Displaying drugs 10601 - 10625 of 12589 in total
DNB-001
DNB-001 is a first-in-class oral therapy with dual mechanism of action, which is initially being developed for the treatment of glaucoma. In preclinical animal models, DNB-001 has demonstrated potent IOP- lowering effects as well as neuroprotective effects on the optic nerve.
Investigational
Matched Description: … for the treatment of glaucoma. ... DNB-001 is a first-in-class oral therapy with dual mechanism of action, which is initially being developed …
IC41
IC41 is a therapeutic peptide vaccine. It is being devloped by Intercell AG for the treatment of hepatitis C. The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell epitopes and the synthetic adjuvant poly-L-arginine.
Investigational
Matched Description: … It is being devloped by Intercell AG for the treatment of hepatitis C. ... The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell …
Ad-CEA vaccine
Ad-CEA vaccine is a cancer immunotherapy composed of carcinoembryonic antigen (CEA). Ad-CEA vaccine is under investigation in clinical trial NCT03050814 (Standard of Care Alone or in Combination With Ad-cea Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004).
Investigational
Matched Description: … Ad-CEA vaccine is a cancer immunotherapy composed of carcinoembryonic antigen (CEA). ... Ad-CEA vaccine is under investigation in clinical trial NCT03050814 (Standard of Care Alone or in Combination …
RGX-181
RGX-181 consists of an adeno-associated virus serotype 9 (AAV9) vector designed to deliver the soluble lysosomal enzyme tripeptidyl peptidase I (TPP1) gene. Developed by REGENXBIO, it is being investigated for the treatment of late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease.
Investigational
Matched Description: … RGX-181 consists of an adeno-associated virus serotype 9 (AAV9) vector designed to deliver the soluble ... Developed by REGENXBIO, it is being investigated for the treatment of late-infantile neuronal ceroid …
Elsubrutinib
Elsubrutinib is under investigation in clinical trial NCT04451772 (A Study of the Safety of Oral Elsubrutinib Capsules and Oral Upadacitinib Tablets Given Alone or in Combination (ABBV-599) for Adult Participants With Moderately to Severely Active Systemic Lupus Erythematosus to Assess Change in Disease State).
Investigational
Matched Description: … Elsubrutinib is under investigation in clinical trial NCT04451772 (A Study of the Safety of Oral Elsubrutinib …
Artefenomel
Artefenomel has been investigated for the treatment of Malaria.
Investigational
Matched Description: … Artefenomel has been investigated for the treatment of Malaria. …
Pyronaridine
Pyronaridine has been investigated for the treatment of Malaria.
Investigational
Matched Description: … Pyronaridine has been investigated for the treatment of Malaria. …
Enecadin
Enecadin has been investigated for the treatment of Stroke.
Investigational
Matched Description: … Enecadin has been investigated for the treatment of Stroke. …
SB-218078
SB-218078 is a specific inhibitor of CHK1.
Investigational
Matched Description: … SB-218078 is a specific inhibitor of CHK1.[A253117] …
TG4010
A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin 1 (MUC1) and interleukin-2 (IL-2) with potential immunostimulating and antineoplastic activities. Originally developed for the eradication of smallpox, MVA is a highly attenuated and replication-defective strain incapable of virion assembly and exerts potent immunostimulatory...
Investigational
Matched Description: … A bivalent cancer vaccine comprised of a modified vaccinia virus Ankara (MVA) strain encoding human mucin ... Expression of IL-2 augments the specific CTL response against MUC1 expressing cells. [L5191] ... strain incapable of virion assembly and exerts potent immunostimulatory activity against antigens. …
GEM-231
GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory subunit of cAMP dependent protein kinase. A monoclonal antibody combined with a toxic substance that is used treat certain types of acute myeloid leukemia in older patients and is being studied in the treatment of other types...
Investigational
Matched Description: … leukemia in older patients and is being studied in the treatment of other types of cancer. ... subunit of cAMP dependent protein kinase. ... GEM231 is a second-generation antisense oligonucleotide targeting the mRNA of the R1alpha regulatory …
Lemuteporfin
Lemuteporfin, under development by QLT Incorporated, is a benzoporphyrin-derived chlorin-like photosensitizer. It is intended for the treatment of beign prostatic hyperplasia.
Investigational
Matched Description: … It is intended for the treatment of beign prostatic hyperplasia. …
Vitex agnus-castus fruit extract
Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. The fruits contain mixture of iridoids, flavonoids and compounds in leaves and flowers that structurally resemble sex hormones. Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of premenstrual stress syndrome (PMS) and cyclical breast...
Experimental
Matched Description: … Clinical studies demonstrates effectiveness of vitex agnus-castus fruit extract in the management of ... The main mechanism of action of vitex agnus-castus fruit extract has not been fully elucidated, however ... Vitex agnus-castus fruit extract is obtained from dry fruits of Vitex agnus-castus. …
ABH001
ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).
Investigational
Matched Description: … ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 ... in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing). …
Serdemetan
Serdemetan has been used in trials studying the treatment of Neoplasms.
Investigational
Matched Description: … Serdemetan has been used in trials studying the treatment of Neoplasms. …
Ezutromid
Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne.
Investigational
Matched Description: … Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne. …
Phloroglucinol
Phloroglucinol has been used in trials studying the diagnostic of Colonoscopy.
Investigational
Matched Description: … Phloroglucinol has been used in trials studying the diagnostic of Colonoscopy. …
Sepranolone
Sepranolone has been investigated for the treatment of Premenstrual Dysphoric Disorder.
Investigational
Matched Description: … Sepranolone has been investigated for the treatment of Premenstrual Dysphoric Disorder. …
Apc001
Apc001 is an aptamer developed for the treatment of osteogenesis imperfecta.
Investigational
Matched Description: … Apc001 is an aptamer developed for the treatment of osteogenesis imperfecta. …
TBX-1400
TBX-1400 consists of human donor hematopoietic stem and progenitor cells.
Investigational
Matched Description: … TBX-1400 consists of human donor hematopoietic stem and progenitor cells. …
BCX10013
BCX10013 is a small molecule inhibitor of human complement factor D.
Investigational
Matched Description: … BCX10013 is a small molecule inhibitor of human complement factor D. …
HE3286
Investigational
Ibudilast
Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume shrinkage in patients with relapsing-remitting (RR) and/or secondary progressive (SP) multiple sclerosis (MS). Ibudilast is currently in development in the U.S. (codes: AV-411...
Investigational
Rolicyclidine
Rolicyclidine (PCPy) is classified as a dissociative anesthetic agent. It also has hallucinogenic and sedative properties. Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s.
Experimental
Illicit
Matched Description: … the Schedule I list of illegal drugs in the USA in the 1970s. ... Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to …
R1626
R1626 is one of a new class of hepatitis C therapies called polymerase inhibitors. It achieves significant reductions in viral load in chronic hepatitis C patients infected with the difficult to treat genotype 1 virus. R1626 is very effective in inhibiting viral replication
Investigational
Matched Description: … R1626 is one of a new class of hepatitis C therapies called polymerase inhibitors. …
Displaying drugs 10601 - 10625 of 12589 in total