Displaying drugs 2876 - 2900 of 9732 in total
Rimonabant
Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved...
Approved
Investigational
Matched Description: … Its main avenue of effect is reduction in appetite. …
Ropinirole
Ropinirole, also known as ReQuip, is a non-ergoline dopamine agonist used in Parkinson's disease and restless legs syndrome [FDA label], . It is manufactured by GlaxoSmithKline Pharmaceuticals. Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease. In 2005, it was the first...
Approved
Investigational
Matched Description: … In 2008, the extended-release capsules of ropinirole were approved, allowing for less frequent dosing ... Ropinirole was initially approved in 1997 by the FDA [FDA label] for the management of Parkinson's disease ... In 2005, it was the first drug approved in the US for the management of primary moderate to severe restless …
Lamotrigine
Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It...
Approved
Investigational
Matched Description: … It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. ... medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of …
Calaspargase pegol
Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparaginase treatment...
Approved
Matched Description: … a multi-agent chemotherapy regimen for the treatment of ALL [L4890]. ... This forms the basis of asparaginase treatment in ALL [A40270], [A40273], [F2432]. ... Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine …
Lonapegsomatropin
Lonapegsomatropin, also known as TransCon hGH or ACP 001, is a methoxypegylated prodrug of human growth hormone (somatropin) indicated for the treatment of children 1 year and older, weighing at least 11.5 kg, with growth failure due to insufficient growth hormone secretion.[A237605,L36380,L36405] Unlike somatropin, which requires daily dosing, lonapegsomatropin can...
Approved
Investigational
Matched Description: … Lonapegsomatropin, also known as TransCon hGH or ACP 001, is a methoxypegylated prodrug of human growth ... hormone ([somatropin]) indicated for the treatment of children 1 year and older, weighing at least 11.5 …
Tegaserod
Novartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C).[L5918,F4229] It was, however, voluntarily withdrawn from widespread use in the US market in 2007 after concerns arose over the possibility that tegaserod could potentially cause...
Approved
Investigational
Withdrawn
Matched Description: … have resulted in the limited reintroduction or 're-approval' of tegaserod for treatment of IBS-C specifically ... in female patients less than 65 years of age and whom are considered to be at a lower risk of a cardiovascular ... name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Lofexidine
Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment...
Approved
Investigational
Matched Description: … non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of ... [T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more ... antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Bupropion
Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake...
Approved
Matched Description: … [A178825,A1966,A16508] A Cochrane Review of meta-analyses of available treatment modalities for smoking ... rate of hypothalamic pro-opiomelanocortin (POMC) neurons and blockade of opioid receptor-mediated POMC ... the brain involved in the regulation of food intake. …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …
Vortioxetine
Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin receptors and inhibits the reuptake...
Approved
Investigational
Matched Description: … of these receptors appear to be involved in the antidepressant effects of SRIs. ... the serotonin transporter, as a partial agonist of the 5-HT1B receptor, an agonist of 5-HT1A, and an ... antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Nalmefene
Nalmefene, a 6-methylene analogue of naltrexone, is an opioid receptor antagonist. It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor. In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence. Nalmefene...
Approved
Investigational
Withdrawn
Matched Iupac: … cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18 …
Matched Description: … Nalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist. ... [L40684] The nasal spray formulation of nalmefene was approved by the FDA in May 2023.[L46511] ... It is used for complete or partial reversal of opioid drug effects, including respiratory depression, …
Matched Description: … Nalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist. ... [L40684] The nasal spray formulation of nalmefene was approved by the FDA in May 2023.[L46511] ... It is used for complete or partial reversal of opioid drug effects, including respiratory depression, …
Copper
Copper is a transition metal and a trace element in the body. It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and superoxide dismutase [FDA Label]. Copper is commonly used in contraceptive intrauterine devices (IUD) .
Approved
Investigational
Matched Description: … It is important to the function of many enzymes including cytochrome c oxidase, monoamine oxidase and …
Matched Mixtures name: … Formula R Mineral Supplement …
Matched Mixtures name: … Formula R Mineral Supplement …
Lisinopril
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and captopril are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system.[A184781,A184808,A184817] ACEIs are commonly used as a...
Approved
Investigational
Matched Description: … [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin ... [A184781,A184808,A184817] ACEIs are commonly used as a first line therapy in the treatment of hypertension …
Matched Products: … ลิสพริล (R) 20 มก. …
Matched Products: … ลิสพริล (R) 20 มก. …
Phenobarbital
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Approved
Investigational
Matched Categories: … combinations of barbiturates ... Metabolic Side Effects of Drugs and Substances …
Enzacamene
Commonly known as 4-methylbenzylidene-camphor (4-MBC), enzacamene is a camphor derivative and an organic chemical UV-B filter. It is used in cosmetic products such as sunscreen to provide skin protection against UV rays. While its effects on the human reproductive system as an endocrine disruptor are being investigated, its use in...
Approved
Matched Mixtures name: … Glamtox SPF 18 …
Quetiapine
Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … QUETIAMET(R) 25 MG TABLETA RECUBIERTA …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Products: … QUETIAMET(R) 25 MG TABLETA RECUBIERTA …
Rosin
Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. It is prepared from heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin is used in various commercial and industrial applications, including printing, lead-tin industry, and food production. In the pharmaceuticals, rosin...
Approved
Matched Description: … Rosin is a solid form of resin obtained from pines and other plants, mostly conifers. …
Tenofovir alafenamide
Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections …
Eletriptan
Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Approved
Investigational
Matched Description: … Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Sirolimus
Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria Streptomyces hygroscopicus, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor...
Approved
Investigational
Matched Description: … [A13448] Its primary mechanism of action is the inhibition of the mammalian target of rapamycin (mTOR ... the Vai Atari region of Rapa Nui (Easter Island). ... lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …
Matched Categories: … Mammalian target of rapamycin (mTOR) kinase inhibitors …
Risankizumab
Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease.[L39885,L44191,L44231] Risankizumab...
Approved
Investigational
Thioridazine
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed,...
Approved
Withdrawn
Matched Description: … Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal ... control of severely disturbed or agitated behavior. ... A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Glecaprevir
Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with DB13878, glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic barrier against resistance...
Approved
Investigational
Matched Description: … treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [FDA Label]. ... It demonstrates a high genetic barrier against resistance mutations of the virus. ... The combinations of amino acid substitutions at NS3 position Y65H and D/Q168 also results in greater …
Matched Categories: … Antivirals for treatment of HCV infections …
Matched Categories: … Antivirals for treatment of HCV infections …
Paliperidone
Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin...
Approved
Matched Description: … the other effects of the drug. ... Paliperidone is the primary active metabolite of risperidone. ... The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …
Fidanacogene elaparvovec
Fidanacogene elaparvovec is a liver-specific adeno-associated virus (AAV) vector containing a codon-optimized human coagulation FIX gene that was investigated as a potential treatment for hemophilia B. Hemophilia B is a rare X-linked genetic disorder characterized by abnormal coagulation due to dysfunctional coagulation factor IX with a male incidence estimated to...
Approved
Investigational
Matched Description: … Current available treatments include substitution therapy involving the intravenous administration of ... [A32552] Disease severity is linked to the level of factor IX activity in the blood plasma, ranging from ... fidanacogene elaparvovec was approved by Health Canada under the brand name BEQVEZ for the treatment of …
Displaying drugs 2876 - 2900 of 9732 in total