in mice. Collgard Biopharmaceuticals is developing halofuginone for the treatment of scleroderma and received orphan drug designation from the U.S....
Investigational
Vet approved
Matched Synonyms: … (+/-)-trans-7-bromo-6-chloro-3-(3-(3-hydroxy-2-piperidyl)-acetonyl)-4(3H)-quinazolinone …
Matched Iupac: … 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}-3,4-dihydroquinazolin-4-one …
Matched Description: … (MMP-2) gene expression. ... weight quinazolinone alkaloid, and a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Investigational
Pegargiminase is an anticancer agent.
Investigational
Dilpacimab is under investigation in clinical trial NCT03368859 (A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab).
Investigational
Otenabant has been investigated for the treatment of Obesity.
Investigational
Matched Iupac: … 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Lodenafil carbonate has been used in trials studying the treatment of Coronaropathy and Erectile Dysfunction.
Investigational
Matched Iupac: … bis{2-[4-(4-ethoxy-3-{1-methyl-7-oxo-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}benzenesulfonyl) …
Temafloxacin is an antibiotic agent belonging to the fluoroquinolone drug class. It was first approved for use in the U.S. market in 1992, but was withdrawn shortly due to the reports of serious adverse reactions, such as allergic reactions and hemolyric anemia, resulting in three deaths.
Withdrawn
Matched Categories: … Heterocyclic Compounds, 2-Ring …
TOP-1288 is under investigation in clinical trial NCT02888379 (Phase 2a Study to Evaluate the Safety/Tolerability and Efficacy of TOP1288 200 mg Rectal Solution Once Daily for 4 Weeks in Ulcerative Colitis).
Investigational
Matched Iupac: … -2-yl}amino)-5-ethynyl-N-{2-[2-(2-methoxyethoxy)ethoxy]ethyl}benzamide ... 3-({4-[(4-{[(5-tert-butyl-3-methanesulfonamido-2-methoxyphenyl)carbamoyl]amino}naphthalen-1-yl)oxy]pyrimidin …
Investigational
Matched Iupac: … 4-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-8-oxo-11-thia-1,3-diazatetracyclo[8.7.0.0 ... ^{2,7}.0^{12,17}]heptadeca-2(7),3,5,9,12,14,16-heptaene-9-carboxamide …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Investigational
Matched Synonyms: … Methanesulfonate-1-sec-butoxycarbonyloxymethyl-1-methyl-4-{4-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2- …
Experimental
Illicit
Matched Iupac: … (2-{2-[(4-ethoxyphenyl)methyl]-5-nitro-1H-1,3-benzodiazol-1-yl}ethyl)diethylamine …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine (PEPAP) is a synthetic analogue of meperidine. It is sold as a "synthetic heroin."
Experimental
Illicit
Matched Synonyms: … 1-(2-Phenethyl)-4-phenyl-4-acetoxypiperidine …
Matched Name: … 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine …
Matched Iupac: … 4-phenyl-1-(2-phenylethyl)piperidin-4-yl acetate …
Matched Description: … 1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine (PEPAP) is a synthetic analogue of meperidine. …
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Leuvectin (formerly known as VCL-1102) is a component of gene therapy along with cationic lipid 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE).
Investigational
Matched Synonyms: … DNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing human interleukin-2
Mgb Bp 3 is under investigation in clinical trial NCT02518607 (Safety, Blood Levels and Effects of MGB-BP-3).
Investigational
Matched Iupac: … 1-methyl-N-(1-methyl-5-{[2-(morpholin-4-yl)ethyl]carbamoyl}-1H-pyrrol-3-yl)-4-{4-[(E)-2-(quinolin-3-yl ... )ethenyl]benzamido}-1H-pyrrole-2-carboxamide …
Investigational
Matched Iupac: … -2-yl}amino)-N-(1-methylpiperidin-4-yl)benzamide ... 2-fluoro-5-methoxy-4-({4-[(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)oxy]-5-(trifluoromethyl)pyrimidin …
CPX has been used in trials studying the treatment of Cystic Fibrosis.
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Investigational
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Basic Fibroblast Growth Factor (bFGF) is a single-chain polypeptide growth factor that plays a significant role in the process of wound healing and is a potent inducer of physiologic angiogenesis. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative...
Investigational
Matched Synonyms: … FGF 2 ... Heparin-binding growth factor 2
Matched Description: … protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors …
Investigational
Matched Iupac: … 5-methyl-2-(piperazin-1-yl)benzene-1-sulfonic acid …
Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.
Investigational
Matched Iupac: … dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2( …
Matched Description: … Ruboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes …
Matched Salts cas: … 192050-59-2
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Elubrixin has been used in trials studying the treatment of Cystic Fibrosis, Colitis, Ulcerative, and Chronic Obstructive Pulmonary Disease (COPD).
Investigational
Matched Iupac: … 1-[4-chloro-2-hydroxy-3-(piperazine-1-sulfonyl)phenyl]-3-(2-chloro-3-fluorophenyl)urea …
Displaying drugs 5376 - 5400 of 5601 in total