Trenbolone
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Name
- Trenbolone
- Accession Number
- DB11551
- Description
Trenbolone, also known as trienolone or trienbolone, is a steroid used on livestock to increase muscle growth and appetite. To increase its effective half-life, trenbolone is administered as a prodrug as an ester conjugate such as trenbolone acetate, trenbolone enanthate, or trenbolone cyclohexylmethylcarbonate. Plasma lipases then cleave the ester group in the bloodstream leaving free trenbolone.
- Type
- Small Molecule
- Groups
- Vet approved
- Structure
Structure for Trenbolone (DB11551)
- Weight
- Average: 270.372
Monoisotopic: 270.161979948 - Chemical Formula
- C18H22O2
- Synonyms
- 17-b-Hydroxyestra-4,9,11-trien-3-one
- 17-beta-Hydroxyestra-4,9,11-trien-3-one
- 17-β-hydroxyestra-4,9,11-trien-3-one
- External IDs
- RU-2341
Pharmacology
- Indication
- Not Available
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
- Not Available
- Mechanism of action
- Not Available
- Absorption
- Not Available
- Volume of distribution
- Not Available
- Protein binding
- Not Available
- Metabolism
- Not Available
- Route of elimination
- Not Available
- Half-life
- Not Available
- Clearance
- Not Available
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
- Not Available
- Affected organisms
- Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Estrane steroids
- Direct Parent
- Estrogens and derivatives
- Alternative Parents
- 3-oxosteroids / 17-hydroxysteroids / Cyclohexenones / Secondary alcohols / Cyclic alcohols and derivatives / Organic oxides / Hydrocarbon derivatives
- Substituents
- 17-hydroxysteroid / 3-oxosteroid / Alcohol / Aliphatic homopolycyclic compound / Carbonyl group / Cyclic alcohol / Cyclic ketone / Cyclohexenone / Estrogen-skeleton / Hydrocarbon derivative
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- oxo steroid (CHEBI:35018) / Estrane and derivatives (C14261)
Chemical Identifiers
- UNII
- P53R4420TR
- CAS number
- 10161-33-8
- InChI Key
- MEHHPFQKXOUFFV-OWSLCNJRSA-N
- InChI
- InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1
- IUPAC Name
- (1S,3aS,3bS,11aS)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,11aH-cyclopenta[a]phenanthren-7-one
- SMILES
- [H][[email protected]@]12CC[[email protected]](O)[[email protected]@]1(C)C=CC1=C3CCC(=O)C=C3CC[[email protected]@]21[H]
References
- General References
- Marzin D: Ames test and trenbolone. Arch Toxicol. 1989;63(6):492-4. [PubMed:2695016]
- Spranger B, Metzler M: Disposition of 17 beta-trenbolone in humans. J Chromatogr. 1991 Apr 5;564(2):485-92. [PubMed:1874853]
- Pearson JT, Buttery PJ: Polyamine excretion by trenbolone acetate treated rats. Proc Nutr Soc. 1979 Sep;38(2):91A. [PubMed:504210]
- Richold M: The genotoxicity of trenbolone, a synthetic steroid. Arch Toxicol. 1988;61(4):249-58. [PubMed:3288174]
- Quinn MJ Jr, McKernan M, Lavoie ET, Ottinger MA: Immunotoxicity of trenbolone acetate in Japanese quail. J Toxicol Environ Health A. 2007 Jan;70(1):88-93. [PubMed:17162502]
- Gernhard K, Lange W: [A simple semiquantitative determination of trenbolone acetate and trenbolone in biological material from farm animals]. Arch Exp Veterinarmed. 1989 Nov;43(6):863-6. [PubMed:2619486]
- Furusawa N: A harmless method for determining trenbolone acetate together with 17beta-trenbolone in beef. J Chromatogr Sci. 2009 Mar;47(3):243-6. [PubMed:19298713]
- O'Keeffe M: Trenbolone levels in tissues of trenbolone acetate-implanted steers: radioimmunoassay determination using different antisera. Br Vet J. 1984 Nov-Dec;140(6):592-9. [PubMed:6509304]
- Quinn MJ Jr, Lavoie ET, Ottinger MA: Reproductive toxicity of trenbolone acetate in embryonically exposed Japanese quail. Chemosphere. 2007 Jan;66(7):1191-6. Epub 2006 Sep 20. [PubMed:16989888]
- Mizukami-Murata S, Kishi-Kadota K, Nishida T: 17beta-Trenbolone exposure programs metabolic dysfunction in larval medaka. Environ Toxicol. 2015 Jun 4. doi: 10.1002/tox.22158. [PubMed:26040664]
- External Links
- KEGG Drug
- D08627
- KEGG Compound
- C14261
- ChemSpider
- 23383
- 1484278
- ChEBI
- 35018
- ChEMBL
- CHEMBL3182355
- ZINC
- ZINC000003814429
- Wikipedia
- Trenbolone
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0586 mg/mL ALOGPS logP 2.47 ALOGPS logP 2.25 ChemAxon logS -3.7 ALOGPS pKa (Strongest Acidic) 18.4 ChemAxon pKa (Strongest Basic) -0.89 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 37.3 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 81.65 m3·mol-1 ChemAxon Polarizability 31.26 Å3 ChemAxon Number of Rings 4 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created on February 26, 2016 10:44 / Updated on June 12, 2020 10:53
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