Displaying drugs 626 - 650 of 13940 in total
Guanidine
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is...
Approved
Matched Description: … It is also used in laboratory research as a protein denaturant. ... It is found in the urine as a normal product of protein metabolism. ... A strong organic base existing primarily as guanidium ions at physiological pH. …
Matched Categories: … MATE 2 Substrates …
Matched Categories: … MATE 2 Substrates …
Argatroban
Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Iupac: … methylpiperidine-2-carboxylic acid ... (2R,4R)-1-[(2S)-5-carbamimidamido-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl]-4- …
Matched Description: … Argatroban is a direct, selective thrombin inhibitor. ... Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT ... Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Matched Description: … Argatroban is a direct, selective thrombin inhibitor. ... Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT ... Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …
Dihydro-alpha-ergocryptine
Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine. Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product...
Approved
Matched Iupac: … (2R,4R,7R)-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo …
Matched Description: … These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. ... This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine …
Matched Description: … These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. ... This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine …
Tapinarof
Tapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment of adult psoriasis. It is available as a topical cream to be applied to the affected area once daily.[L41845, A248790] Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) produced in Photorhabdus luminescens, a gram-negative bacillus that...
Approved
Investigational
Matched Iupac: … 5-[(E)-2-phenylethenyl]-2-(propan-2-yl)benzene-1,3-diol …
Matched Description: … It is available as a topical cream to be applied to the affected area once daily. ... Tapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment ... [L41845, A248790] Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) …
Matched Description: … It is available as a topical cream to be applied to the affected area once daily. ... Tapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment ... [L41845, A248790] Tapiranof was first discovered as a metabolite (3,5-dihydroxy-4-isopropylstilbene) …
Avacincaptad pegol
Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule. It was developed to treat an advanced form of age-related macular degeneration (AMD) called geographic atrophy (GA). AMD is the leading cause of vision loss in developed countries for people over 50 years old, with...
Approved
Investigational
Matched Description: … This approval is based on the positive results obtained from 2 phase 3 clinical trials GATHER1 and GATHER2 ... Avacincaptad pegol is an RNA aptamer covalently bound to a branched polyethylene glycol (PEG) molecule ... ] AMD is the leading cause of vision loss in developed countries for people over 50 years old, with a …
Opium
Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was...
Approved
Illicit
Matched Description: … It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years ... During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. ... Therefore, opium is a sticky brown resin obtained by collecting and drying the latex that exudes from …
Acetylcarnitine
Acetylcarnitine is an investigational drug in the United states, Italy, United Kingdom, China, Israel, and Norway, and it is approved in Italy, Portugal, Argentina, Chile, Philippines, Australia, and India. Acetylcarnitine can be synthesized, but it is also naturally found in adequate amounts in healthy humans. In human plasma and tissues,...
Approved
Investigational
Octreotide
Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may also occur. Acromegaly is...
Approved
Investigational
Matched Description: … Acromegaly is a life-threatening disease requiring life-long management. ... Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues ... [L14501]
Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural …
Matched Salts cas: … 135467-16-2 …
Matched Salts cas: … 135467-16-2 …
Posaconazole
Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
Approved
Investigational
Vet approved
Matched Iupac: … difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-1-[(2S,3S)-2- …
Matched Description: … Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species …
Matched Description: … Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species …
Drospirenone
Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with Ethinyl estradiol. Most recently, it was approved by both Health Canada and the FDA in combination with Estetrol as an oral contraceptive therapy.[L33199,L33174] Aside from its contraceptive effects, drospirenone is used with estrogens to...
Approved
Matched Description: … Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination ... [A182543,A182552] In 2012, however, a safety statement by the FDA concluded that the increase in the ... Some studies have demonstrated a significantly increased risk and some demonstrating no risk of thromboembolic …
Matched Mixtures name: … Angeliq 1 mg/2 mg Filmtabletten ... ANGELIQ 1 MG/2 MG FILM KAPLI TABLET, 28 ADET …
Matched Mixtures name: … Angeliq 1 mg/2 mg Filmtabletten ... ANGELIQ 1 MG/2 MG FILM KAPLI TABLET, 28 ADET …
Ergosterol
A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Approved
Experimental
Matched Iupac: … ,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-ol ... (1R,3aR,7S,9aR,9bS,11aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-9a,11a-dimethyl-1H,2H,3H,3aH,6H,7H …
Matched Description: … A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably ... AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in …
Matched Description: … A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably ... AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in …
Influenza A virus A/California/7/2009(H1N1)-like hemagglutinin antigen (propiolactone inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/California/7/2009(H1N1)-like hemagglutinin antigen (propiolactone inactivated) …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Products: … Influenza A (H1N1) 2009 Monovalent Vaccine …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Products: … Influenza A (H1N1) 2009 Monovalent Vaccine …
Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (formaldehyde inactivated)
A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immunological defence...
