Displaying drugs 401 - 425 of 780 in total
Loncastuximab tesirine
Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. Prognosis is poor and more effective therapies are needed to treat relapsed/refractory cases and improve survival. On April 23 2021, the Food and Drug Administration granted accelerated...
Approved
Investigational
Matched Description: … accelerated approval for relapsed or refractory B-cell lymphoma is based on promising results from the LOTIS-2 …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Basiliximab
A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell...
Approved
Investigational
Matched Description: … that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 ... receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. …
Matched Categories: … Interleukin-2 Receptor Antagonist ... Interleukin-2 Receptor Blocking Antibody ... Interleukin 2 Receptor-directed Antibody Interactions …
Matched Categories: … Interleukin-2 Receptor Antagonist ... Interleukin-2 Receptor Blocking Antibody ... Interleukin 2 Receptor-directed Antibody Interactions …
Atorvastatin
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Iupac: … (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic …
Belimumab
Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A251495, L42705] By binding to...
Approved
Hydrocortisone butyrate
Approved
Vet approved
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H …
Hydrocortisone cypionate
Approved
Investigational
Vet approved
Matched Iupac: … ,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl 3-cyclopentylpropanoate ... 2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H …
Hydrocortisone phosphate
Approved
Vet approved
Matched Iupac: … ,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}phosphonic acid ... {2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H …
Hydrocortisone probutate
Approved
Vet approved
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-9a,11a-dimethyl-7-oxo-1-[2-(propanoyloxy)acetyl]-1H,2H,3H,3aH …
Hydrocortisone valerate
Approved
Vet approved
Matched Iupac: … (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H …
Ustekinumab
Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic disease-modifying anti-rheumatic drug (bDMARDs) that...
Approved
Investigational
Duvelisib
Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed that this agent is...
Approved
Investigational
Matched Iupac: … 8-chloro-2-phenyl-3-[(1S)-1-[(9H-purin-6-yl)amino]ethyl]-1,2-dihydroisoquinolin-1-one …
Matched Description: … Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Phosphatidylinositol-3-kinase (Pi3K) inhibitors ... Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
Matched Description: … Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases …
Matched Categories: … Heterocyclic Compounds, 2-Ring ... Phosphatidylinositol-3-kinase (Pi3K) inhibitors ... Phosphatidylinositol 3-Kinases, antagonists & inhibitors …
Zanubrutinib
Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival. BTK...
Approved
Investigational
Matched Iupac: … (7S)-2-(4-phenoxyphenyl)-7-[1-(prop-2-enoyl)piperidin-4-yl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Fluocinonide
A topical glucocorticoid used in the treatment of eczema.
Approved
Investigational
Matched Iupac: … [10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-8-yl]-2-oxoethyl acetate ... 2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo …
Ibalizumab
Ibalizumab (also known as ibalizumab-uiyk and formerly known as TNX-355) is a monoclonal antibody that binds to CD4 receptors on the surface of CD4-positive cells, preventing HIV particle entry into the lymphocytes. It is an advanced and current antibody in development for the treatment of HIV/AIDS. It has been developed...
Approved
Investigational
Etrasimod
Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Matched Iupac: … 2-[(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1H,2H,3H,4H-cyclopenta[b]indol-3-yl]acetic …
Matched Description: … /sub> and S1P3 receptors. ... [A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs ... S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2< …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Description: … /sub> and S1P3 receptors. ... [A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs ... S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2< …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Omidubicel
Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood used as an allogeneic stem cell donor source. Umbilical blood cord cells are expanded ex-vivo and nicotinamide (a form of vitamin B3) is used as an active agent in the culture system to inhibit the differentiation and...
Approved
Investigational
Matched Description: … whom a related or unrelated donor cannot be found due to the requirement of high-grade human leukocyte antigen …
Influenza A virus A/Texas/50/2012 (H3N2) recombinant hemagglutinin antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Synonyms: … Influenza A virus vaccine, A-Texas-50-2012 X-223A (H3N2), Inactivated …
Matched Name: … Influenza A virus A/Texas/50/2012 (H3N2) recombinant hemagglutinin antigen …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Name: … Influenza A virus A/Texas/50/2012 (H3N2) recombinant hemagglutinin antigen …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Influenza A virus A/Brisbane/59/2007(H1N1) hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/Brisbane/59/2007(H1N1) hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Categories: … Inactivated Influenza A Virus Vaccine …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Categories: … Inactivated Influenza A Virus Vaccine …
Influenza B virus B/Brisbane/46/2015 antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Brisbane/46/2015 antigen (propiolactone inactivated) …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Influenza B virus B/Maryland/15/2016 antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza B virus B/Maryland/15/2016 antigen (propiolactone inactivated) …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Influenza A virus A/Uruguay/716/2007(H3N2) hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/Uruguay/716/2007(H3N2) hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Influenza A virus A/Uruguay/716/2007(H3N2) live (attenuated) antigen
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Synonyms: … Influenza a Virus H3N2 Live Antigen, A ... Influenza a Virus A/uruguay/716/2007(H3N2) Live(attenuated) Antigen …
Matched Name: … Influenza A virus A/Uruguay/716/2007(H3N2) live (attenuated) antigen …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Name: … Influenza A virus A/Uruguay/716/2007(H3N2) live (attenuated) antigen …
Matched Description: … , or inactivated, through exposure to heat or chemicals such as formaldehyde 3. ... parts of the virus) which stimulates an immunological defence against future exposure to the virus, or "antigen ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen
Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 7F individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides...
Approved
Matched Synonyms: … Streptococcus pneumoniae serotype 7F capsular antigen diphtheria CRM197 protein conjugate vaccine …
Matched Name: … Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Matched Name: … Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 7F capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen
Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 19A individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). The saccharides...
Approved
Matched Synonyms: … Streptococcus pneumoniae serotype 19A capsular antigen diphtheria CRM197 protein conjugate vaccine …
Matched Name: … Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Matched Name: … Streptococcus pneumoniae type 19A capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 19a capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen
Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine that contains saccharides of the capsular antigens of Streptococcus pneumoniae serotype 22F individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of Corynebacterium diphtheriae strain C7 (β197). It is...
Approved
Matched Synonyms: … Streptococcus pneumoniae serotype 22F capsular antigen diphtheria CRM197 protein conjugate vaccine …
Matched Name: … Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Matched Name: … Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen …
Matched Description: … diphtheriae* strain C7 (β197). ... Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen ... conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium …
Matched Categories: … Inactivated Pneumococcal Vaccine …
Displaying drugs 401 - 425 of 780 in total