Cefamandole is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. Cefamandole is also known as cephamandole.
- Mechanism
- Curator reviewed
Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.
- Primary indication
- For the treatment of serious infections caused by susceptible strains of microorganisms.Curator reviewed · 4 structured indications
- Formula / weight
- C18H18N6O5S2 · 462.503 g/mol (avg)
- Also known as
- 5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-((HYDROXYPHENYLACETYL)AMINO)-3-(((1-METHYL-1H-TETRAZOL-5-YL)THIO)METHYL)-8-OXO-, (6R-(6.ALPHA.,7.BETA.(R*)))- · 7-D-MANDELAMIDO-3-(((1-METHYL-1H-TETRAZOL-5-YL)THIO)METHYL)-3-CEPHEM-4-CARBOXYLIC ACID · Cefadole · Cephadole · Cephamandole
- Code names
- J01DC03
Resolves to
OLVCFLKTBJRLHI-AXAPSJFSSA-NSMILES[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@H]2NC(=O)[C@H](O)C1=CC=CC=C1)C(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Cefamandole, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account