Displaying drugs 10526 - 10550 of 12564 in total
Evofosfamide
TH-302 is a novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of solid tumor cancer cells. TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously used in cancer drugs such as ifosfamide, cyclophosphamide, and glufosfamide. TH-302 has been shown, in...
Investigational
Matched Description: … TH-302 is a nitroimidazole-linked prodrug of a brominated derivative of an isophosphoramide mustard previously ... novel cancer therapeutic specifically activated under the low oxygen or "hypoxic" conditions typical of …
SLV319
SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid type 1 (CB1) receptor. It is developed for the treatment of obesity and other metabolic disorders.
Investigational
Matched Description: … It is developed for the treatment of obesity and other metabolic disorders. ... SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid …
Octopamine
Octopamine is structurally similar to norepinephrine. It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World Anti-doping Agency (WADA) as of 2014.
Experimental
Matched Description: … Anti-doping Agency (WADA) as of 2014. ... It has been used as a nootropic, and therefore it and all of its enantiomer are prohibited by the World …
Zinpentraxin alfa
Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With Myelofibrosis).
Investigational
Matched Description: … Zinpentraxin alfa is a recombinant form of PTX-2, a naturally circulating human protein. ... It is under investigation in clinical trial NCT01981850 (A Phase 2 Study Of PRM-151 In Subjects With …
Rocapuldencel-T
Rocapuldencel-T is an autologous dendritic cell immunotherapy that was investigated in NCT02662634 (A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer).
Investigational
Matched Description: … AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer). ... autologous dendritic cell immunotherapy that was investigated in NCT02662634 (A Safety and Feasibility Study of …
RG2417
RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the mitochondria, the power plant of the human cell responsible for energy...
Investigational
Matched Description: … metabolism of the brain. ... RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of ... This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy …
MM-093
MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein normally produced at very high levels by the fetus and present in low levels in the blood of adults and children. Research on AFP suggests that it may play a role in modulating the immune system of...
Investigational
Matched Description: … The presence of hAFP in the pregnant mother’s blood has long been associated with remission of many autoimmune ... MM-093 is a recombinant version of human alpha-fetoprotein (hAFP), an immunomodulatory serum protein ... normally produced at very high levels by the fetus and present in low levels in the blood of adults and …
Becatecarin
Becatecarin is a derivative of rebeccamycin.
Investigational
Matched Description: … Becatecarin is a derivative of [rebeccamycin]. …
Desmethylsertraline
Desmethylsertraline is a metabolite of sertraline.
Experimental
Matched Description: … Desmethylsertraline is a metabolite of sertraline. …
Arachidonyltrifluoromethane
Specific inhibitor of phospholipase A2.
Investigational
Matched Description: … Specific inhibitor of phospholipase A2.[A252972] …
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … leukemia in older patients and is being studied in the treatment of other types of cancer. ... subunit of cAMP dependent protein kinase. ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
ABH001
ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).
Investigational
Matched Description: … ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 ... in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing). …
Propidium
Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits. [PubChem]
Experimental
Matched Description: … Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms ... of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes …
ALKS 27
ALKS 27 is an inhaled formulation of trospium chloride for the treatment of chronic obstructive pulmonary disease (COPD). Study showed that ALKS 27 was well-tolerated over a wide dose range, with no dose-limited effects observed.
Investigational
Matched Description: … ALKS 27 is an inhaled formulation of trospium chloride for the treatment of chronic obstructive pulmonary …
Recombinant Human Thrombopoietin
Recombinant human thrombopoietin is a full-length glycosylated cytokine produced by Chinese hamster ovary cells and is used to promote the generation of megakaryocytes and platelets.[A225691, A225696] This drug is used in the treatment of thrombocytopenia.
Investigational
Matched Description: … [A225691, A225696] This drug is used in the treatment of thrombocytopenia. ... glycosylated cytokine produced by Chinese hamster ovary cells and is used to promote the generation of …
Palucorcel
Palucorcel is an investigational stem cell therapy consisting of human umbilical tissue-derived cells. Developed by Janssen Biotech, it is being investigated for the treatment of various conditions such as amyotrophic lateral sclerosis (ALS) and macular degeneration.
