Displaying drugs 751 - 775 of 1199 in total
Ammonium bicarbonate
Experimental
Matched Synonyms: … Carbonic acid, monoammonium salt …
Matched Categories: … Carbonic Acid ... Carbon Compounds, Inorganic …
Matched Categories: … Carbonic Acid ... Carbon Compounds, Inorganic …
Barecetamab
Investigational
Matched Synonyms: … Immunoglobulin g1, anti-(human epidermal growth factor receptor her3) (human monoclonal isu104 .gamma.1-chain), disulfide …
Spesolimab
Spesolimab is an interleukin-36 (IL-36) receptor antagonist. It is a humanized monoclonal immunoglobulin G1 antibody that was produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. The biosimilar of the drug, spesolimab-sbzo, was first approved by the FDA in September 2022 to treat generalized pustular psoriasis flares. Spesolimab...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human interleukin 36 receptor) (humanized monoclonal BI 655130 gamma1-chain), disulfide …
Matched Description: … works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and ... Committee for Medicinal Products for Human Use (CHMP) to be granted marketing authorization in October 2022 and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … works by inhibiting the inflammatory signaling pathway of IL-36,[L43090] which is often overexpressed and ... Committee for Medicinal Products for Human Use (CHMP) to be granted marketing authorization in October 2022 and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Rinucumab
Rinucumab is under investigation in clinical trial NCT02418754 (Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-related Macular Degeneration (AMD)).
Investigational
Matched Synonyms: … g4, anti-(human platelet-derived growth factor receptor~) (human monoclonal regn2176 heavy chain), disulfide …
Vebicorvir
Investigational
Matched Synonyms: … 1,4)thiazepine-8-carboxamide, 10,11-dihydro-11-oxo-n-((2-(trifluoromethyl)-5-thiazolyl)methyl)-, 5,5-dioxide …
Teprotumumab
Teprotumumab is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor. Following a clinical trial in which its efficacy in the treatment of thyroid eye disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016 and was approved by the FDA...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human monoclonal heavy chain), disulfide …
Matched Description: … disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and ... tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive ... Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Description: … disease (TED) was assessed, it received "breakthrough therapy" designation from the FDA in 2016[A190129] and ... tissue remodeling behind the eye, and previous treatment options typically involved multiple invasive ... Thyroid eye disease is a potentially debilitating complication of Graves' Disease involving inflammation and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Lutikizumab
Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy, and Pharmacodynamic Effects of ABT-981 in Patients With Knee Osteoarthritis).
Investigational
Matched Synonyms: … (synthetic human a-1234138 heavy chain), disulfide with synthetic human a-1234138 light chain, dimer …
Matched Description: … Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Lutikizumab is under investigation in clinical trial NCT02087904 (A Study Evaluating the Safety, Efficacy, and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Osemitamab
Investigational
Matched Synonyms: … IMMUNOGLOBULIN G1, ANTI-(HUMAN CLAUDIN 18.2) (HUMAN-MUS MUSCULUS MONOCLONAL TST001 .GAMMA.1-CHAIN), DISULFIDE …
Pulocimab
Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and Paclitaxel in Gastric or Gastroesophageal Junction Adenocarcinoma).
Investigational
Matched Synonyms: … anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ak109 .gamma.1-chain), disulfide …
Matched Description: … Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and …
Matched Description: … Pulocimab is under investigation in clinical trial NCT06341335 (A Study of Ak104/placebo Plus Ak109/placebo and …
Iron
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron...
Approved
Matched Synonyms: … Carbonyl iron ... Iron, carbonyl …
Matched Description: … A metallic element found in certain minerals, in nearly all soils, and in mineral waters. ... It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme ... Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms …
Matched Mixtures name: … Multi Vitamin, Iron and Fluoride ... Multi-Vitamin Fluoride and Iron Drops ... Children's Chewable Vit and Min Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition ... Blood and Blood Forming Organs ... multivitamins and iron ... iron and multivitamins …
Matched Description: … A metallic element found in certain minerals, in nearly all soils, and in mineral waters. ... It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme ... Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms …
Matched Mixtures name: … Multi Vitamin, Iron and Fluoride ... Multi-Vitamin Fluoride and Iron Drops ... Children's Chewable Vit and Min Tab …
Matched Categories: … Alimentary Tract and Metabolism ... Diet, Food, and Nutrition ... Blood and Blood Forming Organs ... multivitamins and iron ... iron and multivitamins …
Daprodustat
Daprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK.[A254167,A254162] Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular HIF1α and HIF2α and the induces...
Approved
Investigational
Matched Synonyms: … Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)- …
Matched Description: … HIF1α and HIF2α and the induces erythropoiesis. ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254157] On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Matched Description: … HIF1α and HIF2α and the induces erythropoiesis. ... As a potent inhibitor of PHD1, PHD2 and PHD3 (≥ 1000-fold selectivity), daprodustat stabilizes cellular ... [A254157] On October 2022, the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Zolbetuximab
Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in Combination With the EOX Regimen for CLDN18.2-positive Gastric Cancer).
Investigational
Matched Synonyms: … immunoglobulin G1, anti-(human Claudin-18.2) (human-mus musculus monoclonal IMAB362 heavy chain), disulfide …
Matched Description: … Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Zolbetuximab is under investigation in clinical trial NCT01630083 (Efficacy and Safety of IMAB362 in …
Matched Categories: … Amino Acids, Peptides, and Proteins …
gamma-carboxy-L-glutamic acid
Experimental
Matched Synonyms: … γ-carboxy-L-glutamic acid ... gamma-carboxy-glutamic acid …
Matched Name: … gamma-carboxy-L-glutamic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Name: … gamma-carboxy-L-glutamic acid …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Olsalazine
Olsalazine is an aminosalicylate and a prodrug of mesalamine (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of sulfapyridine. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inflammatory agent that works...