Approved
Matched Name: … Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (formaldehyde inactivated) …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Matched Description: … A seasonally-specific component of the influenza vaccine. ... The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from ... Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed …
Levocabastine
Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.
Approved
Investigational
Matched Description: … Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis …
Aminocaproic acid
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
Approved
Investigational
Safinamide
Safinamide is for the treatment of parkinson's disease. It was approved in Europe in February 2015, and in the United States on March 21, 2017.
Approved
Investigational
Matched Iupac: … (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Disulfiram
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms...
Approved
Matched Description: … A carbamate derivative used as an alcohol deterrent. ... It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism …
Arbutamine
Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
Approved
Matched Iupac: … 4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol …
Matched Description: … Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Compounds used in a research, industrial, or household setting …
Matched Description: … Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Compounds used in a research, industrial, or household setting …
Valoctocogene roxaparvovec
Valoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active...
Approved
Investigational
Matched Description: … [L43282] The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes ... [L43292] Hemophilia A treatments such as prophylactic regimens of exogenous factor VIII or [emicizumab ... roxaparvovec was approved by EMA in September 2022 and is indicated for the treatment of severe hemophilia A. …
Sparsentan
Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETAR and 0.8 nM for AT1R).[A257330,L45300] Sparsentan is first in its class and orally active, and was created by...
Approved
Investigational
Matched Iupac: … )-[1,1'-biphenyl]-2-sulfonamide ... 4'-({2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl}methyl)-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl …
Matched Description: … Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin ... II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETA< ... In February 2023, the use of sparsentan to reduce proteinuria in adults with primary immunoglobulin A …
Matched Categories: … Angiotensin 2 Receptor Blocker ... Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA) …
Matched Description: … Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin ... II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETA< ... In February 2023, the use of sparsentan to reduce proteinuria in adults with primary immunoglobulin A …
Matched Categories: … Angiotensin 2 Receptor Blocker ... Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA) …
Flosequinan
Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due to increased mortality in chronic heart failure patients, found in drug trials.[A174979,L43942]
Approved
Withdrawn
Matched Description: … Flosequinan was approved in the USA and the UK for a year prior to being withdrawn from the market due …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Matched Categories: … Heterocyclic Compounds, 2-Ring …
Nortriptyline
Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.
Approved
Matched Synonyms: … 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine ... 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine …
Matched Iupac: … methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine …
Matched Description: … Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Iupac: … methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine …
Matched Description: … Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Ombitasvir
Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Iupac: … -1-oxobutan-2-yl]carbamate ... methyl N-[(2S)-1-[(2S)-2-({4-[(2S,5S)-1-(4-tert-butylphenyl)-5-{4-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino ... ]-3-methylbutanoyl]pyrrolidine-2-amido]phenyl}pyrrolidin-2-yl]phenyl}carbamoyl)pyrrolidin-1-yl]-3-methyl …
Matched Description: … Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 ... Ombitasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly [FDA …
Matched Description: … Ombitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 ... Ombitasvir is an inhibitor of NS5A, a protein essential for viral replication and virion assembly [FDA …
Phenylpropanolamine
Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Approved
Vet approved
Withdrawn
Matched Iupac: … 2-amino-1-phenylpropan-1-ol …
Matched Description: … Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist ... It has been used as a decongestant and appetite suppressant. …
Matched Mixtures name: … Oradrine 2 Tab …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Matched Description: … Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist ... It has been used as a decongestant and appetite suppressant. …
Matched Mixtures name: … Oradrine 2 Tab …
Matched Categories: … Adrenergic beta-2 Receptor Agonists ... Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Displaying drugs 626 - 650 of 13940 in total