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Displaying drugs 10401 - 10425 of 12422 in total
Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol. Melperone has been used for a span of greater than 30 years in the European Union . It has been well established in the treatment of confusion, anxiety, restlessness (particularly in...
Investigational
Matched Description: … Melperone has been used for a span of greater than 30 years in the European Union [L1316]. ... Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related ... Recently, it has been studied as a treatment of psychosis related to Parkinson's disease [L1316]. …
EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas. It is intended for the treatment of advanced cancer patients with solid tumors that are well vascularized. These tumors include the frequently occurring cancers of the lung,...
Investigational
Matched Description: … EPC2407 is a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of ... These tumors include the frequently occurring cancers of the lung, gastrointestinal tract, ovaries, ... It is intended for the treatment of advanced cancer patients with solid tumors that are well vascularized …
VSF-173 is an oral small molecule. It is an oral compound that has demonstrated effects on animal sleep/wake patterns and gene expression patterns suggestive of a stimulant effect. It is developed for the treatment of excessive sleepiness. Study shows that VSF-173 possesses a novel mechanism to address disorders of excessive...
Investigational
Matched Description: … It is developed for the treatment of excessive sleepiness. ... that has demonstrated effects on animal sleep/wake patterns and gene expression patterns suggestive of ... Study shows that VSF-173 possesses a novel mechanism to address disorders of excessive sleepiness. …
EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway.
Investigational
Matched Description: … EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway. …
ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).
Investigational
Matched Description: … ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 ... in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing). …
HTPEP-001 is a novel peptide that works to inhibit the activation of transforming growth factor beta (TGF-β). It is being investigated for the treatment of fibrosis.
Investigational
Matched Description: … It is being investigated for the treatment of fibrosis.[A263527] ... HTPEP-001 is a novel peptide that works to inhibit the activation of transforming growth factor beta …
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … leukemia in older patients and is being studied in the treatment of other types of cancer. ... subunit of cAMP dependent protein kinase. ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Investigational
RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy...
Investigational
Matched Description: … metabolism of the brain. ... RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of ... This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy …
MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … The presence of hAFP in the pregnant mother’s blood has long been associated with remission of many autoimmune ... MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and …
Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme oxalate decarboxylase. It is being investigated for the treatment of hyperoxaluria.
Investigational
Matched Description: … It is being investigated for the treatment of hyperoxaluria.[A258823] ... Reloxiliase is a first-in-class, oral crystalline formulation of the oxalate-specific, microbial enzyme …
DDP733 is an oral prokinetic drug which Dynogen is developing as a treatment for both Irritable Bowel Syndrome with constipation (IBS-c) and nocturnal gastroesophageal reflux disease (NGERD). It is a partial agonist of the serotonin type 3 receptor (5-HT3). Serotonin is a neurotransmitter that is known to be involved in...
Investigational
Matched Description: … the motility of the GI tract). ... It is a partial agonist of the serotonin type 3 receptor (5-HT3). ... Serotonin is a neurotransmitter that is known to be involved in the control of the gastrointestinal ( …
A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome...
Investigational
Matched Description: … AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP) ... , a pivotal inhibitor of apoptosis that is overexpressed in many tumors. ... This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs …
Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug. Tridihexethyl is no longer available in the US market.
Withdrawn
An ester of beclomethasone.
Experimental
Matched Description: … An ester of beclomethasone. …
Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. The fruits contain mixture of iridoids, flavonoids and compounds in leaves and flowers that structurally resemble sex hormones. Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of premenstrual stress syndrome (PMS) and cyclical breast...
Experimental
Matched Description: … Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of ... The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however ... Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. …
Ferric pyrophosphate is an iron replacement product. Free iron presents several side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate. It presents an increasing interest as this insoluble...
Experimental
Matched Description: … interactions of iron in plasma. ... side effects as it can catalyze free radical formation and lipid peroxidation as well as the presence of
Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in...
Investigational
VEGF-AS (Veglin) is an anti-angiogenesis non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of a variety of malignancies including mesothelioma. Veglin is one of several newly developed non-chemotherapy drugs being tested for possible utilization in the ongoing struggle to combat malignant mesothelioma.
Investigational
Matched Description: … a variety of malignancies including mesothelioma. ... Veglin is one of several newly developed non-chemotherapy drugs being tested for possible utilization ... non-chemotherapy drug (angiogenesis inhibitor) that was developed by VasGene Therapeutics, Inc. for the treatment of
ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058.
Investigational
Matched Description: … ASP4058 has been used in trials studying Food Effect of ASP4058 and Pharmacokinetics of ASP4058. …
Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Investigational
Matched Description: … primary afferent sensory neurons involved in nociception (the transmission of physiological pain). ... naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of
IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma).
Investigational
Matched Description: … IPI-549 is under investigation in clinical trial NCT03795610 (Window of Opportunity Study of IPI-549 …
R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of V-CAM1 to...
Investigational
Matched Description: … R411 is a non-steroid oral medicine for the treatment of asthma. ... It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory ... antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of
RTA 744 is a novel anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of primary and metastatic brain cancers. Anthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they are not used to treat brain cancers because current...
Investigational
Matched Description: … Anthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they ... anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of
One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
Experimental
Matched Description: … One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive …
Displaying drugs 10401 - 10425 of 12422 in total