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Displaying drugs 401 - 425 of 2672 in total
Anakinra
Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta. Anakinra is...
Approved
Investigational
Matched Description: … ] Anakinra is indicated for the management of rheumatoid arthritis (RA) in patients 18 years of age or ... older who have failed one or more disease-modifying antirheumatic drugs (DMARDs), as well as the treatment …
Olutasidenib
Olutasidenib (FT-2102) is a selective and potent isocitrate dehydrogenase-1 (IDH1) inhibitor approved by the FDA in December 2022.[L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML) in patients with a susceptible IDH1 mutation as determined by an FDA-approved test. IDH1 mutations are common in...
Approved
Investigational
Matched Description: … [L44256,L44261] It is indicated for the treatment of relapsed or refractory acute myeloid leukemia (AML ... Other IDH1 inhibitors, such as [ivosidenib], have also been approved for the treatment of relapsed or …
Amivantamab
Amivantamab, also known as JNJ-61186372, is an anti-EGFR-MET bispecific antibody, derived from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose...
Approved
Investigational
Matched Description: … from Chinese hamster ovary cells, approved for the treatment of adult patients with locally advanced or ... ) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or ... [A235103,A235118] Amivantamab was found to be more effective than the EGFR inhibitor [erlotinib] or the …
Tretinoin
Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A (retinol). It is an oxidation product in the physiological pathway of vitamin A metabolism. In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. Tretinoin exhibits anti-inflammatory, antineoplastic, antioxidant,...
Approved
Investigational
Nutraceutical
Matched Mixtures name: … FOLISTER COMPLEX HAIR LOTION (R) ... FOLISTER COMPLEX HAIR LOTION (R) …
Matched Products: … RETIGEL(R) 0.05% GEL ... RETICREM(R) CREMA 0.05% …
Matched Products: … RETIGEL(R) 0.05% GEL ... RETICREM(R) CREMA 0.05% …
Agrostis gigantea pollen
Agrostis gigantea pollen is the pollen of the Agrostis gigantea plant. Agrostis gigantea pollen is mainly used in allergenic testing.
Approved
Matched Mixtures name: … K-O-R-T Standardized Grass Pollen Mix ... K-O-R-T Standardized Grass Pollen Mix ... Allergenic Extracts, K-O-R-T Grass Mixture …
Rattus norvegicus skin
Rattus norvegicus skin or pelt is used in allergenic testing.
Approved
Matched Description: … Rattus norvegicus skin or pelt is used in allergenic testing. …
Dapagliflozin
Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron...
Approved
Matched Description: … or other oral hypoglycemic agents. ... [A6757] Dapagliflozin has been investigated either as monotherapy or as an adjunct treatment with insulin …
Hyaluronidase (human recombinant)
A purified preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase (PH20). Hyaluronidase is an enzyme used to improve the absorption and dispersion of...
Approved
Investigational
NADH
NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by...
Approved
Nutraceutical
Levomenthol
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. (-)-Menthol is the naturally-occurring and main form of menthol, and is assigned the (1R,2S,5R) configuration. Menthol mediates anesthetic properties and...
Approved
Matched Description: … Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils ... Forming clear or white waxy, crystalline substance, menthol is typically solid at room temperature. ( …
Matched Mixtures name: … MENTOLCLARIDERM (R) ... FRICSOL (R) LINEMENTO ... CHAP ICE (R) MEDICATED …
Matched Mixtures name: … MENTOLCLARIDERM (R) ... FRICSOL (R) LINEMENTO ... CHAP ICE (R) MEDICATED …
Tramadol
Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered...
Approved
Investigational
Matched Description: … If used in higher doses, or with other opioids, there is a dose-related risk of overdose, respiratory …
Matched Products: … ADOLONTA (R) CAPSULAS …
Matched Products: … ADOLONTA (R) CAPSULAS …
Dibotermin alfa
Dibotermin alfa is a recombinant human bone morphogenetic protein-2 (rhBMP-2) derived from a recombinant Chinese Hamster Ovary (CHO) cell line [FDA Label]. It is implanted in patients undergoing bone surgeries or those with fractures. BMPs are subfamily of the transforming growth factor-β (TGF-β) superfamily that have different actions on the...
Approved
Investigational
Matched Description: … It is implanted in patients undergoing bone surgeries or those with fractures. ... patients with an open tibial fracture, administration of dibotermin alfa resulted in faster fracture- or …
Elosulfase alfa
Elosulfase alfa is a synthetic version of the enzyme N-acetylgalactosamine-6-sulfatase. It was approved by the FDA in 2014 for the treatment of Morquio syndrome. Elosulfase alfa was developed by BioMarin Pharmaceutical Inc. and is marketed under the brand Vimizim™. The recommended dose is 2 mg per kg given intravenously over...
Approved
Investigational
Silodosin
Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α1A subtype accounts for approximately 75% of α1-adrenoceptors in the prostate. Silodosin was first approved by...
Approved
Edaravone
Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. It has three tautomers. Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and cerebral ischemia.[A19140,L44007,A254257]
The intravenous formulation of edaravone was first approved in Japan in...
Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …
Fecal microbiota
Fecal microbiota, given either as a rectal transplant or in an oral formulation of live spores, is an FDA-approved option to prevent the recurrence of Clostridioides difficile infection (CDI) in patients given an antibacterial treatment for recurrent CDI.[A259182,L46217,L46222] Although the incidence of CDI has declined and the number of cases...
Approved
Investigational
Matched Description: … Fecal microbiota, given either as a rectal transplant or in an oral formulation of live spores, is an …
Dabigatran etexilate
Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor dabigatran.[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. In contrast to warfarin, because its anticoagulant effects...
Approved
Puccinia striiformis var. striiformis
Puccinia striiformis var. striiformis is a fungus which can provoke allergic reactions. Puccinia striiformis var. striiformis extract is used in allergenic testing.
Approved
Everolimus
Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and...
Approved
Cefamandole
Cefamandole is also known as cephamandole. It is a parenterally administered broad-spectrum cephalosporin antibiotic. It is generally formulated as a formate ester, cefamandole nafate. It is no longer marketed in the United States.
Approved
Experimental
Matched Synonyms: … (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0 …
Platanus racemosa pollen
Platanus racemosa pollen is the pollen of the Platanus racemosa plant. Platanus racemosa pollen is mainly used in allergenic testing.
Approved
Alnus rhombifolia pollen
Alnus rhombifolia pollen is the pollen of the Alnus rhombifolia plant. Alnus rhombifolia pollen is mainly used in allergenic testing.
Approved
Interferon beta-1a
Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta.
Approved
Investigational
Efbemalenograstim alfa
Efbemalenograstim alfa is a long-acting recombinant fusion protein of granulocyte-colony stimulating factor (G-CSF) due to the addition of the Fc portion of human IgG2, allowing for once-per-cycle administration.[L48852,A262167] As endogenous G-CSF mediates the differentiation of hematopoietic stem cells into granulocytes and eventually neutrophils, the administration of recombinant G-CSF like efbemalenograstim...
Approved
Displaying drugs 401 - 425 of 2672 in total