Investigational
Matched Description: … Palucorcel is an investigational stem cell therapy consisting of human umbilical tissue-derived cells ... Developed by Janssen Biotech, it is being investigated for the treatment of various conditions such as …
AG-702
AG-702 is a recombinant human heat shock protein also known as stress protein. It is also known as HSPs, which are a group of proteins that are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. HSPs are present in all cells in...
Investigational
Matched Description: … I of clinical trial. ... types of environmental stresses like heat, cold and oxygen deprivation. ... It is also known as HSPs, which are a group of proteins that are induced when a cell undergoes various …
EA-2353
EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway.
Investigational
Matched Description: … EA-2353 is a small molecule inhibitor of kinase mediators of the Wnt pathway. …
Ad5-nCoV
Ad5-nCoV is a recombinant adenovirus type-5 vector (Ad5) vaccine currently being investigated for prophylaxis against SARS-CoV-2.[L12675,L12678] It is being developed by CanSino Biologics Inc., in partnership with the Beijing Institute of Biotechnology, who in March 2020 announced the approval of a phase I clinical trial (ChiCTR2000030906) with an expected completion...
Investigational
Matched Description: … of a phase I clinical trial (ChiCTR2000030906)[L12675] with an expected completion in December 2020. ... ., in partnership with the Beijing Institute of Biotechnology, who in March 2020 announced the approval ... The study will evaluate antibody response in healthy patients between the ages of 18 and 60 who will …
Vitex agnus-castus fruit extract
Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. The fruits contain mixture of iridoids, flavonoids and compounds in leaves and flowers that structurally resemble sex hormones. Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of premenstrual stress syndrome (PMS) and cyclical breast...
Experimental
Matched Description: … Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of ... The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however ... Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. …
Odronextamab
Odronextamab is a hinge-stabilized, fully human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of relapsed/refractory (R/R) B-Cell non-Hodgkin lymphoma (NHL).[A254187,A254197] Preliminary studies have shown that in patients with R/R NHL, the use of odronextamab does not lead to the development of neurologic toxicity; however, it can...
Investigational
Matched Description: … does not lead to the development of neurologic toxicity; however, it can lead to the development of ... cytokine release syndrome (CRS), a serious condition associated with the use of immunotherapy. ... human immunoglobulin G4 (IgG4)-based CD20×CD3 bispecific antibody currently evaluated for the treatment of …
KIN-3248
KIN-3248 is a small molecule that targets and inhibits oncogenic fibroblast growth factor receptors (FGFRs). It was designed to mainly target FGFR2 and FGFR3 alterations, which act as oncogenic drivers in 10-20% of cholangiocarcinoma and 20-35% of urothelial cancers, respectively. While effective, disease progression may occur 6 to 8 months...
Investigational
Matched Description: … Therefore, the broad inhibition of FGFR isoforms may be effective against different types of tumors. ... cholangiocarcinoma and 20-35% of urothelial cancers, respectively. ... was designed to mainly target FGFR2 and FGFR3 alterations, which act as oncogenic drivers in 10-20% of …
Buformin
Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.
Investigational
Withdrawn
Matched Description: … It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis. ... Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin …
Ficlatuzumab
Ficlatuzumab has been used in trials studying the treatment of Acute Myeloid Leukemia, Non-small Cell Lung Cancer, Mullerian Mixed Tumor of Ovary, Relapsed Acute Myeloid Leukemia, and Refractory Acute Myeloid Leukemia, among others.
Investigational
Matched Description: … Ficlatuzumab has been used in trials studying the treatment of Acute Myeloid Leukemia, Non-small Cell ... Lung Cancer, Mullerian Mixed Tumor of Ovary, Relapsed Acute Myeloid Leukemia, and Refractory Acute Myeloid …
Ultevursen
Ultevursen is a single-stranded RNA-based oligonucleotide targeting exon 13 of the USH2A gene that encodes usherin. It was developed by ProQR Therapeutics and is being investigated for the treatment of retinitis pigmentosa.
Investigational
Matched Description: … Ultevursen is a single-stranded RNA-based oligonucleotide targeting exon 13 of the USH2A gene that encodes ... It was developed by ProQR Therapeutics and is being investigated for the treatment of retinitis pigmentosa …
Displaying drugs 10526 - 10550 of 12564 in total