Displaying drugs 4451 - 4475 of 8235 in total
DTX-101
DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector encoding the human Factor Ix gene. It was previously investigated for the treatment of hemophilia B; however, the clinical development of DTX-101 was discontinued.
Investigational
Matched Description: … It was previously investigated for the treatment of hemophilia B; however, the clinical development of ... DTX-101 is an investigational gene therapy consisting of an adeno-associated virus serotype Rh10 vector …
XL784
XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. XL784 was specifically optimized to be MMP-1 sparing, thus potentially enhancing its safety profile and enabling higher dosing compared with other previously studied...
Investigational
Matched Description: … XL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because ... Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers ... of its important role in blood vessel formation and cell proliferation. …
ARC183
ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity. The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short half-life,...
Investigational
Matched Description: … The key
advantage of ARC183 compared to other thrombin inhibitors is its rapid onset of action and short ... ARC183 is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that ... , giving it the potential to be an ideal agent for medical procedures that require rapid resolution of …
Volixibat
Volixibat, also known as SHP626 or LUM002, is an investigational drug that will potentially be used for the treatment of Non-Alcoholic Steatohepatitis (NASH). If approved for use, it will be the first available agent for the treatment of NASH.
Volixibat is a selective inhibitor of the apical sodium-dependent bile acid...
Experimental
Investigational
Matched Description: … the treatment of NASH as abnormal cholesterol metabolism and accumulation of free cholesterol in the ... protein primarily expressed by enterocytes of the ileum. ... If approved for use, it will be the first available agent for the treatment of NASH. …
Amuvatinib
Amuvatinib has been used in trials studying the treatment of Solid Tumors and Small Cell Lung Carcinoma. Amuvatinib is an oral, selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA...
Investigational
Matched Description: … Amuvatinib has been used in trials studying the treatment of Solid Tumors and Small Cell Lung Carcinoma ... selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of ... Amuvatinib also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer …
Hesperetin
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Experimental
Matched Description: … Hesperetin belongs to the flavanone class of flavonoids. ... Hesperetin, in the form of its glycoside [hesperidin], is the predominant flavonoid in lemons and oranges …
PF-05180999
PF-05180999 is under investigation in clinical trial NCT01530529 (A Study to Assess the Relative Bioavailability of a Modified-Release Formulation of PF-05180999).
Investigational
Matched Description: … a Modified-Release Formulation of PF-05180999). ... is under investigation in clinical trial NCT01530529 (A Study to Assess the Relative Bioavailability of …
D-3082-L
D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.
Investigational
Matched Description: … D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide …
LX201
LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally to the eye over the course of one year. LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) in a minimally invasive procedure. The implant is being developed clinically...
Investigational
Matched Description: … to the eye over the course of one year. ... LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally ... LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) …
Obinepitide
Obinepitide is a synthetic analogue of two natural human hormones, PYY and Pancreatic Polypeptide, which normally are released during a meal. These hormones are known to play a role in the regulation of food intake and appetite in man as satiety signal from the GI-tract to the CNS. In obinepitide,...
Investigational
Matched Description: … In obinepitide, the properties of both of these hormones have been implanted into a single molecule. ... Obinepitide is a synthetic analogue of two natural human hormones, PYY and Pancreatic Polypeptide, which ... These hormones are known to play a role in the regulation of food intake and appetite in man as satiety …
SB-559448
SB-559448 is a small-molecule drug that mimics the activity of thrombopoietin (TPO), a protein factor that promotes growth and production of blood platelets. This drug is developed by GlaxoSmithKline and used to treat Thrombocytopenia.Thrombocytopenia (decreased platelet count) is a common side effect of many chemotherapies and can lead to uncontrolled...
Investigational
Matched Description: … that promotes growth and production of blood platelets. ... SB-559448 is a small-molecule drug that mimics the activity of thrombopoietin (TPO), a protein factor ... used to treat Thrombocytopenia.Thrombocytopenia (decreased platelet count) is a common side effect of …
PH-284
PH-284 belongs to a new family of new chemical entities called vomeropherins. Vomeropherins are self-administered by the patient with a metered nasal spray, or nasal aerosol device so that they can bind to peripheral chemosensory receptors in the nasal passages. This binding produces neural impulses that are transmitted by specific...
