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Displaying drugs 6076 - 6100 of 10840 in total

Efmarodocokin alfa

Efmarodocokin alfa is under investigation in clinical trial NCT04386616 (A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia).
Investigational
Matched Synonyms: … HUMAN INTERLEUKIN 22 (1-146), FUSED TO HUMAN IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 4 (CH1(97-98), H(S10 ... INTERLEUKIN 22 (HUMAN (MATURE)) FUSION PROTEIN WITH IMMUNOGLOBULIN G4 (SYNTHETIC HUMAN .GAMMA.4-CHAIN …

Perenostobart

Perenostobart is an alpha-CD39 IgG4 monoclonal antibody.
Investigational

2-Methylpentane-1,2,4-Triol

Experimental
Matched Iupac: … (2S,4S)-2-methylpentane-1,2,4-triol …

Rhamnose

A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides. [PubChem]
Experimental
Matched Iupac: … (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal …

Isoglutamine

Experimental
Matched Iupac: … (4S)-4-amino-4-carbamoylbutanoic acid …

3-deoxy-D-arabino-hexonic acid

Experimental
Matched Iupac: … (2S,4S,5R)-2,4,5,6-tetrahydroxyhexanoic acid …

Levoglucose

Levoglucose has been used in trials studying the diagnostic of Bowel Cleansing Prior to Colonoscopy.
Investigational
Matched Iupac: … (2S,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanal …

Ibudilast

Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411...
Investigational
Matched Categories: … Phosphodiesterase 5 Inhibitors …

K-777

Investigational
Matched Synonyms: … 1-piperazinecarboxamide, 4-methyl-n-((1s)-2-oxo-2-(((1s)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen ... 4-methylpiperazine-1-carboxylic acid [1-(3-benzenesufonyl-1-phenethylallyl-carbamoyl)-2-phenylethyl] ... 1-piperazinecarboxamide, 4-methyl-n-((1s)-2-oxo-2-(((1s)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propenyl …
Matched Iupac: … (2S)-N-[(1E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]-2-{[(E)-4-methylpiperazine-1-carbonyl]amino …

[3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid

Experimental
Matched Name: … [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid …
Matched Iupac: … 2-[3,5-dibromo-4-(4-hydroxy-3-{hydroxy[(2-phenylethyl)amino]methyl}phenoxy)phenyl]ethane-1,1-diol …

8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine

Experimental
Matched Name: … 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine …
Matched Iupac: … 8-[(2-chloro-3,4,5-trimethoxyphenyl)methyl]-2-fluoro-9-(pent-4-yn-1-yl)-9H-purin-6-amine …

4-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide

Experimental
Matched Name: … 4-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide …
Matched Iupac: … 4-bromo-N'-[(E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide …

4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid

Experimental
Matched Name: … 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid …
Matched Iupac: … 4-{[(2-chloro-4,5-difluorobenzoyl)carbamoyl]amino}-3-(trifluoromethoxy)benzoic acid …

Apitegromab

Apitegromab is under investigation in clinical trial NCT03921528 (An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy).
Investigational
Matched Synonyms: … g4 (234-proline), anti-(human progrowth differentiation factor 8) (human monoclonal srk-015 .gamma.4- …

Ibutamoren

Investigational

Epigallocatechin gallate

Epigallocatechin gallate has been investigated for the treatment of Hypertension and Diabetic Nephropathy.
Investigational

6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine

Experimental
Matched Name: … 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine …
Matched Iupac: … 6-[(3S)-3-benzylpiperazin-1-yl]-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine …

Tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate

Experimental
Matched Name: … Tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate …
Matched Iupac: … potassium (1R)-4-{[1,1'-biphenyl]-4-yl}-1-[bis(potassiooxy)phosphoryl]butane-1-sulfonate …

Morniflumate

Morniflumate is a non-steroidal anti-inflammatory drug with antipyretic properties. It is the morpholinoethyl ester of niflumic acid . In one study, post morniflumate ingestion, physical examination and clinical symptoms of those with bronchitis showed improvement .
Experimental
Matched Iupac: … 2-(morpholin-4-yl)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylate …

Redaporfin

Investigational
Matched Categories: … Heterocyclic Compounds with 4 or More Rings …

Bitolterol

Bitolterol mesylate was used to treat bronchospasms in asthma and COPD. It is a beta-2-adrenergic receptor agonist. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001.
Withdrawn
Matched Synonyms: … bis(4-methylbenzoic acid) 4-[2-(tert-butylamino)-1-hydroxyethyl]-1,2-phenylene ester ... 4-(2-(tert-butylamino)-1-hydroxyethyl)-o-phenylene di-p-toluate ... 4-[2-(tert-butylamino)-1-hydroxyethyl]-o-phenylene di-p-toluate …
Matched Iupac: … 5-[2-(tert-butylamino)-1-hydroxyethyl]-2-(4-methylbenzoyloxy)phenyl 4-methylbenzoate …

Selisistat

Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53 acetylation in response to DNA damaging agents.
Experimental

Acetyldigoxin

Experimental
Matched Iupac: … -2,15-dimethyl-14-(5-oxo-2,5-dihydrofuran-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-yl]oxy ... (2R,3R,4S,6S)-6-{[(2R,3S,4S,6S)-6-{[(2R,3S,4S,6R)-6-{[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-11,16-dihydroxy ... }-4-hydroxy-2-methyloxan-3-yl]oxy}-4-hydroxy-2-methyloxan-3-yl]oxy}-3-hydroxy-2-methyloxan-4-yl acetate …

IDD552

Experimental
Matched Iupac: … 2-(5-fluoro-2-{[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]carbamoyl}phenoxy)acetic acid …

MLN576

XR11576 (MLN576) is a novel monophenazine with a mechanism of action that includes interaction with both topoisomerase (Topo) I and II.
Investigational
Displaying drugs 6076 - 6100 of 10840 in total