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Displaying drugs 2801 - 2825 of 9610 in total

Elvitegravir

Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome and thereby blocks the formation of the...
Approved
Matched Description: … of the viral infection. ... On September 24, 2014, the FDA approved the single pill form of elvitegravir. ... immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Dienogest

Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not...
Approved
Matched Description: … It is a derivative of 19-nortestosterone and has antiandrogenic properties. ... , dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of ... Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Docetaxel

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of paclitaxel.[A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric...
Approved
Investigational
Matched Description: … different types of cancer, including breast, ovarian, and non-small cell lung cancer. ... Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. ... Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of …
Matched Products: … DOCETAXEL SANDOZ (R)80 MG …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Products: … KLACID (R) MR …

Rivastigmine

Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer's type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Approved
Investigational
Matched Description: … of the Alzheimer's type. ... Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia …

Brexpiprazole

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to aripiprazole, brexpiprazole has different binding affinities for dopamine and serotonin receptors. Compared...
Approved
Investigational
Matched Description: … [A182186] Currently approved for the treatment of depression, schizophrenia, and agitation associated …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Rimonabant

Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved...
Approved
Investigational
Matched Description: … Its main avenue of effect is reduction in appetite. …

Ropinirole

Ropinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first...
Approved
Investigational
Matched Description: … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing ... Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease ... In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless …

Lamotrigine

Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It...
Approved
Investigational
Matched Description: … It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. ... medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of …

Rye

Rye allergenic extract is used in allergenic testing.
Approved

Meloxicam

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and...
Approved
Vet approved
Matched Description: … effects, however, this is a topic of controversy. ... Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including ... It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract …
Matched Products: … SINDULFAN (R) TABLETAS …

Rifamycin

Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product of fermentation from the gram-positive bacterium Amycolatopsis mediterranei, also known as Streptomyces mediterranei. The parent compound of rifamycin was rifamycin B which was originally obtained as a main product in the presence...
Approved
Investigational
Matched Description: … presence of diethylbarburitic acid. ... SV there was the first antibiotic used intravenously for the treatment of tuberculosis. ... Rifamycin is the prime member of the rifamycin family which are represented by drugs that are a product …
Matched Categories: … Drugs for Treatment of Tuberculosis …

Tegaserod

Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C).[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause...
Approved
Investigational
Withdrawn
Matched Description: … have resulted in the limited reintroduction or 're-approval' of tegaserod for treatment of IBS-C specifically ... in female patients less than 65 years of age and whom are considered to be at a lower risk of a cardiovascular ... name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Lofexidine

Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Description: … non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of ... [T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more ... antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Bupropion

Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake...
Approved
Matched Description: … [A178825,A1966,A16508] A Cochrane Review of meta-analyses of available treatment modalities for smoking ... rate of hypothalamic pro-opiomelanocortin (POMC) neurons and blockade of opioid receptor-mediated POMC ... the brain involved in the regulation of food intake. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Vortioxetine

Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Matched Description: … of these receptors appear to be involved in the antidepressant effects of SRIs. ... the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an ... antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Midazolam

Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazolam is available by...
Approved
Illicit
Matched Description: … This drug is unique from others in this class due to its rapid onset of effects and short duration of ... [L45098] In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive ... [A173842] It belongs to a class of drugs called _benzodiazepines_. …

Lisinopril

Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a...
Approved
Investigational
Matched Description: … [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin ... [A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension …
Matched Products: … ลิสพริล (R) 20 มก. …

Phenobarbital

A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Categories: … combinations of barbiturates ... Metabolic Side Effects of Drugs and Substances …

Rosin

Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including printing, lead-tin industry, and food production. In the pharmaceuticals, rosin...
Approved
Matched Description: … Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. …

Quetiapine

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … QUETIAMET(R) 25 MG TABLETA RECUBIERTA …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …

Eletriptan

Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sirolimus

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … [A13448] Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR ... the Vai Atari region of Rapa Nui (Easter Island). ... lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …

Rosiglitazone

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor...
Approved
Investigational
Matched Description: … Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular ... Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with ... This is the subject of a clinical trial currently underway. …
Displaying drugs 2801 - 2825 of 9610 in total