Displaying drugs 601 - 625 of 2055 in total
Edaravone
Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. It has three tautomers. Edaravone works to scavenge reactive oxygen species, which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and cerebral ischemia.[A19140,L44007,A254257]
The intravenous formulation of edaravone was first approved in Japan in...
Approved
Investigational
Matched Synonyms: … Phenyl methyl pyrazolone ... 3-methyl-1-phenyl-5-pyrazolone ... 3-methyl-1-phenylpyrazol-5-one …
Matched Iupac: … 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one …
Matched Description: … Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. ... , which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and ... [L44007] It was later approved for the treatment of amyotrophic lateral sclerosis (ALS) in Japan and …
Matched Iupac: … 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one …
Matched Description: … Edaravone is a free radical scavenger and neuroprotective agent with antioxidant properties. ... , which have been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and ... [L44007] It was later approved for the treatment of amyotrophic lateral sclerosis (ALS) in Japan and …
SR-9009
SR-9009 is a REV-ERB agonist. SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues .
Experimental
Matched Synonyms: … 1-Pyrrolidinecarboxylic acid, 3-((((4-chlorophenyl)methyl)((5-nitro-2-thienyl)methyl)amino)methyl)-, …
Matched Iupac: … ethyl 3-({[(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amino}methyl)pyrrolidine-1-carboxylate …
Matched Description: … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent ... cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628 …
Matched Iupac: … ethyl 3-({[(4-chlorophenyl)methyl][(5-nitrothiophen-2-yl)methyl]amino}methyl)pyrrolidine-1-carboxylate …
Matched Description: … SR-9011 has been demonstrated that it is specifically lethal to cancer cells and oncogene-induced senescent ... cells, including melanocytic naevi, and has no effect on the viability of normal cells or tissues [A32628 …
alpha-L-methyl-fucose
Experimental
Matched Synonyms: … α-L-Methyl-Fucose ... alpha-L-1-Methyl-fucose ... Methyl alpha-L-fucopyranoside …
Matched Name: … alpha-L-methyl-fucose …
Matched Name: … alpha-L-methyl-fucose …
Sebetralstat
Investigational
Matched Synonyms: … 1(2H)-pyridinyl)methyl]phenyl]methyl]- ... methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide ... }methyl)-1H-pyrazol-4-carboxamide …
Matched Iupac: … N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxo-1,2-dihydropyridin-1-yl)methyl ... ]phenyl}methyl)-1H-pyrazole-4-carboxamide …
Matched Iupac: … N-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxo-1,2-dihydropyridin-1-yl)methyl ... ]phenyl}methyl)-1H-pyrazole-4-carboxamide …
7-methyl-GpppA
Experimental
Matched Name: … 7-methyl-GpppA …
Matched Iupac: … )-3,4-dihydroxyoxolan-2-yl]-7-methyl-6-oxo-6,7-dihydro-3H-9lambda5-purin-9-ylium ... dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl …
Matched Iupac: … )-3,4-dihydroxyoxolan-2-yl]-7-methyl-6-oxo-6,7-dihydro-3H-9lambda5-purin-9-ylium ... dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl …
Methyl Methylsulfinylmethyl Sulfide
Experimental
Matched Name: … Methyl Methylsulfinylmethyl Sulfide …
Flurbiprofen Methyl Ester
Experimental
Matched Name: … Flurbiprofen Methyl Ester …
Matched Iupac: … methyl (2S)-2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoate …
Matched Iupac: … methyl (2S)-2-{2-fluoro-[1,1'-biphenyl]-4-yl}propanoate …
Methyl undecenoyl leucinate
Methyl undecenoyl leucinate is an active ingredient in whitening creams. It is an α-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression of various melanogenic genes.
Experimental
Matched Name: … Methyl undecenoyl leucinate …
Matched Iupac: … methyl (2S)-4-methyl-2-(undec-10-enamido)pentanoate …
Matched Description: … It is an α-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression ... Methyl undecenoyl leucinate is an active ingredient in whitening creams. …
Matched Categories: … Melanin Synthesis Inhibitor …
Matched Iupac: … methyl (2S)-4-methyl-2-(undec-10-enamido)pentanoate …
Matched Description: … It is an α-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression ... Methyl undecenoyl leucinate is an active ingredient in whitening creams. …
Matched Categories: … Melanin Synthesis Inhibitor …
Hesperidin methylchalcone
Experimental
Matched Synonyms: … Hesperidin methyl chalcone …
Matched Iupac: … -4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl …
Matched Iupac: … -4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl …
S-Methyl glutathione
Experimental
Matched Synonyms: … Glutathione S-methyl ester ... L-gamma-Glutamyl-S-methyl-L-cysteinylglycine …
Matched Name: … S-Methyl glutathione …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Name: … S-Methyl glutathione …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Methyl-D9-choline
Methyl-D9-choline is under investigation in clinical trial NCT01807910 (ER Stress in NAFLD).
