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Displaying drugs 8126 - 8150 of 11446 in total

Molnupiravir

Molnupiravir (EIDD-2801, MK-4482) is the isopropylester prodrug of N4-hydroxycytidine.[A193014,A193026] With improved oral bioavailability in non-human primates, it is hydrolyzed in vivo, and distributes into tissues where it becomes the active 5’-triphosphate form. The active drug incorporates into the genome of RNA viruses, leading to an accumulation of mutations known as...
Investigational
Matched Iupac: … [(2R,3S,4R,5R)-3,4-dihydroxy-5-[(4Z)-4-(hydroxyimino)-2-oxo-1,2,3,4-tetrahydropyrimidin-1-yl]oxolan-2 …
Matched Description: … non-human primates, it is hydrolyzed _in vivo_, and distributes into tissues where it becomes the active 5’ ... Molnupiravir was granted approval by the UK's Medicines and Health products Regulatory Agency (MHRA) on 4 …

Gold sodium thiosulfate

Experimental
Matched Iupac: … trisodium 1,5-dioxa-2lambda6,3,6lambda6,7-tetrathia-4-auraspiro[3.3]heptane-2,2,6,6-tetrone …

2,4-thiazolidinedione

Thiazolidinedione has been investigated for the treatment of Type 2 Diabetes, Diabetes Mellitus, and DIABETES MELLITUS, TYPE 2.
Investigational

3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile

Experimental
Matched Name: … 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile …
Matched Iupac: … 3-[6-bromo-2-fluoro-3-({1H-pyrazolo[3,4-c]pyridazin-3-yl}methyl)phenoxy]-5-chlorobenzonitrile …

Picrotoxin

A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem]
Experimental
Matched Iupac: … (1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.1^{ ... 9,12}.0^{3,5}.0^{5,13}]tetradecane-6,11-dione; (1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-(prop-1-en-2 …

O-Succinylbenzoate

Experimental

Meadowfoam seed oil

Meadowfoam seed oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental

3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID

Experimental

N(G)-Iminoethylornithine

Experimental
Matched Iupac: … (2S)-2-amino-5-ethanimidamidopentanoic acid …

Cyclic 3',5'-thymidine monophosphate

Experimental
Matched Synonyms: … 3',5'-Cyclic dTMP …
Matched Name: … Cyclic 3',5'-thymidine monophosphate …
Matched Iupac: … {[(2S,5R)-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy}phosphonic …

3'-O-Acetylthymidine-5'-diphosphate

Experimental
Matched Synonyms: … 3'-O-Acetylthymidine 5'-(trihydrogen diphosphate) …
Matched Name: … 3'-O-Acetylthymidine-5'-diphosphate …
Matched Iupac: … [({[(2R,3S,5R)-3-(acetyloxy)-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy …

GX-19 Vaccine

The GX-19 vaccine is a DNA vaccine created by Genexine, Inc. Company in Gyeonggi, Korea . As of June 2020, the vaccine candidate is undergoing Phase I and Phase IIa trials to determine dose levels for safety and efficacy[A219758,L16488].
Investigational
Matched Synonyms: … DNA vaccine expressing SARS-CoV-2 S-protein antigen …

Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells

Human olfactory mucosa-derived mesenchymal stem cells (OM-MSCs) reside in an accessible location of the nasal cavity and have properties of multipotency and high proliferation, which contributes to high potential for regenerative medicine. In humans, OM-MSCs are derived from the olfactory mucosa which is collected in vivo through rhinoscopy techniques and...
Investigational

Sulfamethoxypyridazine

Experimental
Matched Iupac: … 4-amino-N-(6-methoxypyridazin-3-yl)benzene-1-sulfonamide …

Chlorogenic Acid

Chlorogenic Acid has been used in trials studying the treatment of Advanced Cancer and Impaired Glucose Tolerance.
Investigational

Xipamide

Experimental
Matched Iupac: … 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide …

N-sulfoglucosamine sulfohydrolase recombinant

N-sulfoglucosamine sulfohydrolase recombinant is under investigation for the treatment of Mucopolysaccharidosis III and Sanfilippo Syndrome Type A (MPS IIIA).
Investigational

{[(2,2-Dihydroxy-Ethyl)-(2,3,4,5-Tetrahydroxy-6-Phosphonooxy-Hexyl)-Amino]-Methyl}-Phosphonic Acid

Experimental

Trenbolone

Trenbolone, also known as trienolone or trienbolone, is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as trenbolone acetate, trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group...
Vet approved

Schisandra chinensis fruit

Schisandra chinensis fruit is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Experimental

Artemisia annua leaf

Experimental

PF-06282999

Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects).
Investigational
Matched Iupac: … 2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-1-yl]acetamide …

Pavinetant

Pavinetant has been used in trials studying the basic science and treatment of Safety and Schizophrenia.
Investigational
Matched Iupac: … 3-methanesulfonamido-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide …

Nerinetide

Na 1 is under investigation in clinical trial NCT00728182 (Evaluating Neuroprotection in Aneurysm Coiling Therapy).
Investigational

Bekanamycin

Experimental
Matched Iupac: … (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2S,3R,4S,5S,6R)-4-amino …
Displaying drugs 8126 - 8150 of 11446 in total