Investigational
Matched Description: … PH-284 is under investigation by Pherin and Organon for the treatment of anorexia nervosa, and loss of ... PH-284 belongs to a new family of new chemical entities called vomeropherins. …
Betacetylmethadol
A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]
Experimental
Illicit
Matched Description: … A narcotic analgesic with a long onset and duration of action. ... It is used mainly in the treatment of narcotic dependence. [PubChem] …
(S)-acetoin
A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.
Experimental
Matched Description: … A product of fermentation. It is a component of the butanediol cycle in microorganisms. …
(R)-acetoin
A product of fermentation. It is a component of the butanediol cycle in microorganisms. In mammals it is oxidized to carbon dioxide.
Experimental
Matched Description: … A product of fermentation. It is a component of the butanediol cycle in microorganisms. …
Abacavir hydroxyacetate
Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. Prurisol has been investigated for the treatment of Plaque Psoriasis.
Investigational
Matched Description: … Prurisol has been investigated for the treatment of Plaque Psoriasis. ... Prurisol is under investigation for the treatment of Chronic Stable Plaque Psoriasis. …
BIO-11006
BIO-11006 is under investigation in clinical trial NCT03202394 (Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS).
Investigational
Matched Description: … BIO-11006 is under investigation in clinical trial NCT03202394 (Evaluation of Safety & Efficacy of BIO …
Sevuparin
Sevuparin is under investigation in clinical trial NCT03853421 (Placebo-controlled Study to Determine the Safety and Tolerability of Subcutaneous Doses of Sevuparin).
Investigational
Matched Description: … Subcutaneous Doses of Sevuparin). ... investigation in clinical trial NCT03853421 (Placebo-controlled Study to Determine the Safety and Tolerability of …
Seliforant
Seliforant is under investigation in clinical trial NCT01260753 (Proof of Activity Study of UR-63325 in Allergic Rhinitis Induced by Nasal Challenge).
Investigational
Matched Description: … Seliforant is under investigation in clinical trial NCT01260753 (Proof of Activity Study of UR-63325 …
Olaparib-bodipy FL
Olaparib-bodipy FL is under investigation in clinical trial NCT03085147 (A Dye for the Detection of Cancer of the Tongue and Mouth).
Investigational
Matched Description: … of the Tongue and Mouth). ... Olaparib-bodipy FL is under investigation in clinical trial NCT03085147 (A Dye for the Detection of Cancer …
Pexiganan
Pexiganan is under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers).
Investigational
Matched Description: … Mild Infections of Diabetic Foot Ulcers). ... under investigation in clinical trial NCT01594762 (Pexiganan Versus Placebo Control for the Treatment of …
Suzetrigine
Suzetrigine is under investigation in clinical trial NCT05558410 (Evaluation of Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty).
Investigational
Matched Description: … Suzetrigine is under investigation in clinical trial NCT05558410 (Evaluation of Efficacy and Safety of …
Licaminlimab
Licaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab Ophthalmic Suspension for the Treatment of Dry Eye Disease).
Investigational
Matched Description: … Ophthalmic Suspension for the Treatment of Dry Eye Disease). ... Licaminlimab is under investigation in clinical trial NCT05896670 (Safety and Efficacy of Licaminlimab …
Eritoran
Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Investigational
Matched Description: … Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). ... It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis. …
Amolimogene
Amolimogene is an investigational therapeutic designed to specifically augment the body's defensive response to human papillomavirus (HPV). Amolimogene was biologically engineered as a targeted therapy for the treatment of cervical dysplasia.
Investigational
Matched Description: … Amolimogene was biologically engineered as a targeted therapy for the treatment of cervical dysplasia …
Displaying drugs 4451 - 4475 of 8235 in total