Displaying drugs 551 - 575 of 9223 in total
Phoma exigua var. exigua
Phoma exigua var. exigua is a fungus which can provoke allergic reactions. Phoma exigua var. exigua extract is used in allergenic testing.
Approved
Matched Mixtures name: … Molds - Mold Mix 10 ... Molds - Mold Mix 10 ... Molds - Mold Mix 10 …
Eflornithine
Eflornithine is an irreversible ornithine decarboxylase inhibitor originally developed as a treatment for human African trypanosomiasis. Further research has also implicated ornithine decarboxylase in other conditions like facial hirsutism and cancer, especially when ornithine decarboxylase is highly upregulated in tumor cells.[A4112, A262834] Additionally, ornithine decarboxylase is activated by c-myc or...
Approved
Withdrawn
Matched Description: … in the risk of death were observed. ... and 2000, the FDA approved eflornithine under the brand names ORNIDYL and VANIQUA for the treatment of ... eflornithine again but under the brand name IWILFIN as an oral maintenance therapy to reduce the risk of …
Imipenem
Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits...
Approved
Matched Description: … Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative …
Terbinafine
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell...
Approved
Investigational
Vet approved
Matched Iupac: … [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine …
Matched Description: … inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of …
Matched Description: … inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of …
Penicillium digitatum
Penicillium digitatum allergenic extract is used in allergenic testing.
Approved
Matched Mixtures name: … Molds - Mold Mix 10 ... Molds - Mold Mix 10 ... Molds - Mold Mix 10 …
Finasteride
Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as dutasteride, which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. Finasteride is an orally active drug...
Approved
Matched Description: … Finasteride is a synthetic 4-azasteroid compound [L10565] and specific inhibitor of steroid Type II 5α-reductase ... Finasteride is an orally active drug that was first approved by the FDA in 1992 for the treatment of ... androgenic alopecia are androgen-dependent disorders that are characterized by _in situ_ high levels of …
Aflibercept
Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial ... retinopathy of prematurity in preterm infants in February 2023 and for the treatment of wet age-related ... growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin …
Mitapivat
Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells. Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy production for red...
Approved
Investigational
Matched Description: … of red blood cells. ... It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival ... Defects in the pyruvate kinase enzyme in various red blood cells disorders lead to the lack of energy …
Matched Categories: … combinations of sulfonamides …
Matched Categories: … combinations of sulfonamides …
Tetracycline
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the...
Approved
Vet approved
Withdrawn
Matched Description: … [L43942] Other formulations of tetracycline continue to be used. ... Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria ... The FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use …
Matched Categories: … combinations of tetracyclines …
Matched Categories: … combinations of tetracyclines …
Estradiol benzoate
Estradiol Benzoate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol benzoate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Description: … produced with an ester side-chain as endogenous estradiol has very low oral bioavailability on its own (2-10% ... Ester pro-drugs of estradiol are therefore considered to be bioidentical forms of estrogen [T84]. ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …
Mefenamic acid
A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.
Approved
Matched Description: … It is an inhibitor of cyclooxygenase. …
Matched Products: … ROLAN KAPSÜL, 10 ADET ... ROLADOL 50 MG KAPSUL, 10 ADET …
Matched Products: … ROLAN KAPSÜL, 10 ADET ... ROLADOL 50 MG KAPSUL, 10 ADET …
Racemethionine
A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers.
Approved
Experimental
Matched Description: … A preparation of methionine that includes a mixture of D-methionine and L-methionine isomers. …
Matched Mixtures name: … BRAUN 10% ... BRAUN 10% ... AMINOPLASMAL® 10% E …
Matched Mixtures name: … BRAUN 10% ... BRAUN 10% ... AMINOPLASMAL® 10% E …
Abemaciclib
Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for...