Investigational
Matched Name: … Methyl-D9-choline …
Matched Description: … Methyl-D9-choline is under investigation in clinical trial NCT01807910 (ER Stress in NAFLD). …
Matched Description: … Methyl-D9-choline is under investigation in clinical trial NCT01807910 (ER Stress in NAFLD). …
Menadione
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Approved
Nutraceutical
Matched Synonyms: … 2-Methyl-1,4-naphthochinon ... 2-Methyl-1,4-Naphthalenedione ... 2-Methyl-1,4-naphthoquinone …
Matched Iupac: … 2-methyl-1,4-dihydronaphthalene-1,4-dione …
Matched Description: … A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted …
Matched Categories: … Blood and Blood Forming Organs ... Diet, Food, and Nutrition …
Matched Iupac: … 2-methyl-1,4-dihydronaphthalene-1,4-dione …
Matched Description: … A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted …
Matched Categories: … Blood and Blood Forming Organs ... Diet, Food, and Nutrition …
Depelestat
Investigational
Matched Synonyms: … Proteinase inhibitor m/nei (synthetic human) …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Pocapavir
Investigational
Matched Synonyms: … 1-((2-chloro-4-methoxyphenoxy)methyl)-4-((2,6-dichlorophenoxy)methyl)benzene ... 1-[(2-Chloro-4-methoxyphenoxy)methyl]-4-[(2,6-dichlorophenoxy) methyl]benzene …
Matched Iupac: … 2-chloro-1-({4-[(2,6-dichlorophenoxy)methyl]phenyl}methoxy)-4-methoxybenzene …
Matched Iupac: … 2-chloro-1-({4-[(2,6-dichlorophenoxy)methyl]phenyl}methoxy)-4-methoxybenzene …
Emodin
Emodin has been investigated for the treatment of Polycystic Kidney.
Investigational
Matched Synonyms: … 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione ... 1,3,8-trihydroxy-6-methyl-9,10-anthraquinone …
Matched Iupac: … 1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione …
Matched Iupac: … 1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione …
Tobacco leaf
Tobacco leaf allergenic extract is used in allergenic testing.
Approved
Matched Synonyms: … Tobacco oil …
Lazuvapagon
Lazuvapagon is under investigation in clinical trial NCT03116191 (Trial of SK-1404 for Nocturia Due to Nocturnal Polyuria in Japanese Subjects).
Investigational
Matched Synonyms: … (4s)-n-((2s)-1-hydroxypropan-2-yl)-methyl-1-(2-methyl-4-(3-methyl-1h-pyrazol-1-yl)benzoyl)-2,3,4,5-tetrahydro ... 1h-1-benzazepine-4-carboxamide, 2,3,4,5-tetrahydro-n-((1s)-2-hydroxy-1-methylethyl)-4-methyl-1-(2-methyl ... -4-(3-methyl-1h-pyrazol-1-yl)benzoyl)-, (4s)- …
Riociguat
Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurrent PH (pulmonary hypertension)...
Approved
Matched Synonyms: … Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate …
Matched Iupac: … methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate …
Matched Description: … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other ... regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for …
Matched Iupac: … methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate …
Matched Description: … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other ... regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for …
Methylisothiazolinone
Experimental
Matched Synonyms: … 2-Methyl-3-isothiazolone ... 2-Methyl-3(2H)-isothiazolone ... 2-Methyl-4-isothiazolin-3-one …
Matched Iupac: … 2-methyl-2,3-dihydro-1,2-thiazol-3-one …
Matched Iupac: … 2-methyl-2,3-dihydro-1,2-thiazol-3-one …
SB 224289
SB-224289 is a small molecule with a high affinity for human 5-HT1B receptors.
Investigational
Matched Synonyms: … (1'-methyl-6,7-dihydro-5h-spiro(furo(2,3-f)indole-3,4'-piperidin)-5-yl)(2'-methyl-4'-(5-methyl-1,2,4- ... (2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-yl)(1'-methyl-6,7-dihydrospiro(furo(2,3 ... 6,7-dihydro-1'-methyl-5-((2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1'-biphenyl-4-yl)carbonyl)spiro …
Matched Iupac: … 1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro …
Matched Iupac: … 1'-methyl-5-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carbonyl]-2,5,6,7-tetrahydrospiro …
Alosetron
Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer...
Approved
Withdrawn
Matched Synonyms: … 2,3,4,5-Tetrahydro-5-methyl-2-((5-methyl-1H-imidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one …
Matched Iupac: … 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-1-one …
Matched Description: … reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and ... Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Iupac: … 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-1-one …
Matched Description: … reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and ... Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal …
Matched Categories: … Alimentary Tract and Metabolism …
A-674563
Experimental
Matched Synonyms: … (alphaS)-alpha-(((5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl)oxy)methyl)benzeneethanamine …
Matched Iupac: … (2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}-3-phenylpropan-2-amine …
Matched Iupac: … (2S)-1-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}-3-phenylpropan-2-amine …
Displaying drugs 601 - 625 of 2055 in total