Cyclomethicone 5

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Cyclomethicone 5
DrugBank Accession Number
DB11244
Background

Cyclomethicone 5 is member of cyclomethicone, which are a group of liquid methyl siloxanes that have low viscosity and high volatility. Cyclomethicones are cyclic in structure with a monomer backbone of one silicon and two oxygen atoms bonded together. Cyclomethicone 5 is used in cosmetic and personal products as a skin emollient.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 370.77
Monoisotopic: 370.093956741
Chemical Formula
C10H30O5Si5
Synonyms
  • Ciclopentasiloxane
  • Cyclomethicone D5
  • Cyclopentasiloxane
  • Decamethylcyclopentasiloxane
External IDs
  • KF 995
  • KF-995
  • SF 1202
  • VS 7158

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
3ce CR Eamy Water Proof Eye Liner 01 CatsLiquid0.16 g/0.6gTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 02 ZorroLiquid0.18 g/0.6gTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 08 Les MiserablesLiquid0.18 g/0.6gTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 13 CaffeineLiquid0.20 g/0.6gTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce Pink Im Good MascaraLiquid0.17 g/8.5gTopicalNanda Co., Ltd.2016-08-01Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
LiquidCyclomethicone 5 (25 mg/100mg) + Butane (30 mg/100mg) + Glycerin (25 mg/100mg)SprayCutaneousShantou Youjia E-Commerce Co.,Ltd.2024-02-012024-12-31US flag
Secret Key Tattoo Cover Cushion Spf50 Plus (21 Light Beige)Cyclomethicone 5 (8 g/100g) + Octinoxate (7 g/100g) + Phenyl trimethicone (3.5 g/100g) + Propylene glycol (5 g/100g) + Titanium dioxide (12 g/100g)LiquidTopicalZenpia2016-09-272018-12-19US flag
Secret Key Tattoo Cover Cushion Spf50 Plus (23 Natural Beige)Cyclomethicone 5 (8 g/100g) + Octinoxate (7 g/100g) + Phenyl trimethicone (3.5 g/100g) + Propylene glycol (5 g/100g) + Titanium dioxide (12 g/100g)LiquidTopicalZenpia2016-09-272018-12-19US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
3ce CR Eamy Water Proof Eye Liner 01 CatsCyclomethicone 5 (0.16 g/0.6g)LiquidTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 02 ZorroCyclomethicone 5 (0.18 g/0.6g)LiquidTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 08 Les MiserablesCyclomethicone 5 (0.18 g/0.6g)LiquidTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce CR Eamy Water Proof Eye Liner 13 CaffeineCyclomethicone 5 (0.20 g/0.6g)LiquidTopicalNanda Co., Ltd2016-08-102018-12-01US flag
3ce Pink Im Good MascaraCyclomethicone 5 (0.17 g/8.5g)LiquidTopicalNanda Co., Ltd.2016-08-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as organoheterosilanes. These are organosilicon compounds where the tetravalent silicon atom is linked to one or more heteroatoms.
Kingdom
Organic compounds
Super Class
Organometallic compounds
Class
Organometalloid compounds
Sub Class
Organosilicon compounds
Direct Parent
Organoheterosilanes
Alternative Parents
Organic metalloid salts / Organic oxygen compounds / Hydrocarbon derivatives
Substituents
Aliphatic heteromonocyclic compound / Hydrocarbon derivative / Organic metalloid salt / Organic oxygen compound / Organic salt / Organoheterosilane
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
0THT5PCI0R
CAS number
541-02-6
InChI Key
XMSXQFUHVRWGNA-UHFFFAOYSA-N
InChI
InChI=1S/C10H30O5Si5/c1-16(2)11-17(3,4)13-19(7,8)15-20(9,10)14-18(5,6)12-16/h1-10H3
IUPAC Name
decamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane
SMILES
C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1

References

General References
Not Available
PubChem Compound
10913
PubChem Substance
347827949
ChemSpider
10451
RxNav
1305744
ChEMBL
CHEMBL1885178
ZINC
ZINC000169743678

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LiquidTopical0.16 g/0.6g
LiquidTopical0.18 g/0.6g
LiquidTopical0.20 g/0.6g
LiquidTopical0.17 g/8.5g
CreamTopical3.6 g/30mL
CreamTopical0.35 mg/20mg
SprayCutaneous
LiquidTopical80.0 g/200mL
LiquidTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00803 mg/mLALOGPS
logP4.08ALOGPS
logP0.96Chemaxon
logS-4.7ALOGPS
pKa (Strongest Basic)-3.3Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area46.15 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity66.21 m3·mol-1Chemaxon
Polarizability35.09 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-0009000000-11c4a7c25d3952a47aa9
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0009000000-93c63336d67816d576a1
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-00di-0009000000-7284a3c30f86482c9ad2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0009000000-83b0f3a5570f82dabd91
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-000i-0009000000-3e04e8595a87defafb81
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0009000000-03c66e798486468f2c14
Predicted 1H NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M+H]+157.0689263
predicted
DarkChem Lite v0.1.0
[M+Na]+156.7213263
predicted
DarkChem Lite v0.1.0

Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53