Approved
Investigational
Matched Description: … ) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity ... Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6 ... On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for …
Omaveloxolone
Omaveloxolone (RTA-408) is a semisynthetic oleanane triterpenoid with antioxidant and anti-inflammatory properties.[A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor that mitigates oxidative stress. In patients with Friedreich's ataxia, a genetic disease involving mitochondrial dysfunction, the Nrf2 pathway is impaired, and Nrf2 activity...
Approved
Investigational
Matched Description: … group of patients. ... [L45424] The use of omaveloxolone for the treatment of conditions involving mitochondrial dysfunction ... [A257534,A257539] Omaveloxolone acts as an activator of nuclear factor (erythroid-derived 2)-like 2 ( …
Crizotinib
Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion protein, crizotinib offers...
Approved
Investigational
Matched Description: … Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase ... fusion protein, crizotinib offers robust effectiveness in treating NSCLC in patients with this type of ... Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic …
Sotagliflozin
Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar...
Approved
Investigational
Matched Description: … ] and [dapagliflozin], but its potency in inhibiting SGLT1 is >10-fold higher than its predecessors. ... Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind,[A244499] which is approved ... [L39739] On March 22, 2022, the marketing authorization of sotagliflozin for the treatment of type 1 …
Ubrogepant
Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor...
Approved
Investigational
Matched Description: … [A189207] Ubrogepant was approved by Health Canada on November 10, 2022. ... advance in migraine headache treatment and may become the new standard of therapy in the treatment of ... Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. …
Tiagabine
Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Approved
Investigational
Matched Iupac: … (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid …
Fenofibric acid
Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L12855] Due to its high hydrophilicity and poor absorption profile, prodrug ,fenofibrate, and other conjugated compounds...
Approved
Matched Description: … hydrophilicity and poor absorption profile,[A32038] prodrug ,[fenofibrate], and other conjugated compounds of …
Matched Mixtures name: … FENOVAS®10 MG ... FENOVAS®10 MG …
Matched Mixtures name: … FENOVAS®10 MG ... FENOVAS®10 MG …
Japanese Encephalitis Vaccine, Inactivated, Adsorbed
Approved
Investigational
Asparagine
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from aspartic acid and ammonia by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Approved
Investigational
Nutraceutical
Matched Description: … A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain …
Matched Mixtures name: … AMINOPLASMAL-10% E INFUSION ... AMINOPLASMAL HEPA 10%-500ML GLASS BOTTLE …
Matched Mixtures name: … AMINOPLASMAL-10% E INFUSION ... AMINOPLASMAL HEPA 10%-500ML GLASS BOTTLE …
Bromocriptine
Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as the treatment of acromegaly. Bromocriptine has been...
Approved
Investigational
Withdrawn
Matched Iupac: … (4R,7R)-10-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo …
Matched Description: … Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as ... In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological ... well as the treatment of acromegaly. …
Matched Description: … Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as ... In 1995, the FDA withdrew the approval of bromocriptine mesylate for the prevention of physiological ... well as the treatment of acromegaly. …
Chlorquinaldol
Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan. It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the European Medicines Agency as a combination tablet with promestriene for the treatment...
Approved
Matched Description: … approved by the European Medicines Agency as a combination tablet with promestriene for the treatment of …
Matched Mixtures name: … IMPETEX %0.1 + %1 KREM, 10 G ... NERISONA-C %0,1 + %1 KREM, 10 GR …
Matched Mixtures name: … IMPETEX %0.1 + %1 KREM, 10 G ... NERISONA-C %0,1 + %1 KREM, 10 GR …
Aclidinium
Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Description: … Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …
Polidocanol
Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural...
Approved
Matched Description: … (n) of approximately 9 and a mean molecular weight of approximately 600. ... The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization …
Matched Mixtures name: … KORTOS 27 MG/5 MG SUPOZİTUVAR, 10 ADET ... DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 10 G …
Matched Mixtures name: … KORTOS 27 MG/5 MG SUPOZİTUVAR, 10 ADET ... DENTINOX 3.4 MG/G + 3.2 MG/G + 150 MG/G JEL, 10 G …
Displaying drugs 551 - 575 of 9223 in total