Approved
Matched Iupac: … 5-[(1E)-2-(3-carboxy-4-hydroxyphenyl)diazen-1-yl]-2-hydroxybenzoic acid …
Matched Description: … Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). ... , subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene ... [A257078] Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase …
Matched Salts name: … Olsalazine sodium …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … OLSALAZINA CARLO ERBA …
Matched Description: … Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). ... , subsequently reducing the production of pro-inflammatory factors like prostaglandin and leukotriene ... [A257078] Olsalazine is an anti-inflammatory agent that works by inhibiting cyclooxygenase and lipoxygenase …
Matched Salts name: … Olsalazine sodium …
Matched Categories: … Alimentary Tract and Metabolism …
Matched Products: … OLSALAZINA CARLO ERBA …
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Synonyms: … Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse …
Matched Description: … Food and Drug Administration. ... a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and ... complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human IgG1 heavy and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Description: … Food and Drug Administration. ... a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and ... complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human IgG1 heavy and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane
Experimental
Matched Name: … Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane …
Matched Iupac: … 5-({[2-({[(2-carboxy-2-methyl-1,3-dioxan-5-yl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)-2-methyl-1,3-dioxane …
Matched Iupac: … 5-({[2-({[(2-carboxy-2-methyl-1,3-dioxan-5-yl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)-2-methyl-1,3-dioxane …
Lecanemab
Lecanemab is a recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta (Aβ), which are implicated in the pathophysiology of Alzheimer’s disease. Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952] with high selectivity to Aβ...
Approved
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human beta-amyloid protofibril) (human-mus musculus monoclonal BAN2401 heavy chain), disulfide …
Matched Description: … recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and ... [L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and ... [L44537] Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain [A253947,A253952 …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Inolimomab
Inolimomab is under investigation as an agent to treat steroid-resistant graft vs host disease. It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.
Investigational
Matched Synonyms: … Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Mirvetuximab
Investigational
Matched Synonyms: … (human-mus musculus monoclonal m9346a heavy chain), disulfide with human-mus musculus monoclonal m9346a …
Potassium alum
Potassium alum is considered by the FDA as a generally recognized as safe (GRAS) substance. It is an inorganic salt, also called potassium aluminum sulfate with a formula of AlK(SO4)2 that is predominantly produced in the dodecahydrate form (AlK(SO4)2 * 12H2O). Potassium alum is formed by large, transparent crystals that...
Approved
Matched Synonyms: … Aluminum potassium disulfate ... Potassium aluminum disulfate …
Matched Iupac: … aluminium(3+) potassium disulfate …
Matched Mixtures name: … Gingibraid W Alum Pot Sulf and Epin 0e ... Gingibraid W Epineph and Alum 1e ... Gingibraid W Epineph and Alum 2e …
Matched Iupac: … aluminium(3+) potassium disulfate …
Matched Mixtures name: … Gingibraid W Alum Pot Sulf and Epin 0e ... Gingibraid W Epineph and Alum 1e ... Gingibraid W Epineph and Alum 2e …
Batoclimab
Batoclimab is under investigation in clinical trial NCT04428255 (A Clinical Study on the Efficacy and Safety of HBM9161 in Patients With ITP).
Investigational
Matched Synonyms: … g1(238-alanine, 239-alanine), anti-(human fcrn receptor) (human monoclonal hl161bkn .gamma.1-chain), disulfide …
Matched Description: … Batoclimab is under investigation in clinical trial NCT04428255 (A Clinical Study on the Efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Description: … Batoclimab is under investigation in clinical trial NCT04428255 (A Clinical Study on the Efficacy and …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Tafolecimab
Tafolecimab is under investigation in clinical trial NCT04031742 (A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial Hypercholesterolemia).
Investigational
Matched Synonyms: … anti-(human proprotein convertase subtilisin/kexin type 9) (human monoclonal ibi306 .gamma.2-chain), disulfide …
Matched Description: … Tafolecimab is under investigation in clinical trial NCT04031742 (A Study to Evaluate Safety and Efficacy …
Matched Description: … Tafolecimab is under investigation in clinical trial NCT04031742 (A Study to Evaluate Safety and Efficacy …
diethyl [(1R)-1,5-diaminopentyl]boronate
Experimental
Matched Name: … diethyl [(1R)-1,5-diaminopentyl]boronate …
Matched Iupac: … diethyl [(1R)-1,5-diaminopentyl]boronate …
Matched Iupac: … diethyl [(1R)-1,5-diaminopentyl]boronate …
Solnatide
Solnatide has been used in trials studying the treatment of Acute Lung Injury.
Investigational
Matched Synonyms: … Cys-gly-gln-arg-glu-thr-pro-glu-gly-ala-glu-ala-lys-pro-trp-tyr-cys cyclic (1->17)-disulfide ... L-cysteinylglycyl-L-glutaminyl-L-arginyl-L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-glutamylglycyl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-lysyl-L-prolyl-L-tryptophyl-L-tyrosyl-, cyclic (1->17)-disulfide …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 751 - 775 of 1199 in total